Pathology Resource Network
病理资源网
基本信息
- 批准号:8375982
- 负责人:
- 金额:$ 47.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至 2014-04-30
- 项目状态:已结题
- 来源:
- 关键词:AntibodiesArchivesBasic ScienceBlood CellsBone MarrowBudgetsBusinessesCancer Center Support GrantCharacteristicsClinicalCollectionCore FacilityCryopreserved CellDNADefectDiseaseDoctor of PhilosophyDysmyelopoietic SyndromesEnsureFreezingFresh TissueFundingFutureGenomicsGoalsGrantHematological DiseaseHistologyHumanHuman ResourcesImage AnalysisImmunohistochemistryIn Situ HybridizationIndividualInstitutesInstitutional Review BoardsLaboratoriesLeadershipLeukocytesLiquid substanceLymph Node TissueMalignant NeoplasmsMedicineMissionMolecularMultiple MyelomaNon-Hodgkin&aposs LymphomaOhioOrganParaffinParaffin EmbeddingPathogenesisPathologyPatientsPeer ReviewPeripheral Blood Stem CellProcessProteinsProtocols documentationPublicationsQuality ControlRNARecruitment ActivityResearchResearch PersonnelResidual stateResourcesRoleRoswell Park Cancer InstituteSamplingServicesSiteSolidSolid NeoplasmSpecimenSpecimen HandlingStagingSupervisionSurgical PathologySystemTechniquesTissue BanksTissue MicroarrayTissue ProcurementsTissuesTranslational ResearchUniversitiesWorkbasegranulocytehuman tissueleukemialeukemia tissue bankmacromoleculemeetingsmembermolecular pathologyneoplasticoperationprognosticprogramsrepositorytissue resourcetumor
项目摘要
The Pathology Resource Network (previously Translational Research Tissue Support Resource)
incorporates three functions, Tissue Procurement, Paraffin Archive and Leukemia Tissue Bank under the
supervision of Carl Morrison, MD, DVM, Director of the Division of Molecular Pathology, Department of
Pathology & Laboratory Medicine. Dr Morrison was recruited from The Ohio State University in January
2007. He has been responsible for reorganizing the Resource to meet Institute and CCSG requirements.
This resource provides human specimens for basic and translational research to further the understanding of
the cellular and molecular pathogenesis of human cancers. The overall goal is to facilitate access to human
tissue for IRB-approved investigators with an emphasis on translational efforts.
Tissue Procurement serves the traditional role of providing anonymous fresh and frozen tissue to
investigators requiring unfixed human tissue. There are two major changes: (1) Tissue Procurement is
making the necessary changes to transform a majority of requests to a macromolecule delivery (DMA, RNA,
protein), allowing for a more efficient use of these precious materials by other CCSG Resources such as
Microarray and Genomics and allowing multiple investigators to utilize a single specimen; (2) a procurement
mechanism is being established to allow for special collections of tissues with an emphasis on translational
research. The Paraffin Archive is a repository of organ-specific neoplastic and non-neoplastic formalinfixed,
paraffin-embedded clinical specimens. There are two major changes: (1) the hiring of dedicated
personnel under the supervision of Dr Morrison; (2) an intense effort to organize these specimens into a
translational theme utilizing tissue microarrays. The Pathology Core Facility serves as a research
specimen processing laboratory and performs functions for individual investigators and for Tissue
Procurement and Paraffin Archive ranging from basic histology and immunohistochemistry to processing
specimens for macromolecules for Tissue Procurement and building tissue microarrays for the Paraffin
Archive. The Leukemia Tissue Bank processes and cryopreserves cell samples from patients with
hematological disorders for analysis of a variety of molecular pathogenetic and prognostic characteristics.
This highly-integrated Resource with well controlled and characterized specimens will continue to
serve as an important resource for enhancing translational research and collaborative efforts that will result
in increased peer-reviewed funding and publication.
The Resource is used by all six Programs and 96% of users are CCSG members. $221,883 in
CCSG support is requested, representing 19% of the total operating budget.
病理学资源网络(以前的转化研究组织支持资源)
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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CARL D MORRISON其他文献
CARL D MORRISON的其他文献
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