Conduct of studies to evaluate the toxic and carcinogenic potential of alpha-pinene in laboratory animals for the National Toxicology Program (NTP)

为国家毒理学计划 (NTP) 开展研究，评估 α-蒎烯对实验动物的毒性和致癌潜力

• 批准号: 9471286
• 负责人: BARNEY SPARROW
• 金额: $ 109.82万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2018-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9471286
• 关键词: Animals; Breathing; Chemicals; Chronic; Fertility; Flavoring; Goals; Human; Inhalation Exposure; Laboratory Animals; Mus; National Toxicology Program; Pathology Report; Phase; Rattus; Risk; Self Care; Sperm Count Procedure; Sperm Motility; Toxic effect; Toxicity Tests; Toxicokinetics; Turpentine; Writing; carcinogenicity; follow-up; hazard; male; reproductive

The goal of this project is to evaluate the chronic toxicity and carcinogenicity of alpha-pinene in rats and mice, following whole body inhalation exposure. Alpha-pinene is found in turpentine and in flavorings and fragrances. Humans may be exposed through use of personal care and cleaning products as well as in lumber processing and building activities. 2-Year chronic toxicity and carcinogenicity studies of alpha-pinene are the pathology/report writing phase. These studies include an assessment of fertility and sperm count and motility, as male reproductive effects are anticipated. Follow up mechanistic and toxicokinetic studies are approved. Keywords: toxicity, carcinogenicity, inhalation, alpha-pinene

本项目的目标是评价大鼠和小鼠全身吸入暴露后α-蒎烯的慢性毒性和致癌性。α-蒎烯存在于松节油、调味品和香水中。人类可能通过使用个人护理和清洁产品以及木材加工和建筑活动接触。2-年α-蒎烯的慢性毒性和致癌性研究是病理学/报告撰写阶段。这些研究包括对生育力、精子计数和活力的评估，因为预期会对男性生殖产生影响。批准后续机制和毒代动力学研究。 关键词：毒性，致癌性，吸入，α-蒎烯