Metabolic Core

代谢核心

• 批准号: 9173675
• 负责人: COLLEEN MARIE CRONIGER
• 金额: $ 10.3万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-25 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9173675
• 关键词: Acute; Blood Vessels; Catheterization; Catheters; Chronic; Chronic Disease; Client; Clinic; Communities; Comorbidity; Complications of Diabetes Mellitus; Consult; Data; Data Quality; Databases; Development; Diabetes Mellitus; Diet; Disease; Eating; Energy Metabolism; Ensure; Euglycemic Clamping; Exercise; Experimental Designs; Factor Analysis; Foundations; Functional disorder; Funding; Generations; Glucose Clamp; Glucose tolerance test; Hospitals; Image; Indirect Calorimetry; Insulin Resistance; Investigation; Islets of Langerhans; Knowledge; Liver diseases; Malignant Neoplasms; Measures; Medical Research; Medical center; Metabolic; Mission; Molecular; Mus; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pathogenesis; Phenotype; Procedures; Protocols documentation; Publishing; Quality Control; Research Design; Research Personnel; Resources; Rest; Services; Standardization; Techniques; Telemetry; Testing; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Virginia; Work; base; biological research; blood glucose regulation; embryonic stem cell; improved; in vivo; in vivo Model; insulin tolerance; investigator training; medical schools; member; metabolic phenotype; mouse model; non-alcoholic fatty liver; phenotypic data; research study; skills; tool; working group

ABSTRACT The mission of the MMPC consortium is to advance medical and biological research by providing the scientific community with standardized, high quality metabolic and phenotyping services for mouse models of diabetes, complications, obesity and related disorders. The Metabolic Core conducts in vivo and ex vivo metabolic experiments on mice for investigators within (Case Western Reserve University, Cleveland Clinic Foundation, MetroHealth Medical Center and Veterans Administration Hospital) and outside the Cleveland scientific community (Rutgers University, Emory University School of Medicine, Virginia Commonwealth University, and Temple University). The use of standardized protocols for in vivo models of obesity and diabetes is critical to understanding the molecular mechanisms for the pathogenesis of comorbidities associated with obesity, such as insulin resistance, type 2 diabetes, cancer and nonalcoholic fatty liver disease (NAFLD). The purpose of the Metabolic Core is to provide centralized facilities for the in vivo and ex vivo experiments to phenotype the investigator's specific mouse model. The Case-MMPC Metabolic Core has worked closely with the other NIH funded MMPC centers to standardize the experimental procedures for analyzing glucose homeostasis and indirect calorimetry. The interactions between the MMPC consortium is essential for designing studies that generate valid data that can be compared in the MMPC central data base and to improve the quality of data published.

摘要 MMPC联合体的使命是通过以下方式推进医学和生物学研究： 为科学界提供标准化、高质量的代谢和表型分析 糖尿病、并发症、肥胖症和相关疾病的小鼠模型服务。的 Metabolic Core为研究人员进行小鼠体内和离体代谢实验 在（凯斯西储大学，克利夫兰诊所基金会，MetroHealth医疗 中心和退伍军人管理医院）和克利夫兰科学界以外的 （罗格斯大学、埃默里大学医学院、弗吉尼亚联邦大学、 坦普尔大学（Temple University）使用标准化方案进行肥胖和肥胖症的体内模型， 糖尿病对于理解糖尿病发病机制的分子机制至关重要。 与肥胖相关的合并症，如胰岛素抵抗、2型糖尿病、癌症和 非酒精性脂肪肝（NAFLD）。代谢核心的目的是提供 用于体内和离体实验的集中设施， 特定小鼠模型。Case-MMPC代谢核心与其他NIH 资助MMPC中心，以标准化分析葡萄糖的实验程序 稳态和间接测热法。MMPC联盟之间的互动是 对于设计生成可在MMPC中进行比较的有效数据的研究至关重要 中央数据库，并提高公布数据的质量。