Modifying Young Adult Skin Cancer Risk and Protective Behaviors (UV4.me2): A Hybrid Type 2 Dissemination/Effectiveness Trial

改变年轻成人皮肤癌风险和保护行为 (UV4.me2)：2 型传播/有效性混合试验

• 批准号: 9237721
• 负责人: Carolyn Heckman
• 金额: $ 73.17万
• 依托单位: RESEARCH INST OF FOX CHASE CAN CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9237721
• 关键词: Address; Adolescent; Adoption; Adult; American Cancer Society; Assessment tool; Baseline Surveys; Behavior; Behavioral; Behavioral Model; Communities; Cost Analysis; Data; Diagnosis; Effectiveness; Effectiveness of Interventions; Eligibility Determination; Enrollment; Epidemic; Ethnic Origin; Evidence based intervention; Feedback; Funding; General Population; Goals; Hybrids; Incentives; Incidence; Individual; Institution; Internet; Intervention; Literature; Maintenance; Malignant Neoplasms; Nature; Nonprofit Organizations; Online Systems; Organ; Outcome; Pamphlets; Participant; Population; Preventive Intervention; Process; Public Health; Questionnaires; Race; Randomized; Randomized Controlled Trials; Recruitment Activity; Research; Research Personnel; Risk Assessment; Risk Behaviors; Risk Factors; Sampling; Self-Administered; Skin; Skin Cancer; Source; Sunburn; Surgeon; Tissues; UV Radiation Exposure; Ultraviolet Rays; Update; Work; age group; aged; base; behavior prediction; behavioral outcome; cancer risk; cost; cost effectiveness; demographics; effectiveness trial; efficacy study; efficacy trial; follow-up; high risk; improved; interactive multimedia; intervention effect; melanoma; multidisciplinary; news; novel; novel strategies; peer; programs; protective behavior; satisfaction; skin cancer prevention; social media; uptake; young adult

Abstract Skin cancer is a growing epidemic, with almost five million US diagnoses annually, in contrast with most cancers, which are decreasing in incidence. Although largely preventable, skin cancers can be deadly, debilitating, damaging, and disfiguring. US adolescents have the lowest skin protection rates of all age groups and also engage in increased ultraviolet radiation (UV) exposure as they move into adulthood. Thus, young adults are in need of intervention to reduce their skin cancer risk. Prior interventions to increase skin protection and/or decrease UV exposure among young adults have been limited in their dissemination and longitudinal assessment, and no prior interventions targeted to this population have been internet-based besides our own. Our research team developed a web-based intervention that was found to significantly decrease UV exposure and increase skin protection behaviors among young adults in a randomized controlled trial (RCT) of nearly 1000 participants recruited from a consumer research panel. The intervention (UV4.me) is individually-tailored, interactive, and multimedia in nature, and based on the Integrative Model of Behavioral Prediction. Similar to other online trials, 73% of eligible individuals completed the baseline questionnaire, 70% who were randomized to the intervention accessed it, and 68% accessed it and completed at least one module. However, we have an opportunity to increase the engagement, implementation, and ultimately, the impact of UV4.me. We will do this by adding several key interactive features/strategies suggested by participants, our data, and supported by the literature (i.e., by creating a mobile version, adding incentives embedded in the intervention, a behavior tracking and feedback feature, peer interaction component, and ongoing news updates). This Hybrid Type 2 dissemination-effectiveness project's purpose is to implement the enhanced UV4.me2 with adults aged 18-25 years at moderate to high risk of developing skin cancer and evaluate the intervention's effectiveness in a sample recruited online through national dissemination to the general population. This project will use the RE-AIM framework to determine the reach, effectiveness, implementation, maintenance, and cost of UV4.me2. The team will recruit individuals from several general online sources (e.g., nonprofits, social media, commercial). Our team has already recruited three non-profit organizations to promote uptake of UV4.me2 and a commercial skincare company to offer incentives to encourage participation of young adults from across the US. In order to evaluate intervention effectiveness, young adults who enroll in the study will be randomized to either receive the enhanced UV4.me2, the original UV4.me, or a skin cancer e-pamphlet from the American Cancer Society. In summary, this project proposes a novel approach to address an issue of growing public health significance. The uniquely well-suited multidisciplinary and multi-institution research team is comprised of junior, mid-level, and senior investigators who have previously worked together successfully on skin cancer prevention interventions.

摘要 皮肤癌是一种日益流行的疾病，与大多数癌症相比，美国每年有近500万人被诊断为皮肤癌。 它们的发病率正在下降。尽管皮肤癌在很大程度上是可以预防的，但它可能是致命的，使人虚弱， 破坏性的，毁容的。美国青少年的皮肤保护率是所有年龄段中最低的，而且 随着他们进入成年期，他们会接触到更多的紫外线(UV)。因此，年轻人在 需要干预以降低他们患皮肤癌的风险。事先采取干预措施加强皮肤保护和/或 年轻人中紫外线暴露的减少在传播和纵向上是有限的 除了我们自己的干预措施外，以前没有针对这一人群的干预措施是基于互联网的。 我们的研究团队开发了一种基于网络的干预措施，发现它可以显著减少紫外线暴露 并在一项近1000人的随机对照试验(RCT)中增加年轻人的皮肤保护行为 参与者是从消费者研究小组招募的。干预(UV4.me)是为个人量身定做的， 交互式、多媒体性质，并基于行为预测的综合模型。类似于 其他在线试验，73%的符合条件的个人完成了基线问卷，70%的人是随机的 对于干预，68%的人访问过它并至少完成了一个模块。然而，我们有一个 有机会增加UV4.Me的参与、实施和最终的影响。我们会这么做的 通过添加参与者建议的几个关键交互功能/策略，我们的数据并得到 文献(即，通过创建移动版本、在干预中嵌入激励措施、行为跟踪 以及反馈特征、对等交互组件和正在进行的新闻更新)。这款混合型2 传播实效项目的目的是在18-25岁的成年人中实施增强的UV4.me2 年患皮肤癌的中到高风险，并在样本中评估干预的效果 通过国家向普通民众传播在网上招募的人员。该项目将使用RE-AIM 确定UV4.me2覆盖范围、有效性、实施、维护和成本的框架。该队 将从几个一般的在线来源(例如，非营利组织、社交媒体、商业)招聘个人。我们队 已经招募了三个非营利性组织来推广UV4.me2和商业护肤品 该公司将提供激励措施，鼓励来自美国各地的年轻人参与。为了评估 干预的有效性，登记参加研究的年轻人将被随机分成两组，分别接受增强的 UV4.me2，最初的UV4.Me，或者美国癌症协会的皮肤癌电子小册子。总而言之， 该项目提出了一种新的方法来解决一个日益重要的公共卫生问题。独特的 由初级、中级和高级组成的多学科、多机构的研究团队 此前曾在皮肤癌预防干预方面成功合作的研究人员。