Pathology Resource Network

病理资源网

• 批准号: 7714428
• 负责人: CARL D MORRISON
• 金额: $ 18.79万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-28 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7714428
• 关键词: Antibodies; Archives; Blood Cells; Bone Marrow; Budgets; Businesses; Cancer Center Support Grant; Characteristics; Clinical; Collection; Core Facility; Cryopreserved Cell; DNA; Defect; Defective spinal cord development; Disease; Doctor of Philosophy; Dysmyelopoietic Syndromes; Ensure; Facility Construction Funding Category; Freezing; Fresh Tissue; Funding; Future; Genomics; Goals; Hematological Disease; Histology; Human; Human Resources; Image Analysis; Immunohistochemistry; In Situ Hybridization; Individual; Institutes; Laboratories; Leadership; Leukocytes; Liquid substance; Lymph Node Tissue; Malignant Neoplasms; Medicine; Mission; Molecular; Multiple Myeloma; Non-Hodgkin' s Lymphoma; Numbers; Ohio; Operative Surgical Procedures; Organ; Paraffin; Paraffin Embedding; Pathogenesis; Pathology; Patients; Peer Review; Peripheral Blood Stem Cell; Process; Proteins; Protocols documentation; Publications; Purpose; Quality Control; Range; Recruitment Activity; Research; Research Ethics Committees; Research Personnel; Residual state; Resources; Role; Sampling; Services; Site; Solid; Solid Neoplasm; Specimen; Specimen Handling; Staging; Supervision; Surgical Pathology; System; Techniques; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; Translational Research; Universities; Work; base; day; granulocyte; human tissue; leukemia; macromolecule; member; molecular pathology; neoplastic; prognostic; programs; repository; tissue resource; tumor

The Pathology Resource Network (previously Translational Research Tissue Support Resource) incorporates three functions, Tissue Procurement, Paraffin Archive and Leukemia Tissue Bank under the supervision of Carl Morrison, MD, DVM, Director of the Division of Molecular Pathology, Department of Pathology & Laboratory Medicine. Dr Morrison was recruited from The Ohio State University in January 2007. He has been responsible for reorganizing the Resource to meet Institute and CCSG requirements. This resource provides human specimens for basic and translational research to further the understanding of the cellular and molecular pathogenesis of human cancers. The overall goal is to facilitate access to human tissue for IRB-approved investigators with an emphasis on translational efforts. Tissue Procurement serves the traditional role of providing anonymous fresh and frozen tissue to investigators requiring unfixed human tissue. There are two major changes: (1) Tissue Procurement is making the necessary changes to transform a majority of requests to a macromolecule delivery (DMA, RNA, protein), allowing for a more efficient use of these precious materials by other CCSG Resources such as Microarray and Genomics and allowing multiple investigators to utilize a single specimen; (2) a procurement mechanism is being established to allow for special collections of tissues with an emphasis on translational research. The Paraffin Archive is a repository of organ-specific neoplastic and non-neoplastic formalinfixed, paraffin-embedded clinical specimens. There are two major changes: (1) the hiring of dedicated personnel under the supervision of Dr Morrison; (2) an intense effort to organize these specimens into a translational theme utilizing tissue microarrays. The Pathology Core Facility serves as a research specimen processing laboratory and performs functions for individual investigators and for Tissue Procurement and Paraffin Archive ranging from basic histology and immunohistochemistry to processing specimens for macromolecules for Tissue Procurement and building tissue microarrays for the Paraffin Archive. The Leukemia Tissue Bank processes and cryopreserves cell samples from patients with hematological disorders for analysis of a variety of molecular pathogenetic and prognostic characteristics. This highly-integrated Resource with well controlled and characterized specimens will continue to serve as an important resource for enhancing translational research and collaborative efforts that will result in increased peer-reviewed funding and publication. The Resource is used by all six Programs and 96% of users are CCSG members. $221,883 in CCSG support is requested, representing 19% of the total operating budget.

病理学资源网络（以前的转化研究组织支持资源） 包括三个功能，组织采购，石蜡档案和白血病组织库下， 卡尔莫里森，医学博士，DVM，分子病理学系主任的监督 病理学和实验室医学。今年1月，莫里森博士从俄亥俄州州立大学受聘 2007.他负责重组资源，以满足研究所和CCSG的要求。 该资源为基础和转化研究提供了人类标本，以进一步了解 人类癌症的细胞和分子发病机制。总体目标是促进人类的获取 为IRB批准的研究者提供组织，重点是翻译工作。 组织采购的传统作用是提供匿名的新鲜和冷冻组织， 需要未固定人体组织的研究人员。有两个主要变化：（1）组织采购是 进行必要的改变以将大多数请求转换为大分子递送（DMA，RNA， 蛋白质），从而使其他CCSG资源更有效地利用这些珍贵材料， 微阵列和基因组学，并允许多个研究者使用单个样本;（2）采购 正在建立一种机制，以允许特别收集组织， research.石蜡档案是一个器官特异性肿瘤和非肿瘤福尔马林固定的储存库， 石蜡包埋的临床标本。有两大变化：（1）聘用专职 在莫里森博士的监督下，工作人员;（2）努力将这些标本组织成一个 利用组织微阵列的翻译主题。病理学核心设施作为一个研究 标本处理实验室并为个人研究者和组织履行职能 采购和石蜡存档，从基本组织学和免疫组织化学到处理 用于组织采购的大分子样品和用于石蜡的构建组织微阵列 存档。白血病组织库处理和冷冻保存来自白血病患者的细胞样本。 用于分析多种分子发病和预后特征的血液学疾病。 这一高度整合的资源与良好的控制和特点的标本将继续 作为一个重要的资源，以加强翻译研究和合作努力，将导致 在增加同行评审的资金和出版物。 该资源被所有六个计划使用，96%的用户是CCSG成员。221，883美元 要求CCSG提供的支助占业务预算总额的19%。