Pregnancy and beyond: windows into disparities in women's cardiovascular health

怀孕及以后：了解女性心血管健康差异的窗口

• 批准号: 9096667
• 负责人: Claire E Margerison
• 金额: $ 13.22万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9096667
• 关键词: African American; Age; Area; Award; Behavior; Behavioral; Biological; Biology; Blood Pressure; Blood Vessels; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Chronic Disease; Data; Data Collection; Development; Education; Elderly; Epidemiology; Equation; Foundations; Functional disorder; Future; Goals; Health; Home environment; Hormones; Individual; Inflammatory; Intervention; Interview; K-Series Research Career Programs; Knowledge; Life; Life Cycle Stages; Lipids; Measurement; Measures; Mediation; Mental Depression; Mentors; Metabolic; Methods; Michigan; Mission; Modeling; National Heart, Lung, and Blood Institute; Occupations; Outcome; Pathway interactions; Perinatal Epidemiology; Pregnancy; Prevention; Psychosocial Factor; Psychosocial Influences; Public Health; Race; Reporting; Research; Research Activity; Research Training; Risk; Risk Factors; Sampling; Smoking; Social Network; Source; Surveys; Target Populations; Testing; Time; Training; Universities; Woman; Women' s Health; Work; cardiovascular disorder epidemiology; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; career; cohort; cost effective; demographics; experience; follow-up; health disparity; heart disease prevention; high school; innovation; insight; intimal medial thickening; middle age; mobile computing; perinatal health; physical inactivity; professor; programs; psychosocial; public health relevance; racial and ethnic; racial and ethnic disparities; social; social media; socioeconomic disparity; socioeconomics; tool

 DESCRIPTION (provided by applicant): Cardiovascular (CV) disease is the leading cause of death among women in the US and a major source of racial/ethnic and socioeconomic disparities in women's health. There is a fundamental gap in our understanding of which biological, behavioral, and psychosocial factors contribute most to disparities in women's CV health. In particular, despite growing evidence that pregnancy can serve as a window into women's later-life CV health; little work has taken advantage of this window to gain insight into race or SES disparities in CV health. The overall goal of this proposal is therefore to identify factors-from pregnancy and across the life-course-and that contribute to racial/ethnic and socioeconomic differences in women's later-life CV health. The proposed work will take advantage of the POUCHMoms study (2011-2014, n=678), a unique longitudinal cohort that includes detailed interview data and biologic samples from 3 key periods in the life- course-pre-pregnancy (assessed retrospectively at pregnancy), pregnancy, and mid-life (assessed once within 7-15 years post-pregnancy)-and is both racially and socioeconomically diverse. The first specific aim of the proposed work is to identify factors within the domains of biology, behavior, and psychosocial influences that can be measured at pregnancy or mid-life and that contribute to race and SES differences in women's CV health indicators (i.e., blood pressure, HTN and pre-HTN, risk scores, and intima-media thickness) at mid-life. Although important knowledge can be gained from the existing POUCHMoms data, continued, more frequent, and less burdensome follow-up of these women is essential to track development of CV risk over the life- course and to understand the temporal ordering of factors contributing to race and SES disparities. Therefore, the second specific aim is to develop and pilot test innovative methods for ongoing data collection in the POUCHMoms cohort using social media and mobile technology. The candidate, Dr. Claire Margerison-Zilko, is an Assistant Professor of Epidemiology at Michigan State University (MSU) and brings to the award strong training and research experience in social and perinatal epidemiology and health disparities research. The proposed NHLBI Mentored Career Development Award (K01) will provide Dr. Margerison-Zilko with additional training in 1) cardiovascular epidemiology and pathophysiology, especially as it relates to women's health during pregnancy; 2) life course approaches to chronic disease research; and 3) use of social media and mobile technologies in health research. The training and mentoring in these areas combined with the proposed research activities will enable Dr. Margerison-Zilko to achieve her long-term goal of building an independent and innovative research program examining racial/ethnic and socioeconomic disparities in women's cardiovascular (CV) health, with a focus on understanding relations between pregnancy and CV health.

 描述（由申请人提供）： 心血管（CV）疾病是美国女性死亡的主要原因，也是女性健康中种族/民族和社会经济差异的主要来源。我们对哪些生物、行为和心理社会因素对女性CV健康的差异贡献最大的理解存在根本性差距。特别是，尽管越来越多的证据表明怀孕可以作为女性晚年CV健康的窗口;很少有工作利用这一窗口来深入了解CV健康的种族或SES差异。因此，本提案的总体目标是确定从怀孕到整个生命过程的因素，以及导致女性晚年CV健康的种族/民族和社会经济差异的因素。拟议的工作将利用POUCHMoms研究（2011-2014，n=678），这是一个独特的纵向队列，包括生命过程中3个关键时期的详细访谈数据和生物样本-孕前（在怀孕时回顾性评估），怀孕和中年（在怀孕后7-15年内评估一次）-并且在种族和社会经济上都是多样化的。拟议工作的第一个具体目标是确定生物学，行为和心理社会影响领域内的因素，这些因素可以在怀孕或中年时测量，并有助于女性CV健康指标的种族和SES差异（即，血压、HTN和前HTN、风险评分和内膜中层厚度）。尽管可以从现有POUCHMoms数据中获得重要知识，但对这些女性进行持续、更频繁和负担更轻的随访对于跟踪整个生命过程中CV风险的发展以及了解导致种族和SES差异的因素的时间顺序至关重要。因此，第二个具体目标是开发和试点测试创新方法， 使用社交媒体和移动的技术在POUCHMoms队列中持续收集数据。候选人克莱尔·马吉里森-齐尔科博士是密歇根州立大学（MSU）流行病学助理教授，并为该奖项带来了在社会和围产期流行病学和健康差异研究方面的丰富培训和研究经验。拟议的NHLBI指导职业发展奖（K 01）将为Margerison-Zilko博士提供以下方面的额外培训：1）心血管流行病学和病理生理学，特别是与怀孕期间女性健康有关的方面; 2）慢性病研究的生命过程方法; 3）在健康研究中使用社交媒体和移动的技术。在这些领域的培训和指导与拟议的研究活动相结合，将使Margerison-Zilko博士能够实现她的长期目标，即建立一个独立和创新的研究计划，研究女性心血管（CV）健康的种族/民族和社会经济差异，重点是了解怀孕和CV健康之间的关系。