Transdisciplinary Training In Cardiovascular Research

描述（由申请人提供）：我们提议在马萨诸塞大学医学院 (UMMS) 开展一项新的跨学科心血管科学培训计划，该计划将涵盖从基础科学到实施科学的全方位研究。我们将提供技能和经验，使我们的学员能够发现新知识，这些知识可以转化并应用到临床领域以造福社会；并激发基于人类需求的基础研究。该应用程序是心血管医学科（医学系）和定量健康科学系之间的合作成果，并将涉及 UMMS 校园范围内的多个资源。传统上，研究培训是分散的，基础、临床和转化工作通常是孤立进行的。当前提高研究和医疗保健服务效率的挑战需要新的范式。在这种背景下，替补科学家和非替补科学家之间的合作导致“团队科学”成为应对这些挑战的日益必要性。因此，我们当前的应用程序是跨学科的——这个术语描述了研究人员共同努力超越基于学科的概念、理论和方法，作为解决共同研究主题的手段。因此，该提案将为学员提供一种新颖的指导方案，先行建立打破各个学科之间界限的指导团队。拟议的 T32 计划的总体目标是为既是独立研究人员又是团队科学家的个人建立心血管培训基础设施。每位学员都将获得来自基础、临床/转化、公共卫生和实施科学领域的专业知识，以及来自 T0/T1 和 T2 领域的导师，以就研究结果的重要性和应用提供独特的视角。该项目将包括与非常成功的科学家的合作、独立研究经验和新颖的学术项目。我们为临床医生博士后学员提供临床研究理学硕士 (MSCI) 课程，并在生物医学科学研究生院为博士前学员提供多个博士学位课程。导师、科学学科和学术项目的广泛性提供了灵活性，可以使每个学员的经验个性化，同时提供强大的方法论基础。每位学员将确定一个主要研究重点，与经验丰富的首席导师和团队密切合作，设计和完成一个研究项目，并将结果提交给同行评审出版物。与我们的跨学科方法一致，我们提出的计划还包括通过跨教师水平和学科观点的指导团队进行早期导师培训。我们计划的目标是： i) 建立涵盖基础、临床和人口健康学科的心血管研究培训计划，旨在将研究转化为有效的临床实践和政策，并提出涵盖整个心血管疾病 (CVD) 研究范围的新问题； ii) 招募博士前和博士后实习生，形成社会人口特征、临床背景和学科观点多样化的实习生库； iii) 为学员​​提供必要的个人指导、学术培训和技术技能，以确保他们作为独立研究者以及团队科学的贡献者取得成功； iv) 在跨学科团队中提供“实践”研究经验，这些经验建立在 UMMS 各系、中心和研究所之间当前联系环境的优势之上。该计划代表了跨部门的共同努力。该会议将由 UMMS 医学系 (DOM) 心血管医学科主任 John F. Keaney, Jr. 医学博士和 UMMS 定量健康科学 (QHS) 系主任 Catarina Kiefe 医学博士、哲学博士共同指导。这些联合主任分别是 T0/T1 和 T2 转化研究的领导者。该计划的成功实施将极大地改善 UMMS 的研究环境，并使我们的毕业生成为未来的研究人员。

DESCRIPTION (provided by applicant): We propose a new transdisciplinary cardiovascular sciences training program at the University of Massachusetts Medical School (UMMS) that will encompass the full spectrum of research from basic to implementation science. We will provide skills and experiences that position our trainees to uncover new knowledge that can be translated and implemented into the clinical arena for societal benefit; and inspire basic research based on human needs. This application is a collaborative effort between the Division of Cardiovascular Medicine (in the Department of Medicine) and the Department of Quantitative Health Sciences, and will involve multiple UMMS campus-wide resources. Traditionally, research training has been fragmented, with basic, clinical, and translational efforts often performed in isolation. Current challenges to improve efficiency in research and health care delivery mandate new paradigms. In this context, collaboration between bench and non-bench scientists has led to "team science" as an increasing necessity to meet these challenges. For this reason, our current application is transdisciplinary - a term describing investigators that work together to expand beyond discipline-based concepts, theories, and methods as a means to address a common research topic. Thus, this proposal will offer trainees a novel mentoring scheme by a priori establishing mentorship teams that break boundaries between individual disciplines. The overarching goal of the proposed T32 program is to build a cardiovascular training infrastructure for individuals who will be both independent investigators and team scientists. Each trainee will have the access to expertise from the basic, clinical/translational, public health, and implementation science arenas, and mentors from the T0/T1 and T2+ ends of the spectrum to provide a unique perspective on both the importance and the application of research results. This Program will include collaboration with highly successful scientists, independent research experiences, and novel academic programs. We have a Masters of Science in Clinical Investigation (MSCI) program for clinician-postdoctoral trainees and multiple PhD programs in the Graduate School of Biomedical Sciences for pre-doctoral trainees. This breadth of mentors, scientific disciplines, and academic programs offers the flexibility to individualize each trainee's experience while providing a strong methodological foundation. Each trainee will identify a major research focus, design and complete a research project in close collaboration with an experienced lead mentor and team, and will submit the results for peer-reviewed publication. Consistent with our transdisciplinary approach, our proposed program also includes early mentor training via mentoring teams across the continuum of faculty levels and disciplinary perspectives. The aims of our program are to: i) Establish a cardiovascular research training program across basic, clinical, and population health disciplines geared towards translating research into effective clinical practice and policy, as wel as generating new questions spanning the entire spectrum of cardiovascular disease (CVD) research; ii) Recruit pre-and post- doctoral trainees resulting in a diverse trainee pool with respect to sociodemographic characteristics, clinical background, and disciplinary perspective; iii) Provide trainees with the individual mentoring, academic training, and technical skills necessary to ensure their success as independent investigators as well as contributors to team science; and iv) Provide "hands on" research experience within transdisciplinary teams that builds on the strengths of the current environment of linkages between UMMS Departments, Centers, and Institutes. This program represents an interdepartmental joint effort. It will be co-directed by John F. Keaney, Jr., MD, Chief of Cardiovascular Medicine in the Department of Medicine (DOM) at UMMS and Catarina Kiefe, MD, PhD, Chair of the UMMS Department of Quantitative Health Sciences (QHS). These co- Directors are leaders in T0/T1 and T2+ translational research, respectively. The successful implementation of this program will greatly enhance the research environment at UMMS and position our graduates to the be researchers of tomorrow.