Characterizing fentanyl outbreaks: Ethnographic and forensic perspectives

芬太尼爆发的特征：人种学和法医学的观点

• 批准号: 9296109
• 负责人: Raminta Daniulaityte
• 金额: $ 18.33万
• 依托单位: WRIGHT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-15 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9296109
• 关键词: Area; Autopsy; Cessation of life; Characteristics; Charge; Chemistry; Complement; Coroner; Country; County; Crime; Data; Disease Outbreaks; Drug abuse; Drug usage; Epidemic; Epidemiological trend; Ethnography; Fentanyl; Forensic Medicine; Gender; Geography; Harm Reduction; Health; Health Knowledge, Attitudes, Practice; Heroin; Intervention; Interview; Knowledge; Laboratories; Link; Methods; Morbidity - disease rate; Motivation; National Institute of Drug Abuse; Ohio; Opioid; Overdose; Pattern; Pharmaceutical Preparations; Pharmacologic Substance; Poisoning; Policies; Population; Price; Public Health; Recording of previous events; Reporting; Research; Research Personnel; Risk; Seizures; Specimen; Stream; Testing; Time; Time trend; Toxicology; Universities; analog; design; epidemiology study; experience; frontier; gender difference; innovation; interdisciplinary collaboration; mortality; opioid use; overdose death; public health intervention; response; trend

PROJECT SUMMARY Over the past few years, there has been a significant surge in non-pharmaceutical fentanyl (NPF) related unintentional overdose fatalities in multiple states across the U.S. Submitted in response to NIDA PAR- 16-055, Research Area 1 (Responses to sudden and severe emerging drug issues), this time-sensitive R21 application builds on interdisciplinary collaboration between researchers at the Center for Interventions, Treatment and Additions Research, the Department of Chemistry, Montgomery County Coroner's Office/Miami Valley Regional Crime Lab (MCCO/MVRCL) and Public Health-Dayton & Montgomery County. The overall purpose of the proposed study is to characterize NPF outbreaks through the integration of ethnographic/qualitative assessment of active user knowledge and experiences of NPF use, and the results from forensic analyses conducted by the postmortem toxicology and crime laboratories at MCCO/MVRCL. The study will be conducted in the Dayton Area (Montgomery County, Ohio), that has been recognized as a “new frontier” of the U.S. heroin epidemic, and the place of one of the largest NPF outbreaks in the country. The Specific Aims of the study are to: 1) Provide an in-depth understanding of active user knowledge and experiences related to the availability and use of NPF products. 2) Analyze forensic data to characterize toxicological features and epidemiological trends of NPF use. 3) Compare, contrast, and integrate ethnographic and forensic perspectives on NPF outbreaks. The proposed study is significant because it will provide new information about toxicological features of the outbreaks and user knowledge, attitudes and behaviors related to NPF use. The key innovation is the interdisciplinary collaboration to integrate ethnographic and forensic perspectives.

项目概要 过去几年，非药物芬太尼（NPF）的数量大幅增加 美国多个州发生相关意外服药过量死亡事件 响应 NIDA PAR- 提交 16-055，研究领域 1（应对突发和严重的新出现的药物问题），这个时间敏感的 R21 该应用程序建立在干预中心研究人员之间的跨学科合作的基础上， 治疗和添加研究，化学系，蒙哥马利县验尸官办公室/迈阿密 Valley 地区犯罪实验室 (MCCO/MVRCL) 和代顿和蒙哥马利县公共卫生部门。整体 拟议研究的目的是通过整合以下因素来描述 NPF 爆发的特征： 对积极用户的 NPF 使用知识和经验进行人种学/定性评估以及结果 来自 MCCO/MVRCL 尸检毒理学和犯罪实验室进行的法医分析。这 研究将在代顿地区（俄亥俄州蒙哥马利县）进行，该地区已被认为是 美国海洛因流行的“新前沿”，也是该国最大的 NPF 疫情爆发地之一。 研究的具体目标是： 1）深入了解活跃的用户知识和 与 NPF 产品的可用性和使用相关的经验。 2) 分析取证数据来表征 NPF 使用的毒理学特征和流行病学趋势。 3）比较、对比和整合 NPF 爆发的人种学和法医观点。拟议的研究意义重大，因为它将 提供有关爆发毒理学特征以及用户知识、态度和行为的新信息 与 NPF 使用相关的行为。关键的创新是跨学科合作以整合民族志 和法医的观点。