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Molecular Basis of Immunity

Molecular Basis of Immunity
免疫的分子基础
批准号:
10383664
负责人:
MADELEINE W. CUNNINGHAM
金额:
$22.97万
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-06-01 至 2023-05-31
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Abstract The immunologist of tomorrow must appreciate both basic and clinical immunology to effectively utilize modern tools of research in the pursuit of new knowledge about immune mediated and infectious diseases and their pathogenesis as well as for development of new vaccines and therapies against immune-mediated diseases. Training the scientist and the physician-scientist in immunology and its relationship to infectious diseases as well as to other related disciplines such as pathology, biochemistry, cell biology, and biotechnology will be crucial for the future of immunological sciences. To facilitate the distribution of knowledge in the field of immunology, the Immunology Training Program goals are to provide fundamental and research training to 4 predoctoral and 1 postdoctoral fellows with an immunology faculty of 25 preceptors including 7 new faculty. The program is unique in that it encompasses faculty from the University of Oklahoma Health Sciences Center (OUHSC) and the Oklahoma Medical Research Foundation (OMRF) as well as its strong focus on microbial as well as host immunology. The participating training faculty are particularly strong in the 4 disciplines emphasized in the Immunology Training Program, which include 1) Responses to Pathogens, 2) Lymphocyte Development and Signaling, 3) Inflammation and 4) Autoimmunity. The faculty preceptors have interacted on the OUHSC campus for years, forming a network that is particularly suited to train a cohesive group of pre and postdoctoral fellows in molecular immunology. The program recruits students and fellows from national and international sources, has strong NIH funded research programs, and has new faculty and facilities all of which foster an atmosphere of excellence in training. The predoctoral students are eligible for the training program after completion of their lab rotations and qualifying exam. The Immunology Training Program will provide in-depth enrichment in the 4 sub-disciplines to the pre and postdoctoral trainees. Postdoctoral fellows are strongly encouraged to take coursework and to mentor predoctoral students to enhance their immunology experience. The Immunology Training Program advisory and selection committee selects the pre and postdoctoral trainees and act in an advisory capacity. Since the beginning of the program, September 1, 2001, the objectives of the program are being met to provide excellence in research, and immunology course work as well as retreats and the Immunology Journal Club class which has been important for teaching current state of the art immunology to the trainees and faculty. Yearly retreats and the journal club class have been effective in bringing pre and postdoctoral fellows together with the immunology training faculty in an environment that fosters excellence. Our program has been and will continue to be important to prepare trainees for future careers in immunology.
期刊论文(135)
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会议论文
Toll-like receptor 7 (TLR7) modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells.
Toll 样受体 7 (TLR7) 调节暴露于同基因晚期凋亡细胞的小鼠的抗核小体自身抗体同种型和肾补体沉积。
DOI: 10.1136/ard.2009.108282
发表时间: 2010
期刊: Annals of the rheumatic diseases
影响因子: 27.4
作者: [Pan,Zi-jian, Maier,Shannon, Schwarz,Karen, Azbill,Jennifer, Akira,Shizuo, Uematsu,Satoshi, Farris,ADarise]
通讯作者: Farris,ADarise
DOI: 10.4049/jimmunol.0800861
发表时间: 2009-07-01
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者: [Zhang P, Cox CJ, Alvarez KM, Cunningham MW]
通讯作者: Cunningham MW
Gorillas with spondyloarthropathies express an MHC class I molecule with only limited sequence similarity to HLA-B27 that binds peptides with arginine at P2.
患有脊柱关节病的大猩猩表达的 MHC I 类分子与 HLA-B27 的序列相似性有限,HLA-B27 在 P2 处与精氨酸结合肽。
DOI: 10.4049/jimmunol.166.5.3334
发表时间: 2001
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者: [Urvater,JA, Hickman,H, Dzuris,JL, Prilliman,K, Allen,TM, Schwartz,KJ, Lorentzen,D, Shufflebotham,C, Collins,EJ, Neiffer,DL, Raphael,B, Hildebrand,W, Sette,A, Watkins,DI]
通讯作者: Watkins,DI
Anti-nuclear antibody production and autoimmunity in transgenic mice that overexpress the transcription factor Bright.
过度表达转录因子 Bright 的转基因小鼠的抗核抗体产生和自身免疫。
DOI: 10.4049/jimmunol.178.5.2996
发表时间: 2007
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者: [Shankar,Malini, Nixon,JameeC, Maier,Shannon, Workman,Jennifer, Farris,ADarise, Webb,CarolF]
通讯作者: Webb,CarolF
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    Molecular Basis of Immunity - Kirschstein - NRSA
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    Kidney injury molecular(KIM-1)介导肾小管上皮细胞自噬在糖尿病肾病肾间质纤维化中的作用
    • 批准号:
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    • 项目类别:
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    • 资助金额:
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    • 批准年份:
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    • 依托单位:
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