Pathology Network Shared Resource

病理网络共享资源

• 批准号: 10398057
• 负责人: CARL D MORRISON
• 金额: $ 26.66万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-16 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10398057
• 关键词: African American; Area; Basic Science; Biological Markers; Biological Specimen Banks; Breast Carcinoma; Cancer Center Support Grant; Cells; Clinical; Clinical Protocols; Clinical Trials; Collection; Complement; Comprehensive Cancer Center; Consent; Correlative Study; DNA; Data; Data Analyses; Development; Disease; Disease Resistance; Disseminated Malignant Neoplasm; Elements; Freezing; Fresh Tissue; Funding; Future; Genomics Shared Resource; Goals; Grant; Grant Review; Health Service Area; Hematologic Neoplasms; Histology; Human; Image; Image Analysis; Immune; Immunohistochemistry; Immunology; Individual; Industry; Institutional Review Boards; Laboratories; Lead; Leadership; Legal; Malignant Neoplasms; Malignant neoplasm of lung; Metastatic/Recurrent; Methods; Mission; Modeling; Operative Surgical Procedures; Pathogenesis; Pathology; Patients; Peer Review; Play; Preparation; Prevention; Process; RNA; Recurrence; Reporting; Research; Research Design; Research Personnel; Resource Sharing; Resources; Role; Sampling; Savings; Scanning; Science; Services; Site; Slide; Smoker; Solid Neoplasm; Specimen; Spectral Karyotyping; Standardization; System; Technology; The Cancer Genome Atlas; Time; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; Translational Research; Tumor Tissue; Work; automated image analysis; biobank; biomarker discovery; biomedical data science; cancer therapy; cell type; cohort; cost; data repository; design; functional status; implementation facilitation; instrumentation; laser capture microdissection; liquid crystal polymer; malignant breast neoplasm; member; non-smoker; operation; precision medicine; sample collection; spatial relationship; symposium; therapy resistant; tool; tumor

The Pathology Network Shared Resource (PNSR) provides human specimens and laboratory services for basic and translational research to further the understanding of the pathogenesis of human cancers and facilitate discovery of biomarkers for new precision medicine approaches. The overall mission of the PNSR is to facilitate collection and access to bio-specimens for research conducted at Roswell Park Comprehensive Cancer Center. The PNSR provides five key service areas: Procurement, Pathology Core Services, Correlative Science Pathology Office, Bio-specimen Bank, and Image Analysis. In the reporting period (2013-2017), the PNSR served a total of 202 Roswell users, of which 131 (88%) were CCSG members. The Specific Aims of the PNSR are: 1) To consent, collect, and store high quality tumor bio specimens. The PNSR oversees the consenting and collection of tumor specimens under a highly standardized process with IRB approval. This includes both routine surgical collections as well as specialized collections of metastatic disease, fresh tissue, or longitudinal collections in accordance with specific clinical protocols; 2) To provide state-of-the-art tissue analyses platforms. The PNSR provides a robust suite of tissue analysis tools to enable the comprehensive analysis of tissues. Standard histology and immunohistochemistry services are complemented by laser capture microdissection and spectral karyotyping; 3) To provide expertise for study design, grant preparation, and clinical trials. Staff within the PNSR plays an active role in designing biomarker studies and rigorous methods for evaluating data that emerges from the analysis of tissues. These integrated features of the PNSR provide an important platform for grant submissions and facilitate development of correlative studies in the context of clinical trials. There are limited options for bio specimen acquisition with the level of quality and annotation that is provided by the PNSR. Acquiring fresh or frozen tissue from external tissue banks is costly, requires considerable legal work (e.g. MTAs), and reliability can be questionable, our costs for these activities in comparison to external sites provide more affordable service for CCSG members. Furthermore, the convenience of these resources is an added benefit to investigators in terms of saving them time and ease of discussion related to design and interpretation of data. Services within the PNSR are accessible to any researcher that has appropriate IRB approval for the proposed work. The PNSR plans to be at the forefront in all areas of operation to facilitate cutting-edge research that will lead to significant changes in the prevention and treatment of cancer. Specialized procurement is critical for this goal given the importance of understanding metastatic, recurrent, and therapy resistant disease.

病理网络共享资源(PNSR)提供人体标本和实验室服务 基础和翻译研究，以进一步了解人类癌症的发病机制和 促进发现新的精准医学方法的生物标记物。PNSR的总体任务是 为在罗斯威尔公园综合体进行的研究收集和获取生物标本提供便利 癌症中心。PNSR提供五个关键服务领域：采购、病理核心服务、相关 科学病理办公室、生物标本库和图像分析。在本报告所述期间(2013-2017)， PNSR总共为202名罗斯威尔用户提供服务，其中131名(88%)是CCSG成员。的具体目标 PNSR是：1)同意、收集和存储高质量的肿瘤生物标本。PNSR负责监督 在IRB批准下，按照高度标准化的程序同意和收集肿瘤标本。这 既包括常规手术收集，也包括转移性疾病、新鲜组织、 或根据特定的临床方案进行纵向收集；2)提供最先进的组织 分析平台。PNSR提供一套强大的组织分析工具，以实现全面的 组织分析。标准的组织学和免疫组织化学服务由激光补充 捕获显微解剖和光谱核型分析；3)为研究设计、赠款准备、 和临床试验。PNSR的工作人员在设计生物标记物研究方面发挥了积极作用，并严格 用于评估从组织分析中出现的数据的方法。PNSR的这些集成功能 提供一个提交拨款申请的重要平台，并促进 临床试验的背景。由于生物标本的质量和水平不同，获取生物标本的选择有限 PNSR提供的注释。从外部组织库获取新鲜或冻结的组织是昂贵的， 需要大量的法律工作(例如MTA)，而且可靠性可能是值得怀疑的，我们这些活动的成本 与外部网站相比，网站为CCSG成员提供了更实惠的服务。此外， 这些资源的便利性对调查人员来说是一个额外的好处，可以节省他们的时间和方便 与数据设计和解释相关的讨论。任何人都可以访问PNSR中的服务 对提议的工作有适当IRB批准的研究人员。PNSR计划在#年走在前列 所有行动领域都要促进尖端研究，这将导致预防方面的重大变化 以及癌症的治疗。鉴于以下方面的重要性，专门采购对于这一目标至关重要 了解转移性、复发性和耐药疾病。