Biospecimen and Pathology Core
生物样本和病理学核心
基本信息
- 批准号:10473658
- 负责人:
- 金额:$ 9.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-18 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AmericanAmerican Society of Clinical OncologyArchivesBiological AssayBlood specimenClinicalClinical ResearchClinical TrialsCollectionCoupledCytometryDNA methylation profilingDataDiagnosticDrug or chemical Tissue DistributionEligibility DeterminationEvaluationExperimental DesignsGuidelinesHistologicHistologyHistopathologyHumanHuman ResourcesImageImmuneImmunogenomicsImmunohistochemistryImmunologicsIndividualInformaticsInfrastructureIschemiaMalignant neoplasm of ovaryPathologicPathologistPathologyPatientsPerformancePhenotypePreparationProcessProtocols documentationQuality ControlResearch PersonnelResearch Project GrantsResearch SupportSamplingScanningServicesSiteSlideSpecimenStandardizationT cell receptor repertoire sequencingTestingTimeTissue MicroarrayTissuesTrainingTranslational ResearchTumor TissueTumor-Infiltrating Lymphocytesautomated image analysisbasebiobankcollegedata disseminationdigitaldigital imagingexome sequencingexperienceimmunological statusinformatics infrastructureinterestlaser capture microdissectionnext generation sequencingovarian neoplasmsample fixationtissue resourcetooltranscriptome sequencingtumortumor microenvironment
项目摘要
ABSTRACT
The Roswell Park Ovarian Cancer SPORE Biospecimen & Pathology Core (BPC) combines a centralized
mechanism for expert tissue handling services and performance of tissue-based assays by highly qualified,
experienced personnel with a state-of-the-art integrated informatics infrastructure which provides tools for
tracking biospecimen collection, histopathological evaluation, and clinical annotation of samples with linkage to
immunogenomic and other translational data generated by the Individual Research Projects proposed in this
renewal application. The Core will collect, de-identify, process, bank, and distribute annotated, high-quality
tumor and blood samples from patients participating in SPORE-sponsored clinical studies. In addition, the BPC
will provide investigators with specialized technical and interpretative histopathology services including
expertise in multiplexed immunohistochemistry (IHC) and imaging mass cytometry (IMC), tissue microarray
construction, laser capture microdissection, digital imaging, and quantitative pathology review of slides, tumor-
infiltrating lymphocytes assessment, tissue QC/QA and preparation for next-gen sequencing-based assays
(whole exome seq, RNAseq, TCRseq, MethylSEQ), and oversight on optimal utilization of each biospecimen.
The Core will also be instrumental in testing patient biospecimens to determine eligibility for clinical trials and
directly add to the bi-directional translational science by a detailed immunological annotation of ovarian tumors.
摘要
项目成果
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- 批准号:
10026959 - 财政年份:2019
- 资助金额:
$ 9.86万 - 项目类别:














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