Transdisciplinary Training In Cardiovascular Research

描述（由申请人提供）：我们提议在马萨诸塞大学医学院（UMMS）开设一个新的跨学科心血管科学培训项目，该项目将涵盖从基础科学到实施科学的所有研究领域。我们将提供技能和经验，使我们的学员能够发现新的知识，这些知识可以转化并应用于临床领域，以造福社会；激发基于人类需求的基础研究。该应用程序是心血管医学系（医学系）和定量健康科学系之间的合作成果，将涉及UMMS校园范围内的多个资源。传统上，研究培训是分散的，基础、临床和转化工作往往是孤立进行的。当前提高研究和保健服务效率的挑战要求采用新的范例。在这种背景下，实验科学家和非实验科学家之间的合作已经导致“团队科学”成为应对这些挑战的日益必要的东西。出于这个原因，我们目前的应用是跨学科的——这个术语描述了研究人员共同努力，以超越基于学科的概念、理论和方法，作为解决共同研究课题的手段。因此，该建议将通过先验地建立导师团队来打破个体学科之间的界限，为受训者提供一种新颖的指导方案。T32项目的总体目标是为独立研究者和团队科学家建立心血管训练基础设施。每位学员都将有机会获得基础、临床/转化、公共卫生和实施科学领域的专业知识，以及来自T0/T1和T2+端的导师，就研究成果的重要性和应用提供独特的视角。该计划将包括与非常成功的科学家合作，独立研究经验和新颖的学术课程。我们有临床研究理学硕士（MSCI）项目，招收临床博士后和生物医学科学研究生院的博士研究生。导师、科学学科和学术项目的广度为每位学员提供了个性化体验的灵活性，同时提供了强大的方法论基础。每位学员将确定一个主要的研究重点，与经验丰富的导师和团队密切合作，设计和完成一个研究项目，并将结果提交给同行评审的出版物。与我们的跨学科方法相一致，我们提议的项目还包括通过指导团队跨教师水平和学科观点的早期导师培训。我们项目的目标是：i)建立一个横跨基础、临床和人口健康学科的心血管研究培训项目，旨在将研究成果转化为有效的临床实践和政策，并在心血管疾病（CVD）研究的整个领域产生新的问题；ii)招收pre-and - post- doctor实习生，从而在社会人口学特征、临床背景和学科观点方面形成多样化的实习生群体；iii)为受训者提供个人指导、学术培训和必要的技术技能，以确保他们成功地成为独立研究者和团队科学的贡献者；iv)在跨学科团队中提供“实践”研究经验，这些团队建立在UMMS部门，中心和研究所之间当前联系环境的优势之上。这个项目是跨部门的共同努力。它将由UMMS医学系心血管医学主任John F. Keaney, Jr.医学博士和UMMS定量健康科学系（QHS）主席Catarina Kiefe医学博士共同指导。这些联合主任分别是T0/T1和T2+翻译研究的领导者。该项目的成功实施将极大地改善UMMS的研究环境，并使我们的毕业生成为未来的研究人员。

DESCRIPTION (provided by applicant): We propose a new transdisciplinary cardiovascular sciences training program at the University of Massachusetts Medical School (UMMS) that will encompass the full spectrum of research from basic to implementation science. We will provide skills and experiences that position our trainees to uncover new knowledge that can be translated and implemented into the clinical arena for societal benefit; and inspire basic research based on human needs. This application is a collaborative effort between the Division of Cardiovascular Medicine (in the Department of Medicine) and the Department of Quantitative Health Sciences, and will involve multiple UMMS campus-wide resources. Traditionally, research training has been fragmented, with basic, clinical, and translational efforts often performed in isolation. Current challenges to improve efficiency in research and health care delivery mandate new paradigms. In this context, collaboration between bench and non-bench scientists has led to "team science" as an increasing necessity to meet these challenges. For this reason, our current application is transdisciplinary - a term describing investigators that work together to expand beyond discipline-based concepts, theories, and methods as a means to address a common research topic. Thus, this proposal will offer trainees a novel mentoring scheme by a priori establishing mentorship teams that break boundaries between individual disciplines. The overarching goal of the proposed T32 program is to build a cardiovascular training infrastructure for individuals who will be both independent investigators and team scientists. Each trainee will have the access to expertise from the basic, clinical/translational, public health, and implementation science arenas, and mentors from the T0/T1 and T2+ ends of the spectrum to provide a unique perspective on both the importance and the application of research results. This Program will include collaboration with highly successful scientists, independent research experiences, and novel academic programs. We have a Masters of Science in Clinical Investigation (MSCI) program for clinician-postdoctoral trainees and multiple PhD programs in the Graduate School of Biomedical Sciences for pre-doctoral trainees. This breadth of mentors, scientific disciplines, and academic programs offers the flexibility to individualize each trainee's experience while providing a strong methodological foundation. Each trainee will identify a major research focus, design and complete a research project in close collaboration with an experienced lead mentor and team, and will submit the results for peer-reviewed publication. Consistent with our transdisciplinary approach, our proposed program also includes early mentor training via mentoring teams across the continuum of faculty levels and disciplinary perspectives. The aims of our program are to: i) Establish a cardiovascular research training program across basic, clinical, and population health disciplines geared towards translating research into effective clinical practice and policy, as wel as generating new questions spanning the entire spectrum of cardiovascular disease (CVD) research; ii) Recruit pre-and post- doctoral trainees resulting in a diverse trainee pool with respect to sociodemographic characteristics, clinical background, and disciplinary perspective; iii) Provide trainees with the individual mentoring, academic training, and technical skills necessary to ensure their success as independent investigators as well as contributors to team science; and iv) Provide "hands on" research experience within transdisciplinary teams that builds on the strengths of the current environment of linkages between UMMS Departments, Centers, and Institutes. This program represents an interdepartmental joint effort. It will be co-directed by John F. Keaney, Jr., MD, Chief of Cardiovascular Medicine in the Department of Medicine (DOM) at UMMS and Catarina Kiefe, MD, PhD, Chair of the UMMS Department of Quantitative Health Sciences (QHS). These co- Directors are leaders in T0/T1 and T2+ translational research, respectively. The successful implementation of this program will greatly enhance the research environment at UMMS and position our graduates to the be researchers of tomorrow.