TREAT (Time Restricted EATing) to improve cardiometabolic health

TREAT（限时进食）可改善心脏代谢健康

• 批准号: 10264828
• 负责人: BLANDINE B LAFERRERE
• 金额: $ 73.31万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264828
• 关键词: Adherence; Adult; American; Award; Binding; Blood Glucose; Body Weight; Body Weight decreased; Caloric Restriction; Calories; Cardiovascular Diseases; Cause of Death; Chronic; Chronic Disease; Consumption; Controlled Study; Data; Diagnosis; Eating; Effectiveness; Elderly; Energy Intake; Energy Metabolism; Event; Fasting; Fatty acid glycerol esters; Glucose; Goals; Health; Health Benefit; Health Technology; High Prevalence; Hour; Human; Hyperphagia; Individual; Insulin Resistance; Intake; Intermittent fasting; Intervention; Life Style; Lipid Mobilization; Magnetic Resonance; Measures; Mediating; Mediator of activation protein; Metabolic; Metabolism; Methods; Modeling; Monitor; Mus; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Obesity; Overweight; Oxidative Stress; Participant; Pathway interactions; Patients; Pattern; Physical activity; Physiological; Pilot Projects; Prediabetes syndrome; Predisposition; Randomized; Randomized Controlled Trials; Self Efficacy; Sleep; Testing; Time-restricted feeding; actigraphy; aged; behavior change; cardiometabolic risk; cardiometabolism; cardiovascular disorder risk; cardiovascular risk factor; doubly-labeled water; efficacy study; efficacy testing; energy balance; follow-up; glucose metabolism; glucose monitor; high risk; improved; insight; insulin sensitivity; intervention effect; lifestyle intervention; mHealth; meetings; middle age; novel; oxidation; prevent; respiratory; smartphone Application; systemic inflammatory response; time use; weight maintenance

Project Summary/Abstract American adults have a high prevalence of overweight, obesity and prediabetes. Small weight loss delays the progression to type 2 diabetes and decrease cardiovascular risk, yet adherence to long-term calorie restriction is difficult to sustain. There is an urgency to find effective, easy-to-implement and sustain, and affordable life style interventions. Restricting the food intake interval, or time restricted eating (TRE) has been shown in small-scale pilot studies to result in weight loss and improve metabolism, while being less challenging than calorie count. We propose to rigorously assess the efficacy of TRE, administered via a smartphone application, on weight loss and decreased cardiovascular risk. To achieve this goal, metabolically unhealthy mid-life adults with overweight or obesity who habitually eat for more than 14h/day, will be randomized to a restricted eating window to 10h/d (TRE) or to their habitual eating window (≥ 14h, HABIT), and followed up to 12 months. Ambulatory measures of food intake, sleep, physical activity and glucose, and in-patient 24-h well-controlled studies will be done to determine the effect of TRE versus habitual eating duration (HABIT), as well as the mediators of these effects. Hypotheses: 1) TRE vs. HABIT will result in decreased fat mass, measured by quantitative magnetic resonance, and effect mediated via decreased daily total energy intake, measured by double labeled water; 2) TRE vs. HABIT will result in lower insulin resistance, lower glycemia and shift in fuel utilization preferentially to lipid mobilization; 2) Adherence to TRE (measured by usage of the app and reduction of the eating window), and self-efficacy will associate with the short-term effect (3 months) and the long-term sustainability (12 months) of TRE on fat mass loss. Results from this study will provide important insights into understanding the physiological and molecular interactions between restricting daily eating interval and metabolic function, and could provide evidence for using TRE interventions to improve metabolic health and decrease cardiovascular risk in the large number of mid-life and older Americans in great need of life style intervention.

项目摘要/摘要 美国成年人的超重，肥胖和糖尿病前期的患病率很高。减肥延迟 发展为2型糖尿病并降低心血管风险，但坚持长期卡路里限制 很难维持。有一个迫切需要找到有效，易于实施和维持和负担得起的生活 样式干预措施。限制食物摄入间隔或限制时间饮食（TRE）已显示 小规模的试点研究可导致体重减轻并改善新陈代谢，而挑战者比 卡路里计数。我们建议严格评估通过智能手机应用程序管理TRE的效率， 体重减轻和改善心血管风险。为了实现这一目标，代谢不健康的中年成年人 安全食用超过14h/天的超重或肥胖症将随机分配给有限的饮食 窗口到10h/d（TRE）或习惯饮食窗口（≥14h，习惯），然后随访长达12个月。 食物摄入量，睡眠，体育锻炼和葡萄糖的卧床措施以及患者24小时控制 将进行研究以确定TRE与习惯饮食持续时间（习惯）的影响以及 这些影响的介体。假设：1）TRE与习惯将导致脂肪质量减少，以 定量磁共振和通过减少的每日总能量摄入介导的效果，以 双标记的水； 2）TRE与习惯会导致胰岛素抵抗，较低的血糖和燃料转移 优先利用脂质动员； 2）遵守TRE（通过使用应用程序来衡量 减少饮食窗口），自我效应将与短期效应（3个月）和 长期可持续性（12个月）的脂肪质量损失。这项研究的结果将提供重要的 了解了解日常饮食间隔之间的身体和分子相互作用 和代谢功能，并且可以提供使用TRE干预措施改善代谢健康的证据 并降低大量中年和年龄较大的美国人的心血管风险 干涉。