Characterization and Treatment of Sensory Intolerance in Childhood

儿童期感觉不耐受的特征和治疗

• 批准号: 8508699
• 负责人: Christine A Conelea
• 金额: $ 5.48万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8508699
• 关键词: Address; Adult; Anxiety; Attention deficit hyperactivity disorder; Auditory; Autistic Disorder; Behavioral; Categories; Characteristics; Child; Childhood; Chronic; Clinic; Clinical; Data; Development; Developmental Therapeutics Program; Diagnosis; Diagnostic; Dimensions; Disease; Distress; Emotional; Epidemiology; Esthesia; Family Leave; Funding; Future; Gilles de la Tourette syndrome; Goals; Grant; High Prevalence; Impairment; Intervention; Life; Maintenance; Manuscripts; Medicaid; Mental disorders; Mentorship; National Institute of Child Health and Human Development; National Research Service Awards; Obsessive-Compulsive Disorder; Preparation; Prevalence; Primary Health Care; Psychopathology; Recruitment Activity; Research; Research Personnel; Research Technics; Research Training; Sampling; School-Age Population; Sensory; Staging; Stimulus; Structure; Symptoms; Tactile; Testing; Time; Training; Writing; base; career; cost; design; experience; functional disability; novel; psychologic; research and development; response; sensory integration; sensory stimulus; skills; social; statistics; theories; therapy development

DESCRIPTION (provided by applicant): This F32 National Research Service Award is designed to help the PI achieve her long-term career goal of becoming an independent investigator with lines of research focused on understanding the phenomenology and treatment of obsessive-compulsive spectrum disorders. Consistent with this goal, the proposed study will focus on extending the PI's research to the characterization and treatment of sensory intolerance (SI) in childhood. SI is an exaggerated, intense, and/or prolonged behavioral response toward certain sensations, such as tactile or auditory input. SI is a chronic condition associated with significant distress and functional impairment that may set the stage for the development of psychopathology later in life. Despite the high prevalence rate of SI, there are large gaps in the understanding of SI phenomenology and treatment that could be addressed by psychiatric research. Although SI is thought to cut across current diagnostic categories, little is known about the relationship of SI to other psychiatric disorders and symptom dimensions, information that is critical for future treatment development. In addition, there is a lack of available empirically- based treatment for SI. Thus, the overall aims of the current study are to 1) recruit 46 children from primary care clinics with SI complaints and conduct a comprehensive, clinician-administered assessment to better characterize and define SI and 2) pilot-test an exposure-based treatment in six children with primary SI symptoms using a multiple baseline design. The long term goal of the proposed study is designed to generate preliminary data necessary to begin a line of research focused on a) understanding the phenomenology, development, and maintenance of SI and b) developing an empirically supported intervention for SI. The highly structured training plan in the current application is ideally suited to allow the I to conduct the proposed research plan and to move towards her long-term career goals. The PI will receive training in 1) assessment, characterization, and clinical presentation of SI, 2) treatment development research techniques, 3) exposure-based therapy, 4) advanced statistics, and 5) manuscript preparation and grant writing skills. Training will be guided by an expert mentorship team with expertise in SI, exposure therapy, developmental psychopathology, and treatment development. Therefore, the proposed training and research plans will provide the PI with experiences necessary to accomplish her ultimate goal of becoming an independent investigator.

该F32国家研究服务奖旨在帮助PI实现她的长期职业目标，成为一名独立的研究人员，其研究重点是了解强迫性谱系障碍的现象学和治疗。与这一目标相一致，拟议的研究将侧重于将PI的研究扩展到儿童感觉不耐受（SI）的表征和治疗。SI是对某些感觉（如触觉或听觉输入）的夸张、强烈和/或延长的行为反应。SI是一种慢性疾病，与严重的痛苦和功能障碍有关，可能为以后的生活中精神病理学的发展奠定基础。尽管SI的患病率很高，但对SI现象学和治疗的理解存在很大差距，可以通过精神病学研究来解决。虽然SI被认为是跨越目前的诊断类别， 了解SI与其他精神疾病和症状维度的关系，这些信息对未来的治疗开发至关重要。此外，缺乏对SI的可用的基于经验的治疗。因此，本研究的总体目标是：1）从初级保健诊所招募46名患有SI投诉的儿童，并进行全面的临床医生管理的评估，以更好地表征和定义SI; 2）使用多基线设计，在6名患有原发性SI症状的儿童中对基于胰岛素的治疗进行初步测试。拟议研究的长期目标旨在生成必要的初步数据，以便开始一系列研究，重点是a）理解SI的现象学、发展和维持，以及B）开发一种经验支持的SI干预措施。 当前应用程序中高度结构化的培训计划非常适合让我进行拟议的研究计划，并朝着她的长期职业目标迈进。主要研究者将接受以下方面的培训：1）SI的评估、表征和临床表现，2）治疗开发研究技术，3）基于胰岛素的治疗，4）高级统计学，以及5）手稿准备和资助写作技能。培训将由一个在SI，暴露疗法，发展精神病理学和治疗开发方面具有专业知识的专家导师团队指导。因此，拟定的培训和研究计划将为PI提供必要的经验，以实现其成为独立研究者的最终目标。

项目成果

The role of parental perceptions of tic frequency and intensity in predicting tic-related functional impairment in youth with chronic tic disorders.

• DOI: 10.1007/s10578-013-0434-2
• 发表时间: 2014-12
• 期刊: CHILD PSYCHIATRY & HUMAN DEVELOPMENT
• 影响因子: 2.9
• 作者: Espil, Flint M.;Capriotti, Matthew R.;Conelea, Christine A.;Woods, Douglas W.
• 通讯作者: Woods, Douglas W.

The sense of incompleteness as a motivator of obsessive-compulsive symptoms: an empirical analysis of concepts and correlates.

不完整感作为强迫症状的动机：概念和相关性的实证分析。

• DOI: 10.1016/j.beth.2013.11.004
• 发表时间: 2014
• 期刊: Behavior therapy
• 影响因子: 3.7
• 作者: Taylor,Steven;McKay,Dean;Crowe,KatherineB;Abramowitz,JonathanS;Conelea,ChristineA;Calamari,JohnE;Sica,Claudio
• 通讯作者: Sica,Claudio

Sensory over-responsivity in a sample of children seeking treatment for anxiety.

• DOI: 10.1097/dbp.0000000000000092
• 发表时间: 2014-10
• 期刊: Journal of developmental and behavioral pediatrics : JDBP
• 作者: Conelea CA;Carter AC;Freeman JB
• 通讯作者: Freeman JB

Sensory intolerance: latent structure and psychopathologic correlates.

感觉不耐受：潜在结构和精神病理学相关性。

• DOI: 10.1016/j.comppsych.2014.03.007
• 发表时间: 2014
• 期刊: Comprehensive psychiatry
• 影响因子: 7.3
• 作者: Taylor,Steven;Conelea,ChristineA;McKay,Dean;Crowe,KatherineB;Abramowitz,JonathanS
• 通讯作者: Abramowitz,JonathanS