Developmental changes in reward responsivity: Associations with depression risk markers

奖励反应的发展变化：与抑郁风险标记的关联

• 批准号: 9232212
• 负责人: Thomas M Olino
• 金额: $ 72.81万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2021-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9232212
• 关键词: Address; Adolescence; Adolescent; Affect; Affective; Age; Attenuated; Behavior; Behavioral; Brain; Child; Child Rearing; Childhood; Chronology; Cognitive; Cross-Sectional Studies; Data; Depressed mood; Depressive disorder; Development; Developmental Process; Disease; Distal; Emotional; Etiology; Failure; Family; Family history of; Gender; General Population; Incidence; Individual; Intervention; Investigation; Joints; Link; Literature; Major Depressive Disorder; Measures; Mediating; Mental Depression; Methods; Modeling; National Institute of Mental Health; Nature; Neurobiology; Neurophysiology - biologic function; Parents; Participant; Pathway interactions; Patient Self-Report; Performance; Positive Valence; Prevention; Process; Psychopathology; Puberty; Public Health; Quality of life; Recording of previous events; Recruitment Activity; Reporting; Research; Research Domain Criteria; Rewards; Risk; Risk Factors; Risk Marker; Role; Socialization; Strategic Planning; Stress; System; Testing; Work; Youth; cohort; depression prevention; depressive symptoms; disability; early adolescence; endophenotype; expectation; high risk; insight; longitudinal analysis; longitudinal design; neuroimaging; novel; offspring; prevent; programs; rate of change; resilience; response; symptomatology; therapy development

Project Summary/Abstract: Major depressive disorder is a burdensome disease that is prevalent in the general population. Despite much research on risk for and etiology of depression, processes related to the development of depression are only beginning to be understood. Family history of depressive disorders and developmental status are well established risk factors for depressive disorders. Offspring of depressed parents are at increased risk for depression and depression rates increase in adolescence. However, these broad risks have been considered individually and as distal influences on the emergence of depression. More proximal processes require further investigation. Attenuated reward responsivity (RR) has been linked to the etiology of depression in studies using subjective report, objective behavioral, and neural functioning measures. Of particular importance, RR is related to risk factors for depression and is influenced by developmental processes. Specifically, never depressed offspring of depressed parents demonstrate attenuated responses to reward. Studies also find that reward responsiveness normatively increases across adolescence. Questions emerge concerning how family history of depression may influence the development of RR in adolescence and how these may influence the development of youth depressive symptoms. These longitudinal processes have not been comprehensively examined previously. This proposal will apply a true developmental psychopathology perspective in examining risk for depression. We hypothesize that offspring of depressed parents will demonstrate attenuated increases in reward function during adolescence and failure to demonstrate normative increases in reward function will be associated with emergent depressive symptoms. We will combine high-risk offspring and longitudinal developmental methods to address our aims. We will recruit 9-10 (n = 140) and 12-13 (n = 140) year old youth. Youth participants will be assessed on RR using self- and parent-reports, behavioral performance, and neuroimaging methods. Our expectation is that offspring of depressed parents will demonstrate attenuated increases in reward responsiveness and this developmental change will be associated with the emergence of depressive symptoms. This is the first research program to examine the interplay between family risk status for depression and development using a longitudinal design and including rigorous behavioral and neuroimaging components. The results of this work will have powerful implications for understanding the timing and nature of the development of RR in the transition to and through adolescence. Identification of periods of malleability will permit identification of when in development intervention efforts may target RR to prevent the development of depressive disorders. Our work will also identify specific mechanisms of attenuated reward responsivity development that will implicate prevention efforts, including individual cognitive and affective and/or parenting interventions and when these interventions may be most successful. This will lead to the reduction of the public health burden of depressive disorders.

项目摘要/摘要：重度抑郁症是一种在世界各地普遍存在的负担沉重的疾病 一般人口。尽管对抑郁症的风险和病因进行了大量研究，但与抑郁症相关的过程仍然存在。 抑郁症的发展才刚刚开始被理解。抑郁症家族史， 发育状况是抑郁症的公认危险因素。抑郁父母的后代 患抑郁症的风险增加，青春期抑郁症的发病率也会增加。然而，这些风险 已经被认为是个体的，并且是对抑郁症出现的远端影响。更近侧 进程需要进一步调查。衰减的奖励反应性（RR）与以下病因有关： 使用主观报告、客观行为和神经功能测量的研究中的抑郁症。的 特别重要的是，RR与抑郁症的危险因素有关，并受发育的影响。 流程.具体来说，抑郁父母的从不抑郁的后代表现出对 奖励研究还发现，奖励反应在整个青春期正常增加。问题 关于抑郁症家族史如何影响青春期RR的发展， 这些可能如何影响青少年抑郁症状的发展。这些纵向过程具有 以前没有全面检查过。该提案将适用于真正的发展 从精神病理学角度研究抑郁症的风险。我们假设抑郁症患者的后代 父母在青春期表现出奖励功能的减弱， 证明奖励功能的正常增加将与抑郁症状的出现有关。 我们将结合联合收割机高风险的后代和纵向发展的方法来实现我们的目标。我们将 招募9-10岁和12-13岁青年各140例。青年参与者将使用自我评估工具进行RR评估。 和父母报告，行为表现和神经成像方法。我们的期望是， 抑郁的父母会表现出奖励反应的减弱，这种发展 变化将与抑郁症状的出现有关。这是第一个研究项目， 采用纵向设计研究抑郁症的家庭风险状况与发展之间的相互作用 包括严格的行为和神经成像组件。这项工作的结果将具有强大的 对理解在向经常资源过渡和过渡期间发展经常资源的时机和性质的影响 青春期识别可塑性时期将有助于识别开发时间 干预措施可能以RR为目标，以防止抑郁症的发展。我们的工作也将 确定具体机制衰减奖励反应性发展，将牵连预防 努力，包括个人的认知和情感和/或育儿干预，当这些干预 可能是最成功的。这将导致减少抑郁症的公共卫生负担。