Pathology Resource Network

病理资源网

• 批准号: 8375982
• 负责人: CARL D MORRISON
• 金额: $ 47.16万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8375982
• 关键词: Antibodies; Archives; Basic Science; Blood Cells; Bone Marrow; Budgets; Businesses; Cancer Center Support Grant; Characteristics; Clinical; Collection; Core Facility; Cryopreserved Cell; DNA; Defect; Disease; Doctor of Philosophy; Dysmyelopoietic Syndromes; Ensure; Freezing; Fresh Tissue; Funding; Future; Genomics; Goals; Grant; Hematological Disease; Histology; Human; Human Resources; Image Analysis; Immunohistochemistry; In Situ Hybridization; Individual; Institutes; Institutional Review Boards; Laboratories; Leadership; Leukocytes; Liquid substance; Lymph Node Tissue; Malignant Neoplasms; Medicine; Mission; Molecular; Multiple Myeloma; Non-Hodgkin' s Lymphoma; Ohio; Organ; Paraffin; Paraffin Embedding; Pathogenesis; Pathology; Patients; Peer Review; Peripheral Blood Stem Cell; Process; Proteins; Protocols documentation; Publications; Quality Control; RNA; Recruitment Activity; Research; Research Personnel; Residual state; Resources; Role; Roswell Park Cancer Institute; Sampling; Services; Site; Solid; Solid Neoplasm; Specimen; Specimen Handling; Staging; Supervision; Surgical Pathology; System; Techniques; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; Translational Research; Universities; Work; base; granulocyte; human tissue; leukemia; leukemia tissue bank; macromolecule; meetings; member; molecular pathology; neoplastic; operation; prognostic; programs; repository; tissue resource; tumor

The Pathology Resource Network (previously Translational Research Tissue Support Resource) incorporates three functions, Tissue Procurement, Paraffin Archive and Leukemia Tissue Bank under the supervision of Carl Morrison, MD, DVM, Director of the Division of Molecular Pathology, Department of Pathology & Laboratory Medicine. Dr Morrison was recruited from The Ohio State University in January 2007. He has been responsible for reorganizing the Resource to meet Institute and CCSG requirements. This resource provides human specimens for basic and translational research to further the understanding of the cellular and molecular pathogenesis of human cancers. The overall goal is to facilitate access to human tissue for IRB-approved investigators with an emphasis on translational efforts. Tissue Procurement serves the traditional role of providing anonymous fresh and frozen tissue to investigators requiring unfixed human tissue. There are two major changes: (1) Tissue Procurement is making the necessary changes to transform a majority of requests to a macromolecule delivery (DMA, RNA, protein), allowing for a more efficient use of these precious materials by other CCSG Resources such as Microarray and Genomics and allowing multiple investigators to utilize a single specimen; (2) a procurement mechanism is being established to allow for special collections of tissues with an emphasis on translational research. The Paraffin Archive is a repository of organ-specific neoplastic and non-neoplastic formalinfixed, paraffin-embedded clinical specimens. There are two major changes: (1) the hiring of dedicated personnel under the supervision of Dr Morrison; (2) an intense effort to organize these specimens into a translational theme utilizing tissue microarrays. The Pathology Core Facility serves as a research specimen processing laboratory and performs functions for individual investigators and for Tissue Procurement and Paraffin Archive ranging from basic histology and immunohistochemistry to processing specimens for macromolecules for Tissue Procurement and building tissue microarrays for the Paraffin Archive. The Leukemia Tissue Bank processes and cryopreserves cell samples from patients with hematological disorders for analysis of a variety of molecular pathogenetic and prognostic characteristics. This highly-integrated Resource with well controlled and characterized specimens will continue to serve as an important resource for enhancing translational research and collaborative efforts that will result in increased peer-reviewed funding and publication. The Resource is used by all six Programs and 96% of users are CCSG members. $221,883 in CCSG support is requested, representing 19% of the total operating budget.

病理资源网络（以前转化研究组织支持资源） 结合了三个功能：组织采购，石蜡档案和白血病组织库 Carl Morrison，医学博士的监督，DVM，分子病理部主任，部门 病理与实验室医学。莫里森博士于1月从俄亥俄州立大学招募 2007年。他负责重组资源以满足研究所和CCSG要求。 该资源为基本和转化研究提供了人类标本，以进一步了解 人类癌的细胞和分子发病机理。总体目标是促进进入人类 IRB批准的研究人员的组织着重于翻译工作。 组织采购发挥了传统的作用，即提供匿名的新鲜和冷冻组织 需要未固定的人体组织的研究人员。有两个主要变化：（1）组织采购是 进行必要的更改以将大多数请求转换为大分子递送（DMA，RNA， 蛋白质），允许其他CCSG资源（例如 微阵列和基因组学，并允许多个研究人员使用单个标本； （2）采购 正在建立机制，以允许特殊的组织收集，重点是翻译 研究。石蜡档案是器官特异性肿瘤和非塑性词汇的存储库， 石蜡包裹的临床标本。有两个重大变化：（1）雇用专用 在莫里森博士的监督下； （2）将这些标本组织到一个 使用组织微阵列的翻译主题。病理学核心设施是一项研究 标本加工实验室并为单个研究人员和组织执行功能 采购和石蜡存档范围从基本的组织学和免疫组织化学到处理 用于组织采购的大分子标本和石蜡的组织微阵列 档案。白血病组织库的过程和冷冻保存来自患者的细胞样品 血液学障碍，用于分析各种分子致病和预后特征。 这种具有良好控制和特征标本的高度集成资源将继续 作为增强转化研究和协作努力的重要资源，这将导致 在增加同行评审的资金和出版物中。 所有六个程序都使用该资源，而96％的用户是CCSG成员。 $ 221,883英寸 请求CCSG支持，占总运营预算的19％。