Multicenter AIDS Cohort Study - Part B (Baltimore Center)

多中心艾滋病队列研究 - B 部分（巴尔的摩中心）

• 批准号: 9468324
• 负责人: TODD T BROWN
• 金额: $ 388.68万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9468324
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Adherence; Adverse effects; Affect; Age; Aging; Aging-Related Process; Alcohol or Other Drugs use; Area; Baltimore; Chicago; Chronic Disease; Combination Medication; Communities; Complement; Coping Skills; Cytomegalovirus Infections; Data; Data Quality; District of Columbia; Energy Metabolism; Enrollment; Focus Groups; Fostering; Funding; Genetic; Goals; HIV; HIV Infections; HIV therapy; Host Defense; Immune System Diseases; Incidence; Infection; Inflammation; Investigation; Laboratories; Leadership; Liver Fibrosis; Liver diseases; Los Angeles; Malignant Neoplasms; Measurement; Mental Depression; Methodology; Methods; Monitor; Morbidity - disease rate; Names; National Institute of Allergy and Infectious Disease; Natural History; Outcome; Participant; Pathogenesis; Peripheral Blood Mononuclear Cell; Physiological; Plasma; Play; Psychosocial Factor; Quality of life; Questionnaires; Recording of previous events; Regimen; Regulatory T-Lymphocyte; Research; Research Personnel; Resistance; Risk Factors; Role; Site; Specimen; T-Lymphocyte Subsets; The Multicenter AIDS Cohort Study; Time Study; Viral load measurement; Washington; antiretroviral therapy; c new; cohort; elastography; experience; follow-up; frailty; immune activation; immunoregulation; improved; insight; men; men who have sex with men; public health relevance; recruit; repository; resilience; retention rate; working group

DESCRIPTION (provided by applicant): This application is for the renewal of the Study to Help the AIDS Research Effort (SHARE), which is the Baltimore-Washington DC site of the Multicenter AIDS Cohort Study (MACS). The MACS was funded by NIAID and NCI in 1983, with sites in Baltimore-Washington, Chicago, Pittsburgh, and Los Angeles to study the natural history of HIV infection in men who have sex with men. With the advent of effective combination antiretroviral therapy (cART), the MACS became also a study of the treated history of HIV infection, including the relationship between long-term controlled HIV infection and chronic diseases associated with aging. MACS participants, including 1808 enrolled in SHARE, have been followed semiannually since 1984 and have provided questionnaire data, physical exam data, laboratory data (including HIV serostatus, T cell subset measurements, and HIV viral load measurements), and a large repository of plasma, serum, cryopreserved peripheral blood mononuclear cells, and other specimens. Evaluating and following the prevalent and incident cases of HIV infection in SHARE and the MACS has provided key insights into risk factors for infection with HIV, monitoring and mechanisms of progression of HIV infection once it is established, host defense against HIV, genetic factors affecting HIV pathogenesis, and use, efficacy, and adverse effects of different types of therapy for HIV and related illnesses. SHARE and MACS are currently recruiting new participants who are receiving more recent cART regimens that are more potent, safer, and more convenient than older regimens, and which are initiated earlier in the course of HIV infection; this recruitment will be completed by the end of the current funding period in March, 2014. The specific aims of SHARE for the 2014-9 renewal period reflect those of the MACs and are to determine: the effect of evolving, earlier initiated c ART regimens on HIV-induced inflammation and immune dysfunction; the occurrence of and risk factors for emerging, non-AIDS-defining, high morbidity outcomes according to HIV infection and new c ART regimens; the determinants for incidence, progression and survival of malignancies, both AIDS- and non-AIDS-defining; the biologic and physiologic effects of treated HIV infection on the aging process; the relationships of substance use and psychosocial factors of aging in HIV infection with adherence, coping skills, resiliency, depression and quality of life and genetic factors associated with resistance to and control of HIV infection. SHARE will contribute to these goals through leadership of eight MACS working groups focusing on these topics, and through local studies focusing on liver disease, energy metabolism, cytomegalovirus infection, and regulation of immune activation and inflammation. These aims can be achieved only through continued follow-up of this extremely well-characterized cohort. SHARE and the MACS should continue to play a leading role in studies that will foster better treatments and prevention of HIV infection.

描述(由申请人提供)：此申请是为了更新研究，以帮助艾滋病研究努力(SHARE)，这是多中心艾滋病队列研究(MACS)的巴尔的摩-华盛顿特区站点。MACS于1983年由NIAID和NCI资助，在巴尔的摩-华盛顿、芝加哥、匹兹堡和洛杉矶设有地点，研究男男性行为者感染艾滋病毒的自然历史。随着有效的联合抗逆转录病毒疗法(CART)的出现，MACS也成为一项研究艾滋病毒感染的治疗史，包括长期受控的艾滋病毒感染与与老龄化相关的慢性疾病之间的关系。MACS参与者，包括参加SHARE的1808人，自1984年以来每半年被跟踪一次，并提供了问卷数据、体检数据、实验室数据(包括HIV血清、T细胞亚群测量和HIV病毒载量测量)，以及大量血浆、血清、冷冻保存的外周血单核细胞和其他标本。评估和跟踪SHARE和MACS的艾滋病毒感染流行和事件病例，为了解艾滋病毒感染的风险因素、艾滋病毒感染一旦建立起的监测和进展机制、宿主对艾滋病毒的防御、影响艾滋病毒发病的遗传因素以及不同类型的艾滋病毒和相关疾病治疗的使用、疗效和不良影响提供了重要的见解。Share和Mac目前正在招募接受较新CART方案的新参与者，这些方案比旧方案更有效、更安全、更方便，并且在艾滋病毒感染过程中更早启动；这一招募工作将在2014年3月当前资助期结束前完成。2014-2009年更新期间份额的具体目标反映了互委会的具体目标，并确定：较早启动的不断演变的抗逆转录病毒疗法对艾滋病毒引起的炎症和免疫功能障碍的影响；根据艾滋病毒感染和新的抗逆转录病毒疗法，新出现的、非艾滋病定义的、高发病率结果的发生和风险因素；恶性肿瘤的发病率、进展和生存的决定因素，包括艾滋病定义的和非艾滋病定义的；经治疗的艾滋病毒感染对衰老过程的生物和生理影响；HIV感染中物质使用和老龄化的心理社会因素与依从性、应对技能、复原力、抑郁和生活质量的关系以及与抵抗和控制HIV感染相关的遗传因素。Share将通过领导8个专注于这些主题的互委会工作组，以及通过侧重于肝病、能量代谢、巨细胞病毒感染以及免疫激活和炎症调节的本地研究，为实现这些目标做出贡献。只有通过对这一极具特点的群体继续采取后续行动，才能实现这些目标。SHARE和互委会应继续在促进更好地治疗和预防艾滋病毒感染的研究中发挥主导作用。

项目成果

Assessment of coronary artery calcium by chest CT compared with EKG-gated cardiac CT in the multicenter AIDS cohort study.

• DOI: 10.1371/journal.pone.0176557
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Chandra D;Gupta A;Leader JK;Fitzpatrick M;Kingsley LA;Kleerup E;Haberlen SA;Budoff MJ;Witt M;Post WS;Sciurba FC;Morris A
• 通讯作者: Morris A

Matrix metalloprotease-9 release from monocytes increases as a function of differentiation: implications for neuroinflammation and neurodegeneration.

单核细胞释放的基质金属蛋白酶 9 随着分化而增加：对神经炎症和神经变性的影响。

• DOI: 10.1016/s0165-5728(00)00308-8
• 发表时间: 2000
• 期刊: Journal of neuroimmunology
• 影响因子: 3.3
• 作者: Vos,CM;Gartner,S;Ransohoff,RM;McArthur,JC;Wahl,L;Sjulson,L;Hunter,E;Conant,K
• 通讯作者: Conant,K

Hepatitis A among homosexual men and injection drug users: more evidence for vaccination.

同性恋男性和注射吸毒者中的甲型肝炎：疫苗接种的更多证据。

• DOI: 10.1086/513757
• 发表时间: 1997
• 期刊: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
• 作者: Villano,SA;Nelson,KE;Vlahov,D;Purcell,RH;Saah,AJ;Thomas,DL
• 通讯作者: Thomas,DL

Prevalence of and risk factors for low bone mineral density in untreated HIV infection: a substudy of the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial.

• DOI: 10.1111/hiv.12242
• 发表时间: 2015-04
• 期刊: HIV medicine
• 影响因子: 3
• 作者: Carr A;Grund B;Neuhaus J;Schwartz A;Bernardino JI;White D;Badel-Faesen S;Avihingsanon A;Ensrud K;Hoy J;International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) START Study Group
• 通讯作者: International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) START Study Group

Free testosterone for hypogonadism assessment in HIV-infected men.

游离睾酮用于艾滋病毒感染男性性腺功能减退症的评估。

• DOI: 10.1093/cid/ciu129
• 发表时间: 2014
• 期刊: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
• 作者: Monroe,AnneK;Brown,ToddT
• 通讯作者: Brown,ToddT