Quantification of Tics in Tourette Syndrome
抽动秽语综合征抽动的量化
基本信息
- 批准号:10635872
- 负责人:
- 金额:$ 61.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-05-15 至 2028-04-30
- 项目状态:未结题
- 来源:
- 关键词:AdultAffectAftercareAgreementAlgorithmsAttention deficit hyperactivity disorderBenchmarkingBlinkingChildChildhoodChronicClassificationClinicalClinical DataClinical ResearchClinical TrialsClinical assessmentsCodeCommunitiesComputational algorithmComputer Vision SystemsDataData SetDecision MakingDetectionDevelopmentDiagnosisDiagnosticDisparity in diagnosisDyskinetic syndromeEducationEventEyeFaceFrequenciesGilles de la Tourette syndromeGoalsHeadHealth Services AccessibilityHealthcareHumanIndividualInternetInterviewKnowledgeLabelLeftMachine LearningManualsMeasurementMeasuresMedicalMental DepressionMethodsMonitorMotor TicsMovementNeurodevelopmental DisorderNeurologyPaperParkinson DiseasePatient EducationPatientsPersonsPharmaceutical PreparationsPhenotypeProspective cohortProviderPsychiatryPsychologyQuestionnairesResearchSamplingSeveritiesShoulderSymptomsSystemTechniquesTechnologyTestingTimeTrainingUnderrepresented PopulationsVision researchVocal TicsWorkclinical careclinical diagnosticsclinically relevantcomputer sciencedata acquisitionethnoracial disparityexperiencefeature extractioninsightlearning algorithmlearning strategymachine learning methodminority childrenmovement analysisnovelpatient subsetsphenomenological modelsprospective testpsychostimulantracial minorityscreeningsupervised learningtic suppressiontoolvocalization
项目摘要
PROJECT SUMMARY/ABSTRACT
Tourette Syndrome (TS) is a chronic, childhood-onset neurodevelopmental disorder that affects 1-3% of people
and is associated with adverse functional impacts. TS is characterized by tics, which are involuntary, repetitive
movements and vocalizations. A current challenge in clinical care for TS is the lack of objective, quantitative,
scalable tools to measure tics for the purposes of diagnosis and symptom severity monitoring. The overall
objective of the proposed study is to use video-based methods in a large, diverse community sample to inform
quantitative and automated phenotyping of tics. This study builds on prior work, including: 1) video-based
observational methods with trained human raters to quantify tics for research purposes, 2) computer vision and
machine learning techniques for movement analysis and medical diagnostic aids, and 3) preliminary data
indicating supervised learning methods can be used to automate detection of eye tics with high accuracy. In
Aim 1, videos and clinical data from N = 1,000 individuals with tics will be collected using remote and
internet-based methods. A deep phenotyping approach will be used to quantitatively describe the phenotypic
spectrum of observable motor and vocal tics, empirically derive tic severity benchmarks, and identify patient
subgroups. In Aim 2, our computer vision team will apply supervised machine learning methods to Aim 1 data
to create an algorithm capable of detecting the most common tics. Aim 3 will prospectively test the Aim 2
algorithm in N = 60 patients who completed TS treatment in a separate clinical trial to establish the algorithm’s
sensitivity to change and convergent validity with current gold-standard tic severity measurement. This project
will enable us, for the first time, to quantify the spectrum of observable tics in a large community sample,
knowledge that will have immediate clinical relevance for diagnostic decision making and patient education.
Aim 2 will yield a computer algorithm capable of autonomously quantifying the most common motor tics, a
critical next step toward developing accurate, clinically valid, and scalable assessments for tic screening,
diagnosis, treatment decision making, and symptom quantification in clinical trials.
项目总结/文摘
项目成果
期刊论文数量(0)
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Christine A Conelea其他文献
Christine A Conelea的其他文献
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{{ truncateString('Christine A Conelea', 18)}}的其他基金
Multimodal Profiling of Response to Pediatric Comprehensive Behavioral Intervention for Tics
儿科抽动综合行为干预反应的多模式分析
- 批准号:
10743782 - 财政年份:2023
- 资助金额:
$ 61.11万 - 项目类别:
Transcranial Magnetic Stimulation to Augment Behavior Therapy for Tics
经颅磁刺激增强抽动行为疗法
- 批准号:
10041139 - 财政年份:2020
- 资助金额:
$ 61.11万 - 项目类别:
Integrative Examination of Neurobehavioral Mechanisms in Tic Suppression
抽动抑制中神经行为机制的综合检查
- 批准号:
9297368 - 财政年份:2017
- 资助金额:
$ 61.11万 - 项目类别:
Integrative Examination of Neurobehavioral Mechanisms in Tic Suppression
抽动抑制中神经行为机制的综合检查
- 批准号:
9103252 - 财政年份:2015
- 资助金额:
$ 61.11万 - 项目类别:
Integrative Examination of Neurobehavioral Mechanisms in Tic Suppression
抽动抑制中神经行为机制的综合检查
- 批准号:
8876805 - 财政年份:2014
- 资助金额:
$ 61.11万 - 项目类别:
Integrative Examination of Neurobehavioral Mechanisms in Tic Suppression
抽动抑制中神经行为机制的综合检查
- 批准号:
8678125 - 财政年份:2014
- 资助金额:
$ 61.11万 - 项目类别:
Characterization and Treatment of Sensory Intolerance in Childhood
儿童期感觉不耐受的特征和治疗
- 批准号:
8508699 - 财政年份:2012
- 资助金额:
$ 61.11万 - 项目类别:
Characterization and Treatment of Sensory Intolerance in Childhood
儿童期感觉不耐受的特征和治疗
- 批准号:
8308123 - 财政年份:2012
- 资助金额:
$ 61.11万 - 项目类别:
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