TREAT (Time Restricted EATing) to improve cardiometabolic health

TREAT（限时进食）可改善心脏代谢健康

• 批准号: 10473751
• 负责人: BLANDINE B LAFERRERE
• 金额: $ 72.35万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10473751
• 关键词: Adherence; Adult; American; Award; Binding; Blood Glucose; Body Weight; Body Weight decreased; Caloric Restriction; Calories; Cardiovascular Diseases; Cause of Death; Chronic; Chronic Disease; Consumption; Controlled Study; Data; Diagnosis; Eating; Effectiveness; Elderly; Energy Intake; Energy Metabolism; Event; Fasting; Fatty acid glycerol esters; Glucose; Goals; Health; Health Benefit; Health Technology; High Prevalence; Hour; Human; Hyperphagia; Individual; Insulin Resistance; Intake; Intermittent fasting; Intervention; Life Style; Lipid Mobilization; Magnetic Resonance; Measures; Mediating; Mediator of activation protein; Metabolic; Metabolism; Methods; Modeling; Monitor; Mus; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Obesity; Overweight; Oxidative Stress; Participant; Pathway interactions; Patients; Pattern; Persons; Physical activity; Physiological; Pilot Projects; Prediabetes syndrome; Predisposition; Randomized; Randomized Controlled Trials; Self Efficacy; Sleep; Testing; Time-restricted feeding; actigraphy; aged; behavior change; cardiometabolic risk; cardiometabolism; cardiovascular disorder risk; cardiovascular risk factor; doubly-labeled water; efficacy study; efficacy testing; energy balance; follow-up; glucose metabolism; glucose monitor; high risk; improved; insight; insulin sensitivity; intervention effect; lifestyle intervention; mHealth; meetings; middle age; novel; oxidation; prevent; respiratory; smartphone Application; systemic inflammatory response; time use; weight maintenance

Project Summary/Abstract American adults have a high prevalence of overweight, obesity and prediabetes. Small weight loss delays the progression to type 2 diabetes and decrease cardiovascular risk, yet adherence to long-term calorie restriction is difficult to sustain. There is an urgency to find effective, easy-to-implement and sustain, and affordable life style interventions. Restricting the food intake interval, or time restricted eating (TRE) has been shown in small-scale pilot studies to result in weight loss and improve metabolism, while being less challenging than calorie count. We propose to rigorously assess the efficacy of TRE, administered via a smartphone application, on weight loss and decreased cardiovascular risk. To achieve this goal, metabolically unhealthy mid-life adults with overweight or obesity who habitually eat for more than 14h/day, will be randomized to a restricted eating window to 10h/d (TRE) or to their habitual eating window (≥ 14h, HABIT), and followed up to 12 months. Ambulatory measures of food intake, sleep, physical activity and glucose, and in-patient 24-h well-controlled studies will be done to determine the effect of TRE versus habitual eating duration (HABIT), as well as the mediators of these effects. Hypotheses: 1) TRE vs. HABIT will result in decreased fat mass, measured by quantitative magnetic resonance, and effect mediated via decreased daily total energy intake, measured by double labeled water; 2) TRE vs. HABIT will result in lower insulin resistance, lower glycemia and shift in fuel utilization preferentially to lipid mobilization; 2) Adherence to TRE (measured by usage of the app and reduction of the eating window), and self-efficacy will associate with the short-term effect (3 months) and the long-term sustainability (12 months) of TRE on fat mass loss. Results from this study will provide important insights into understanding the physiological and molecular interactions between restricting daily eating interval and metabolic function, and could provide evidence for using TRE interventions to improve metabolic health and decrease cardiovascular risk in the large number of mid-life and older Americans in great need of life style intervention.

项目概要/摘要 美国成年人超重、肥胖和糖尿病前期的患病率很高。轻微的体重减轻会延迟 进展为 2 型糖尿病并降低心血管风险，但坚持长期热量限制 很难维持。迫切需要找到有效、易于实施和维持且负担得起的生活 风格干预。限制食物摄入间隔或时间限制饮食（TRE）已在 小规模的试点研究可以减轻体重并改善新陈代谢，同时比其他研究更具挑战性 卡路里计数。我们建议严格评估通过智能手机应用程序管理的 TRE 的功效， 减肥和降低心血管风险。为了实现这一目标，代谢不健康的中年成年人 习惯性每天进食超过 14 小时的超重或肥胖者，将被随机分配到限制饮食组 窗口期为 10 小时/天 (TRE) 或习惯性饮食窗口期（≥ 14 小时，HABIT），并随访长达 12 个月。 动态测量食物摄入量、睡眠、体力活动和血糖，住院患者 24 小时控制良好 将进行研究以确定 TRE 与习惯性饮食持续时间 (HABIT) 的影响，以及 这些影响的中介者。假设：1) TRE 与习惯会导致脂肪量减少，测量方法为 定量磁共振，以及通过减少每日总能量摄入介导的影响，通过测量 双标水； 2) TRE 与习惯相比将导致较低的胰岛素抵抗、较低的血糖和燃料的转变 优先利用脂质； 2) 遵守 TRE（通过应用程序的使用情况和 进食窗口的减少），自我效能将与短期效果（3个月）和 TRE 对脂肪量减少的长期可持续性（12 个月）。这项研究的结果将提供重要的 深入了解限制每日饮食间隔之间的生理和分子相互作用 和代谢功能，并可为使用 TRE 干预措施改善代谢健康提供证据 并降低大量急需生活方式的中年和老年人的心血管风险 干涉。