Characterizing fentanyl outbreaks: Ethnographic and forensic perspectives

项目摘要 在过去的几年里，非药物芬太尼（NPF）的数量大幅增加。 在美国多个州发生的相关意外过量死亡事件，提交给NIDA PAR- 16 - 055，研究领域1（应对突发和严重的新兴药物问题），这一时间敏感的R21 该应用程序建立在干预中心研究人员之间的跨学科合作基础上， 蒙哥马利县验尸官办公室/迈阿密化学系治疗和添加研究 山谷地区犯罪实验室（MCCO/MVRCL）和公共卫生代顿和蒙哥马利县。整体 拟议研究的目的是通过整合NPF爆发的特征， 对NPF使用的活跃用户知识和经验进行人种学/定性评估，以及结果 由MCCO/MVRCL的验尸毒理学和犯罪实验室进行的法医分析。的 研究将在代顿地区（俄亥俄州蒙哥马利县）进行，该地区已被公认为 美国海洛因流行的"新前沿"，以及该国最大的NPF爆发之一的地方。 研究的具体目标是：1）提供对主动用户知识的深入了解， 与NPF产品的可用性和使用有关的经验。2)分析取证数据， NPF使用的毒理学特征和流行病学趋势。3)比较、对比和整合 从人种学和法医学角度对NPF爆发进行分析。这项研究之所以重要，是因为它将 提供关于暴发的毒理学特征以及使用者知识、态度和 与NPF使用相关的行为。关键的创新是跨学科的合作，以整合民族志 和法医视角

PROJECT SUMMARY Over the past few years, there has been a significant surge in non-pharmaceutical fentanyl (NPF) related unintentional overdose fatalities in multiple states across the U.S. Submitted in response to NIDA PAR- 16-055, Research Area 1 (Responses to sudden and severe emerging drug issues), this time-sensitive R21 application builds on interdisciplinary collaboration between researchers at the Center for Interventions, Treatment and Additions Research, the Department of Chemistry, Montgomery County Coroner's Office/Miami Valley Regional Crime Lab (MCCO/MVRCL) and Public Health-Dayton & Montgomery County. The overall purpose of the proposed study is to characterize NPF outbreaks through the integration of ethnographic/qualitative assessment of active user knowledge and experiences of NPF use, and the results from forensic analyses conducted by the postmortem toxicology and crime laboratories at MCCO/MVRCL. The study will be conducted in the Dayton Area (Montgomery County, Ohio), that has been recognized as a “new frontier” of the U.S. heroin epidemic, and the place of one of the largest NPF outbreaks in the country. The Specific Aims of the study are to: 1) Provide an in-depth understanding of active user knowledge and experiences related to the availability and use of NPF products. 2) Analyze forensic data to characterize toxicological features and epidemiological trends of NPF use. 3) Compare, contrast, and integrate ethnographic and forensic perspectives on NPF outbreaks. The proposed study is significant because it will provide new information about toxicological features of the outbreaks and user knowledge, attitudes and behaviors related to NPF use. The key innovation is the interdisciplinary collaboration to integrate ethnographic and forensic perspectives.