Modifying Young Adult Skin Cancer Risk and Protective Behaviors (UV4.me2):A Hybrid Type 2 Dissemination/Effectiveness Trial

改变年轻成人皮肤癌风险和保护行为 (UV4.me2)：2 型传播/有效性混合试验

• 批准号: 10050020
• 负责人: Carolyn Heckman
• 金额: $ 48.07万
• 依托单位: RBHS -CANCER INSTITUTE OF NEW JERSEY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10050020
• 关键词: Address; Adolescent; Adoption; Adult; American Cancer Society; Assessment tool; Baseline Surveys; Behavior; Behavioral; Behavioral Model; Cancer Prevention Intervention; Communities; Cost Analysis; Data; Diagnosis; Dissemination and Implementation; Effectiveness; Effectiveness of Interventions; Enrollment; Epidemic; Ethnic Origin; Evidence based intervention; Feedback; Funding; General Population; Goals; Hybrids; Incentives; Incidence; Individual; Institution; Internet; Intervention; Literature; Maintenance; Malignant Neoplasms; Nature; Nonprofit Organizations; Online Systems; Organ; Outcome; Pamphlets; Participant; Patient Recruitments; Population; Process; Public Health; Questionnaires; Race; Randomized; Randomized Controlled Trials; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Research; Research Personnel; Risk Assessment; Risk Behaviors; Risk Factors; Sampling; Self Administration; Skin; Skin Cancer; Source; Sunburn; Surgeon; Tissues; UV Radiation Exposure; Ultraviolet Rays; Update; Work; age group; aged; base; behavior prediction; behavioral outcome; cancer risk; cost; cost effectiveness; demographics; effectiveness trial; efficacy study; efficacy trial; follow-up; high risk; implementation intervention; implementation strategy; improved; interactive multimedia; intervention cost; intervention effect; melanoma; multidisciplinary; news; novel; novel strategies; online intervention; peer; programs; protective behavior; recruit; satisfaction; skin cancer prevention; social media; uptake; web-based intervention; young adult

Abstract Skin cancer is a growing epidemic, with almost five million US diagnoses annually, in contrast with most cancers, which are decreasing in incidence. Although largely preventable, skin cancers can be deadly, debilitating, damaging, and disfiguring. US adolescents have the lowest skin protection rates of all age groups and also engage in increased ultraviolet radiation (UV) exposure as they move into adulthood. Thus, young adults are in need of intervention to reduce their skin cancer risk. Prior interventions to increase skin protection and/or decrease UV exposure among young adults have been limited in their dissemination and longitudinal assessment, and no prior interventions targeted to this population have been internet-based besides our own. Our research team developed a web-based intervention that was found to significantly decrease UV exposure and increase skin protection behaviors among young adults in a randomized controlled trial (RCT) of nearly 1000 participants recruited from a consumer research panel. The intervention (UV4.me) is individually-tailored, interactive, and multimedia in nature, and based on the Integrative Model of Behavioral Prediction. Similar to other online trials, 73% of eligible individuals completed the baseline questionnaire, 70% who were randomized to the intervention accessed it, and 68% accessed it and completed at least one module. However, we have an opportunity to increase the engagement, implementation, and ultimately, the impact of UV4.me. We will do this by adding several key interactive features/strategies suggested by participants, our data, and supported by the literature (i.e., by creating a mobile version, adding incentives embedded in the intervention, a behavior tracking and feedback feature, peer interaction component, and ongoing news updates). This Hybrid Type 2 dissemination-effectiveness project's purpose is to implement the enhanced UV4.me2 with adults aged 18-25 years at moderate to high risk of developing skin cancer and evaluate the intervention's effectiveness in a sample recruited online through national dissemination to the general population. This project will use the RE-AIM framework to determine the reach, effectiveness, implementation, maintenance, and cost of UV4.me2. The team will recruit individuals from several general online sources (e.g., nonprofits, social media, commercial). Our team has already recruited three non-profit organizations to promote uptake of UV4.me2 and a commercial skincare company to offer incentives to encourage participation of young adults from across the US. In order to evaluate intervention effectiveness, young adults who enroll in the study will be randomized to either receive the enhanced UV4.me2, the original UV4.me, or a skin cancer e-pamphlet from the American Cancer Society. In summary, this project proposes a novel approach to address an issue of growing public health significance. The uniquely well-suited multidisciplinary and multi-institution research team is comprised of junior, mid-level, and senior investigators who have previously worked together successfully on skin cancer prevention interventions.

抽象的 皮肤癌是一种日益增长的流行病，与大多数癌症相比，每年近500万次诊断， 发病率正在降低。尽管在很大程度上可以预防，但皮肤癌可能会致命，使人衰弱， 有害和毁容。美国青少年在所有年龄段的皮肤保护率最低，也是 在成年后，会增加紫外线辐射（UV）的暴露。因此，年轻人在 需要干预以降低皮肤癌的风险。先前的干预措施，以增加皮肤保护和/或 年轻人的紫外线暴露减少受到限制的传播和纵向 评估，除了我们自己的外，没有针对该人群的事先干预措施是基于互联网的。 我们的研究团队开发了一种基于网络的干预措施，发现大大降低了紫外线的暴露 并在近1000个随机对照试验（RCT）中增加年轻人的皮肤保护行为 参与者是从消费者研究小组中招募的。干预（uv4.me）是单独限制的， 自然界中的交互式和多媒体，并基于行为预测的综合模型。类似于 其他在线试用 要访问干预措施，68％的人访问了它并完成了至少一个模块。但是，我们有一个 有机会增加参与，实施，并最终导致UV4.Me的影响我们会这样做 通过添加参与者建议的几个关键交互功能/策略，我们的数据，并由 文献（即，通过创建移动版本，添加了干预中嵌入的激励措施，行为跟踪 和反馈功能，同行交互组件和正在进行的新闻更新）。这个混合类型2 传播效应项目的目的是实施增强的UV4.ME2，成年人18-25岁 年度患皮肤癌的中度至高风险，并评估样品中干预的有效性 通过全国传播向普通人群在线招募。该项目将使用re-aim 确定UV4.ME2的覆盖范围，有效性，实施，维护和成本的框架。团队 将从几个一般在线资源（例如非营利组织，社交媒体，商业）中招募个人。我们的团队 已经招募了三个非营利组织来促进UV4.ME2的吸收和商业护肤品 公司提供激励措施，以鼓励来自美国各地的年轻人参加。为了评估 干预效果，参加研究的年轻人将被随机分配，以接受增强 UV4.Me2，原始的UV4.Me或美国癌症协会的皮肤癌E-Pamphlet。总之， 该项目提出了一种新的方法来解决公共卫生越来越重要的问题。独特的 合适的多学科和多机构研究团队由初中，中级和高级组成 以前曾成功合作过针对皮肤癌预防干预措施的研究人员。