Multimodal Profiling of Response to Pediatric Comprehensive Behavioral Intervention for Tics

儿科抽动综合行为干预反应的多模式分析

基本信息

  • 批准号:
    10743782
  • 负责人:
  • 金额:
    $ 79.23万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-12 至 2028-08-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY The overall objective of this proposal is to conduct the first mechanistic clinical trial of pediatric Comprehensive Behavioral Intervention for Tics (CBIT) to identify bio-behavioral predictors and correlates of response and the most potent aspects of CBIT delivery. Chronic tics affect 1-3% of youth in the US and are a disabling neuropsychiatric symptom associated with multiple childhood-onset mental disorders. CBIT is the current first-line, gold-standard treatment for tics and focuses on skills to enhance voluntary tic suppression and reduce tic triggers. However, about 50% of youth do not benefit from CBIT. The current study aims to use multimodal measurements to identify predictors of response (for whom does CBIT work?), the therapeutic processes that activate change (what are the potent aspects of CBIT delivery?), and correlates of response (what changes occur in patients whose tics improve?). Study hypotheses, based on the literature and our preliminary data, predict that CBIT relies upon, engages, and strengthens connectivity within and between functional brain networks that support top-down control over motor functions. Youth ages 10-17 years with chronic tics (N = 100) will complete a course of 8 outpatient, weekly sessions of CBIT and pre-, post-, and 3-month follow up assessments. Multimodal assessments will include: 1) neural measures of functional connectivity among the brain's large-scale functional networks using fMRI and EEG during rest and tic expression and suppression, 2) direct-observation behavioral measurement of tics, and 3) psychosocial measures, including assessments of clinical symptoms and patient-centered outcome measures informed by preliminary data and our Patient Advisory Board. CBIT process will be assessed via a novel video-based behavioral coding of CBIT sessions. This project has the potential to directly benefit patients both immediately and in the long-term. Results will have a downstream impact on clinical practice by informing individualized treatment planning and efforts to streamline and improve CBIT quality. Results will also have an upstream impact on treatment development by identifying novel neural targets for intervention and strategies for improving CBIT outcomes via refinement or adjunctive procedures.
项目总结

项目成果

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会议论文数量(0)
专利数量(0)

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Christine A Conelea其他文献

Christine A Conelea的其他文献

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{{ truncateString('Christine A Conelea', 18)}}的其他基金

Quantification of Tics in Tourette Syndrome
抽动秽语综合征抽动的量化
  • 批准号:
    10635872
  • 财政年份:
    2023
  • 资助金额:
    $ 79.23万
  • 项目类别:
Transcranial Magnetic Stimulation to Augment Behavior Therapy for Tics
经颅磁刺激增强抽动行为疗法
  • 批准号:
    10041139
  • 财政年份:
    2020
  • 资助金额:
    $ 79.23万
  • 项目类别:
Integrative Examination of Neurobehavioral Mechanisms in Tic Suppression
抽动抑制中神经行为机制的综合检查
  • 批准号:
    9297368
  • 财政年份:
    2017
  • 资助金额:
    $ 79.23万
  • 项目类别:
Integrative Examination of Neurobehavioral Mechanisms in Tic Suppression
抽动抑制中神经行为机制的综合检查
  • 批准号:
    9103252
  • 财政年份:
    2015
  • 资助金额:
    $ 79.23万
  • 项目类别:
Integrative Examination of Neurobehavioral Mechanisms in Tic Suppression
抽动抑制中神经行为机制的综合检查
  • 批准号:
    8876805
  • 财政年份:
    2014
  • 资助金额:
    $ 79.23万
  • 项目类别:
Integrative Examination of Neurobehavioral Mechanisms in Tic Suppression
抽动抑制中神经行为机制的综合检查
  • 批准号:
    8678125
  • 财政年份:
    2014
  • 资助金额:
    $ 79.23万
  • 项目类别:
Characterization and Treatment of Sensory Intolerance in Childhood
儿童期感觉不耐受的特征和治疗
  • 批准号:
    8508699
  • 财政年份:
    2012
  • 资助金额:
    $ 79.23万
  • 项目类别:
Characterization and Treatment of Sensory Intolerance in Childhood
儿童期感觉不耐受的特征和治疗
  • 批准号:
    8308123
  • 财政年份:
    2012
  • 资助金额:
    $ 79.23万
  • 项目类别:

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