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Conduct of studies to evaluate the toxic and carcinogenic potential of alpha-pinene in laboratory animals for the National Toxicology Program (NTP)

Conduct of studies to evaluate the toxic and carcinogenic potential of alpha-pinene in laboratory animals for the National Toxicology Program (NTP)
为国家毒理学计划 (NTP) 开展研究，评估 α-蒎烯对实验动物的毒性和致癌潜力
批准号：
9471286
负责人：
BARNEY SPARROW
金额：
$109.82万
依托单位：
BATTELLE MEMORIAL INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-04-15 至 2018-04-14
来源：
https://reporter.nih.gov/project-details/9471286
关键词：
AnimalsBreathingChemicalsChronicFertilityFlavoringGoalsHumanInhalation ExposureLaboratory AnimalsMusNational Toxicology ProgramPathology ReportPhaseRattusRiskSelf CareSperm Count ProcedureSperm MotilityToxic effectToxicity TestsToxicokineticsTurpentineWritingcarcinogenicityfollow-uphazardmalereproductive

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中文摘要
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英文摘要
The goal of this project is to evaluate the chronic toxicity and carcinogenicity of alpha-pinene in rats and mice, following whole body inhalation exposure. Alpha-pinene is found in turpentine and in flavorings and fragrances. Humans may be exposed through use of personal care and cleaning products as well as in lumber processing and building activities. 2-Year chronic toxicity and carcinogenicity studies of alpha-pinene are the pathology/report writing phase. These studies include an assessment of fertility and sperm count and motility, as male reproductive effects are anticipated. Follow up mechanistic and toxicokinetic studies are approved. Keywords: toxicity, carcinogenicity, inhalation, alpha-pinene
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