Pathology Network Shared Resource

病理网络共享资源

• 批准号: 10398057
• 负责人: CARL D MORRISON
• 金额: $ 26.66万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-16 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10398057
• 关键词: African American; Area; Basic Science; Biological Markers; Biological Specimen Banks; Breast Carcinoma; Cancer Center Support Grant; Cells; Clinical; Clinical Protocols; Clinical Trials; Collection; Complement; Comprehensive Cancer Center; Consent; Correlative Study; DNA; Data; Data Analyses; Development; Disease; Disease Resistance; Disseminated Malignant Neoplasm; Elements; Freezing; Fresh Tissue; Funding; Future; Genomics Shared Resource; Goals; Grant; Grant Review; Health Service Area; Hematologic Neoplasms; Histology; Human; Image; Image Analysis; Immune; Immunohistochemistry; Immunology; Individual; Industry; Institutional Review Boards; Laboratories; Lead; Leadership; Legal; Malignant Neoplasms; Malignant neoplasm of lung; Metastatic/Recurrent; Methods; Mission; Modeling; Operative Surgical Procedures; Pathogenesis; Pathology; Patients; Peer Review; Play; Preparation; Prevention; Process; RNA; Recurrence; Reporting; Research; Research Design; Research Personnel; Resource Sharing; Resources; Role; Sampling; Savings; Scanning; Science; Services; Site; Slide; Smoker; Solid Neoplasm; Specimen; Spectral Karyotyping; Standardization; System; Technology; The Cancer Genome Atlas; Time; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; Translational Research; Tumor Tissue; Work; automated image analysis; biobank; biomarker discovery; biomedical data science; cancer therapy; cell type; cohort; cost; data repository; design; functional status; implementation facilitation; instrumentation; laser capture microdissection; liquid crystal polymer; malignant breast neoplasm; member; non-smoker; operation; precision medicine; sample collection; spatial relationship; symposium; therapy resistant; tool; tumor

The Pathology Network Shared Resource (PNSR) provides human specimens and laboratory services for basic and translational research to further the understanding of the pathogenesis of human cancers and facilitate discovery of biomarkers for new precision medicine approaches. The overall mission of the PNSR is to facilitate collection and access to bio-specimens for research conducted at Roswell Park Comprehensive Cancer Center. The PNSR provides five key service areas: Procurement, Pathology Core Services, Correlative Science Pathology Office, Bio-specimen Bank, and Image Analysis. In the reporting period (2013-2017), the PNSR served a total of 202 Roswell users, of which 131 (88%) were CCSG members. The Specific Aims of the PNSR are: 1) To consent, collect, and store high quality tumor bio specimens. The PNSR oversees the consenting and collection of tumor specimens under a highly standardized process with IRB approval. This includes both routine surgical collections as well as specialized collections of metastatic disease, fresh tissue, or longitudinal collections in accordance with specific clinical protocols; 2) To provide state-of-the-art tissue analyses platforms. The PNSR provides a robust suite of tissue analysis tools to enable the comprehensive analysis of tissues. Standard histology and immunohistochemistry services are complemented by laser capture microdissection and spectral karyotyping; 3) To provide expertise for study design, grant preparation, and clinical trials. Staff within the PNSR plays an active role in designing biomarker studies and rigorous methods for evaluating data that emerges from the analysis of tissues. These integrated features of the PNSR provide an important platform for grant submissions and facilitate development of correlative studies in the context of clinical trials. There are limited options for bio specimen acquisition with the level of quality and annotation that is provided by the PNSR. Acquiring fresh or frozen tissue from external tissue banks is costly, requires considerable legal work (e.g. MTAs), and reliability can be questionable, our costs for these activities in comparison to external sites provide more affordable service for CCSG members. Furthermore, the convenience of these resources is an added benefit to investigators in terms of saving them time and ease of discussion related to design and interpretation of data. Services within the PNSR are accessible to any researcher that has appropriate IRB approval for the proposed work. The PNSR plans to be at the forefront in all areas of operation to facilitate cutting-edge research that will lead to significant changes in the prevention and treatment of cancer. Specialized procurement is critical for this goal given the importance of understanding metastatic, recurrent, and therapy resistant disease.

病理学网络共享资源 (PNSR) 提供人体标本和实验室服务 基础和转化研究，以进一步了解人类癌症的发病机制和 促进新精准医学方法的生物标志物的发现。 PNSR 的总体使命是 促进罗斯威尔公园综合中心进行的研究的生物样本的收集和获取 癌症中心。 PNSR 提供​​五个关键服务领域：采购、病理核心服务、相关服务 科学病理学办公室、生物样本库和图像分析。报告期内（2013-2017年）， PNSR 总共为 202 名罗斯威尔用户提供服务，其中 131 名（88%）是 CCSG 成员。具体目标 PNSR 是： 1) 同意、收集和储存高质量的肿瘤生物样本。 PNSR 负责监督 在IRB批准的高度标准化流程下同意和收集肿瘤标本。这 包括常规手术收集以及转移性疾病、新鲜组织、 或根据特定临床方案进行纵向收集； 2) 提供最先进的组织 分析平台。 PNSR 提供​​了一套强大的组织分析工具，以实现全面的 组织分析。激光补充了标准组织学和免疫组织化学服务 捕获显微解剖和光谱核型分析； 3）为研究设计、资助准备提供专业知识， 和临床试验。 PNSR 的工作人员在设计生物标志物研究和严格的 评估组织分析数据的方法。 PNSR 的这些集成功能 为资助申请提供重要平台，并促进相关研究的发展 临床试验的背景。生物样本采集的选择有限，质量水平和 PNSR 提供​​的注释。从外部组织库获取新鲜或冷冻组织的成本很高， 需要大量的法律工作（例如 MTA），并且可靠性可能值得怀疑，我们这些活动的成本 与外部网站相比，CCSG 会员可以提供更实惠的服务。此外， 这些资源的便利性对调查人员来说是一个额外的好处，可以节省他们的时间并方便他们进行调查。 与数据设计和解释相关的讨论。 PNSR 内的服务可供任何人使用 已获得 IRB 对拟议工作的适当批准的研究人员。 PNSR 计划走在前列 所有业务领域都将促进尖端研究，这将导致预防工作发生重大变化 和癌症的治疗。鉴于以下方面的重要性，专业化采购对于实现这一目标至关重要： 了解转移性、复发性和耐药性疾病。