Transdisciplinary Training In Cardiovascular Research

描述(由申请者提供)：我们在马萨诸塞大学医学院(UMMS)提出了一个新的跨学科心血管科学培训计划，该计划将涵盖从基础科学到实施科学的全方位研究。我们将提供技能和经验，使我们的受训人员能够发现可以转化并应用于临床领域的新知识，以造福社会；并激发基于人类需求的基础研究。这项申请是心血管医学部(在医学部)和定量健康科学部之间的合作努力，将涉及多个UMMS校园范围的资源。传统上，研究培训一直是零散的，基础、临床和翻译工作往往是孤立进行的。目前在提高研究和卫生保健提供效率方面面临的挑战要求采用新的范式。在这种情况下，长椅科学家和非长椅科学家之间的合作导致“团队科学”日益成为应对这些挑战的必要手段。出于这个原因，我们目前的应用是跨学科的--这个术语描述了研究人员共同努力，超越基于学科的概念、理论和方法，作为解决共同研究主题的一种手段。因此，这项提议将通过先验地建立导师团队来打破各个学科之间的界限，从而为学员提供一个新颖的导师方案。拟议的T32计划的首要目标是为既是独立研究人员又是团队科学家的个人建立一个心血管培训基础设施。每个学员将有机会获得基础、临床/翻译、公共卫生和实施科学领域的专业知识，以及来自T0/T1和T2两端的导师，以提供关于研究成果的重要性和应用的独特视角。该计划将包括与非常成功的科学家合作、独立研究经验和新颖的学术计划。我们为临床医生-博士后实习生开设了临床调查理学硕士(MSCI)课程，并在生物医学科学研究生院为博士后实习生开设了多个博士课程。这种导师、科学学科和学术项目的广度为每个学员提供了个性化经验的灵活性，同时提供了强大的方法论基础。每名学员将确定一个主要的研究重点，与经验丰富的首席导师和团队密切合作，设计和完成一个研究项目，并提交结果供同行评审发表。与我们的跨学科方法一致，我们建议的计划还包括通过跨教职员工水平和学科视角的指导团队进行早期导师培训。我们计划的目标是：i)建立一个跨越基础、临床和人群健康学科的心血管研究培训计划，旨在将研究转化为有效的临床实践和政策，以及产生跨越整个心血管疾病(CVD)研究范围的新问题；ii)招募博士后和博士后实习生，从而在社会人口学特征、临床背景和学科视角方面产生多样化的实习生；iii)为实习生提供必要的个人指导、学术培训和技术技能，以确保他们作为独立研究人员和团队科学的贡献者取得成功；以及iv)在跨学科团队中提供“亲身实践”的研究经验，这种经验建立在目前密歇根大学管理学院各部门、中心和研究所之间的联系环境的优势之上。这项计划代表了部门间的共同努力。它将由密歇根大学医学院(DOM)心血管医学部主任小约翰·F·基尼医学博士和密歇根大学定量健康科学部(QHS)主任卡塔琳娜·基夫(Catarina Kiefe)博士共同指导。这两位联席董事分别是T0/T1和T2翻译研究的领导者。这一计划的成功实施将极大地改善密歇根大学的研究环境，并使我们的毕业生成为未来的研究人员。

DESCRIPTION (provided by applicant): We propose a new transdisciplinary cardiovascular sciences training program at the University of Massachusetts Medical School (UMMS) that will encompass the full spectrum of research from basic to implementation science. We will provide skills and experiences that position our trainees to uncover new knowledge that can be translated and implemented into the clinical arena for societal benefit; and inspire basic research based on human needs. This application is a collaborative effort between the Division of Cardiovascular Medicine (in the Department of Medicine) and the Department of Quantitative Health Sciences, and will involve multiple UMMS campus-wide resources. Traditionally, research training has been fragmented, with basic, clinical, and translational efforts often performed in isolation. Current challenges to improve efficiency in research and health care delivery mandate new paradigms. In this context, collaboration between bench and non-bench scientists has led to "team science" as an increasing necessity to meet these challenges. For this reason, our current application is transdisciplinary - a term describing investigators that work together to expand beyond discipline-based concepts, theories, and methods as a means to address a common research topic. Thus, this proposal will offer trainees a novel mentoring scheme by a priori establishing mentorship teams that break boundaries between individual disciplines. The overarching goal of the proposed T32 program is to build a cardiovascular training infrastructure for individuals who will be both independent investigators and team scientists. Each trainee will have the access to expertise from the basic, clinical/translational, public health, and implementation science arenas, and mentors from the T0/T1 and T2+ ends of the spectrum to provide a unique perspective on both the importance and the application of research results. This Program will include collaboration with highly successful scientists, independent research experiences, and novel academic programs. We have a Masters of Science in Clinical Investigation (MSCI) program for clinician-postdoctoral trainees and multiple PhD programs in the Graduate School of Biomedical Sciences for pre-doctoral trainees. This breadth of mentors, scientific disciplines, and academic programs offers the flexibility to individualize each trainee's experience while providing a strong methodological foundation. Each trainee will identify a major research focus, design and complete a research project in close collaboration with an experienced lead mentor and team, and will submit the results for peer-reviewed publication. Consistent with our transdisciplinary approach, our proposed program also includes early mentor training via mentoring teams across the continuum of faculty levels and disciplinary perspectives. The aims of our program are to: i) Establish a cardiovascular research training program across basic, clinical, and population health disciplines geared towards translating research into effective clinical practice and policy, as wel as generating new questions spanning the entire spectrum of cardiovascular disease (CVD) research; ii) Recruit pre-and post- doctoral trainees resulting in a diverse trainee pool with respect to sociodemographic characteristics, clinical background, and disciplinary perspective; iii) Provide trainees with the individual mentoring, academic training, and technical skills necessary to ensure their success as independent investigators as well as contributors to team science; and iv) Provide "hands on" research experience within transdisciplinary teams that builds on the strengths of the current environment of linkages between UMMS Departments, Centers, and Institutes. This program represents an interdepartmental joint effort. It will be co-directed by John F. Keaney, Jr., MD, Chief of Cardiovascular Medicine in the Department of Medicine (DOM) at UMMS and Catarina Kiefe, MD, PhD, Chair of the UMMS Department of Quantitative Health Sciences (QHS). These co- Directors are leaders in T0/T1 and T2+ translational research, respectively. The successful implementation of this program will greatly enhance the research environment at UMMS and position our graduates to the be researchers of tomorrow.