Pathology Resource Network

病理资源网

• 批准号: 8375982
• 负责人: CARL D MORRISON
• 金额: $ 47.16万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8375982
• 关键词: Antibodies; Archives; Basic Science; Blood Cells; Bone Marrow; Budgets; Businesses; Cancer Center Support Grant; Characteristics; Clinical; Collection; Core Facility; Cryopreserved Cell; DNA; Defect; Disease; Doctor of Philosophy; Dysmyelopoietic Syndromes; Ensure; Freezing; Fresh Tissue; Funding; Future; Genomics; Goals; Grant; Hematological Disease; Histology; Human; Human Resources; Image Analysis; Immunohistochemistry; In Situ Hybridization; Individual; Institutes; Institutional Review Boards; Laboratories; Leadership; Leukocytes; Liquid substance; Lymph Node Tissue; Malignant Neoplasms; Medicine; Mission; Molecular; Multiple Myeloma; Non-Hodgkin' s Lymphoma; Ohio; Organ; Paraffin; Paraffin Embedding; Pathogenesis; Pathology; Patients; Peer Review; Peripheral Blood Stem Cell; Process; Proteins; Protocols documentation; Publications; Quality Control; RNA; Recruitment Activity; Research; Research Personnel; Residual state; Resources; Role; Roswell Park Cancer Institute; Sampling; Services; Site; Solid; Solid Neoplasm; Specimen; Specimen Handling; Staging; Supervision; Surgical Pathology; System; Techniques; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; Translational Research; Universities; Work; base; granulocyte; human tissue; leukemia; leukemia tissue bank; macromolecule; meetings; member; molecular pathology; neoplastic; operation; prognostic; programs; repository; tissue resource; tumor

The Pathology Resource Network (previously Translational Research Tissue Support Resource) incorporates three functions, Tissue Procurement, Paraffin Archive and Leukemia Tissue Bank under the supervision of Carl Morrison, MD, DVM, Director of the Division of Molecular Pathology, Department of Pathology & Laboratory Medicine. Dr Morrison was recruited from The Ohio State University in January 2007. He has been responsible for reorganizing the Resource to meet Institute and CCSG requirements. This resource provides human specimens for basic and translational research to further the understanding of the cellular and molecular pathogenesis of human cancers. The overall goal is to facilitate access to human tissue for IRB-approved investigators with an emphasis on translational efforts. Tissue Procurement serves the traditional role of providing anonymous fresh and frozen tissue to investigators requiring unfixed human tissue. There are two major changes: (1) Tissue Procurement is making the necessary changes to transform a majority of requests to a macromolecule delivery (DMA, RNA, protein), allowing for a more efficient use of these precious materials by other CCSG Resources such as Microarray and Genomics and allowing multiple investigators to utilize a single specimen; (2) a procurement mechanism is being established to allow for special collections of tissues with an emphasis on translational research. The Paraffin Archive is a repository of organ-specific neoplastic and non-neoplastic formalinfixed, paraffin-embedded clinical specimens. There are two major changes: (1) the hiring of dedicated personnel under the supervision of Dr Morrison; (2) an intense effort to organize these specimens into a translational theme utilizing tissue microarrays. The Pathology Core Facility serves as a research specimen processing laboratory and performs functions for individual investigators and for Tissue Procurement and Paraffin Archive ranging from basic histology and immunohistochemistry to processing specimens for macromolecules for Tissue Procurement and building tissue microarrays for the Paraffin Archive. The Leukemia Tissue Bank processes and cryopreserves cell samples from patients with hematological disorders for analysis of a variety of molecular pathogenetic and prognostic characteristics. This highly-integrated Resource with well controlled and characterized specimens will continue to serve as an important resource for enhancing translational research and collaborative efforts that will result in increased peer-reviewed funding and publication. The Resource is used by all six Programs and 96% of users are CCSG members. $221,883 in CCSG support is requested, representing 19% of the total operating budget.

病理学资源网络（以前称为转化研究组织支持资源） 包含三个职能：组织采购、石蜡档案和白血病组织库 卡尔·莫里森 (Carl Morrison) 的监督，医学博士、兽医学博士、分子病理学部主任 病理学和检验医学。莫里森博士于一月份从俄亥俄州立大学招聘 2007 年。他负责重组资源以满足研究所和 CCSG 的要求。 该资源为基础和转化研究提供人类标本，以进一步了解 人类癌症的细胞和分子发病机制。总体目标是促进人类获取 为 IRB 批准的研究人员提供组织，重点是转化工作。 组织采购的传统作用是向以下组织提供匿名的新鲜和冷冻组织： 研究人员需要未固定的人体组织。主要有两个变化： (1) 组织采购 进行必要的改变，将大多数请求转变为大分子递送（DMA、RNA、 蛋白质），允许其他 CCSG 资源（例如 微阵列和基因组学，允许多个研究人员使用单个样本； （二）采购 正在建立机制，以允许特别收集组织，重点是转化 研究。石蜡档案库是器官特异性肿瘤和非肿瘤福尔马林固定的存储库， 石蜡包埋的临床标本。主要变化有二：（1）聘请专职人员。 莫里森博士监督下的人员； (2) 竭尽全力将这些样本组织成一个 利用组织微阵列的转化主题。病理学核心设施作为研究 样本处理实验室并为个体研究人员和组织履行职能 采购和石蜡档案，范围从基础组织学和免疫组织化学到加工 用于组织采购和构建石蜡组织微阵列的大分子样本 档案。白血病组织库处理并冷冻保存患有白血病的患者的细胞样本 用于分析血液学疾病的多种分子发病机制和预后特征。 这种高度集成的资源具有良好控制和表征的样本，将继续 作为加强转化研究和合作努力的重要资源，从而产生 增加同行评审的资助和出版物。 该资源由所有六个计划使用，96% 的用户是 CCSG 成员。 $221,883 于 请求 CCSG 支持，占总运营预算的 19%。