Biospecimen Core

生物样本核心

• 批准号: 9111883
• 负责人: CARL D MORRISON
• 金额: $ 0.13万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9111883
• 关键词: Archives; Basic Science; Clinical Trials; Collaborations; Collection; Early Detection Research Network; Eligibility Determination; Fred Hutchinson Cancer Research Center; Freezing; Histology; Human; Image; Immune; Immune response; Immunohistochemistry; MHC Class I Genes; Malignant Neoplasms; Malignant neoplasm of ovary; Ovarian; Pathology; Patient Care; Patients; Process; Research; Research Personnel; Research Project Grants; Science; Services; Site; Slide; Specialized Program of Research Excellence; Specimen; Testing; Tissue Microarray; Tissues; Translational Research; Tumor Antigens; University of Pittsburgh Cancer Institute; biobank; cancer testis antigen; digital imaging; immunological status; laser capture microdissection; ovarian neoplasm; programs; research study; tissue fixing; tissue processing; tissue resource; tumor; tumor microenvironment

The Biospecimen Core (BC) will provide essential services related to pathology for all projects of this Specialized Program of Research Excellence (SPORE). Each of the three sites (RPCI, UPCI, and Fred Hutchinson Cancer Research Center) in this SPORE will provide local services that are applicable to the project at the particular site. In addition to developing a high quality biospecimen bank, the BC will provide many other services to the SPORE investigators that include tissue microarrays, laser capture microdissection, general research histology services, immunohistochemistry, digital imaging, and pathology review of slides and images. In addition to services directly related to collection or processing of tissues, the BC will also be instrumental in testing of specimens for various markers to determine patient eligibility for the different clinical trials. The BC will directly add to the science of this ovarian SPORE by a detailed immunological annotation of ovarian tumors and the microenvironment.

生物化学核心(BC)将为这一专门的卓越研究计划(SPORT)的所有项目提供与病理学相关的基本服务。这三个地点中的每一个(RPCI、UPCI和弗雷德·哈钦森癌症研究中心)都将在特定地点提供适用于项目的当地服务。除了开发高质量的生物谱库外，BC还将为孢子调查人员提供许多其他服务，包括组织微阵列、激光捕获显微解剖、一般研究组织学服务、免疫组织化学、数字成像以及切片和图像的病理学审查。除了与组织收集或处理直接相关的服务外，BC还将帮助测试各种标记物的样本，以确定患者是否符合不同临床试验的条件。BC将通过对卵巢肿瘤和微环境的详细免疫学注释，直接增加对这种卵巢孢子的科学研究。