Transcranial Magnetic Stimulation to Augment Behavior Therapy for Tics
经颅磁刺激增强抽动行为疗法
基本信息
- 批准号:10041139
- 负责人:
- 金额:$ 124.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-10 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdolescentAdverse eventAffectAftercareAgeAnalysis of VarianceAreaBehaviorBehavior TherapyBehavior assessmentBehavioralBrainChildChildhoodChronicClinicalClinical assessmentsCorpus striatum structureDataDevelopmentDoseDouble-Blind MethodFunctional Magnetic Resonance ImagingGilles de la Tourette syndromeGoldHyperactive behaviorInterventionLinkLiteratureMeasuresMediatingMental disordersModelingMotorMotor CortexMovementOutcomePathway interactionsPatientsPhasePilot ProjectsRandomizedRegimenResearchRestSafetySamplingSeveritiesSymptomsTestingTic disorderTimeTranscranial magnetic stimulationYouthassociated symptombasecontrol trialdesignelectric fieldfollow-upfunctional outcomesimprovedneuromechanismneuropsychiatric symptomputamenrepetitive transcranial magnetic stimulationresponsetic suppressionvocalization
项目摘要
PROJECT SUMMARY/ABSTRACT
Chronic tics affect 1-3% of youth in the US and are a disabling neuropsychiatric symptom associated with
multiple childhood-onset mental disorders. Tic suppression using Comprehensive Behavioral Intervention for
Tics (CBIT) is the current first-line, gold-standard therapy for tics. However, many patients do not fully benefit
from CBIT, likely because they lack the fundamental tic suppression ability that CBIT aspires to enhance. Our
preliminary data and the literature show that tic suppression ability can be enhanced with inhibitory repetitive
transcranial magnetic stimulation (rTMS) of the supplementary motor area (SMA). SMA is a key node of
cortico-striatal circuits and is known to be hyperactive and hyperconnected in tic disorders. We therefore
anticipate that combining CBIT with inhibitory stimulation of SMA may facilitate higher CBIT response rates.
This study will test whether augmenting CBIT with inhibitory, noninvasive stimulation of SMA normalizes
activity in SMA-mediated circuits and enhances tic suppression ability in young people with tic disorder. The
R61 phase will compare two rTMS regimens, 1 Hz rTMS and continuous theta burst stimulation (cTBS),
against sham stimulation. R61 aims will test engagement of brain (SMA-mediated circuits) and behavior (tic
suppression ability) targets and identify the optimal rTMS regimen. To this end, 60 youth ages 12-21 years with
chronic tics will complete 10 daily sessions of CBIT plus randomly assigned rTMS regimen, with fMRI,
behavioral, and clinical assessments before and after treatment. The R33 phase will investigate the effects of
CBIT augmentation with the optimal rTMS regimen in a double blinded randomized control trial in a new
sample of 60 youth with chronic tics. R33 aims test the link between target engagement and functional
outcomes, examine the clinical trajectory of the dose-response relationship, and assess intervention durability
at 1 month follow-up. TMS targeting in both phases will be informed by individualized electric field modeling.
This project will establish CBIT+rTMS as a treatment for chronic tics and provide a model for mechanistically
studying pediatric interventions combining behavior therapy with neurostimulation. Results from this line of
research will inform TMS therapy augmentation strategies and improve our understanding of neural
mechanisms underlying CBIT, TMS, and tics.
项目总结/摘要
慢性抽搐影响美国1-3%的青少年,是一种致残性神经精神症状,
儿童期发作的多重精神障碍抽动抑制使用综合行为干预
抽动症(CBIT)是目前治疗抽动症的一线、金标准疗法。然而,许多患者并没有完全受益
从CBIT,可能是因为他们缺乏基本的抽搐抑制能力,CBIT渴望提高。我们
初步数据和文献表明,抑制性重复动作可以增强抽动抑制能力,
辅助运动区(SMA)的经颅磁刺激(rTMS)。SMA是一个关键节点,
皮质-纹状体回路,并且已知在抽动障碍中过度活跃和过度连接。因此我们
预期将CBIT与SMA的抑制性刺激组合可促进更高的CBIT响应率。
本研究将测试通过抑制性、非侵入性刺激SMA来增强CBIT是否正常化
活动SMA介导的电路和增强抽动障碍的年轻人的抽动抑制能力。的
R61阶段将比较两种rTMS方案,1 Hz rTMS和连续θ波群刺激(cTBS),
对抗假刺激R61 aims将测试大脑(SMA介导的回路)和行为(tic
抑制能力)的目标,并确定最佳的rTMS方案。为此,60名12至21岁的青年,
慢性抽搐将完成10次每日CBIT加上随机分配的rTMS方案,使用fMRI,
治疗前后的行为和临床评估。R33阶段将研究以下因素的影响:
在一项新的双盲随机对照试验中使用最佳rTMS方案进行CBIT增强
60例慢性抽动症青年患者。R33旨在测试目标参与度和功能之间的联系
结果,检查剂量-反应关系的临床轨迹,并评估干预的持久性
1个月随访时。两个阶段的TMS靶向将通过个性化电场建模进行通知。
该项目将建立CBIT+rTMS作为慢性抽动的治疗方法,并提供一个模型,
研究儿科干预结合行为疗法和神经刺激。这条线的结果
研究将为TMS治疗增强策略提供信息,并提高我们对神经系统疾病的理解。
CBIT、TMS和抽搐的潜在机制。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Considerations for Pairing Cognitive Behavioral Therapies and Non-invasive Brain Stimulation: Ignore at Your Own Risk.
- DOI:10.3389/fpsyt.2021.660180
- 发表时间:2021
- 期刊:
- 影响因子:4.7
- 作者:Conelea CA;Jacob S;Redish AD;Ramsay IS
- 通讯作者:Ramsay IS
The CBIT+TMS Trial: study protocol for a two-phase randomized controlled trial testing neuromodulation to augment behavior therapy for youth with chronic tics.
CBIT TMS 试验:两阶段随机对照试验的研究方案,测试神经调节以增强患有慢性抽动症的青少年的行为治疗。
- DOI:10.21203/rs.3.rs-2949388/v1
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Conelea,Christine;Greene,Deanna;Alexander,Jennifer;Houlihan,Kerry;Hodapp,Sarah;Wellen,Brianna;Francis,Sunday;Mueller,Bryon;Hendrickson,Timothy;Tseng,Angela;Chen,Mo;Fiecas,Mark;Lim,Kelvin;Opitz,Alexander;Jacob,Suma
- 通讯作者:Jacob,Suma
The CBIT + TMS trial: study protocol for a two-phase randomized controlled trial testing neuromodulation to augment behavior therapy for youth with chronic tics.
- DOI:10.1186/s13063-023-07455-1
- 发表时间:2023-07-03
- 期刊:
- 影响因子:2.5
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Christine A Conelea其他文献
Christine A Conelea的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Christine A Conelea', 18)}}的其他基金
Multimodal Profiling of Response to Pediatric Comprehensive Behavioral Intervention for Tics
儿科抽动综合行为干预反应的多模式分析
- 批准号:
10743782 - 财政年份:2023
- 资助金额:
$ 124.89万 - 项目类别:
Integrative Examination of Neurobehavioral Mechanisms in Tic Suppression
抽动抑制中神经行为机制的综合检查
- 批准号:
9297368 - 财政年份:2017
- 资助金额:
$ 124.89万 - 项目类别:
Integrative Examination of Neurobehavioral Mechanisms in Tic Suppression
抽动抑制中神经行为机制的综合检查
- 批准号:
9103252 - 财政年份:2015
- 资助金额:
$ 124.89万 - 项目类别:
Integrative Examination of Neurobehavioral Mechanisms in Tic Suppression
抽动抑制中神经行为机制的综合检查
- 批准号:
8876805 - 财政年份:2014
- 资助金额:
$ 124.89万 - 项目类别:
Integrative Examination of Neurobehavioral Mechanisms in Tic Suppression
抽动抑制中神经行为机制的综合检查
- 批准号:
8678125 - 财政年份:2014
- 资助金额:
$ 124.89万 - 项目类别:
Characterization and Treatment of Sensory Intolerance in Childhood
儿童期感觉不耐受的特征和治疗
- 批准号:
8508699 - 财政年份:2012
- 资助金额:
$ 124.89万 - 项目类别:
Characterization and Treatment of Sensory Intolerance in Childhood
儿童期感觉不耐受的特征和治疗
- 批准号:
8308123 - 财政年份:2012
- 资助金额:
$ 124.89万 - 项目类别:
相似海外基金
Exploring the mental health and wellbeing of adolescent parent families affected by HIV in South Africa
探讨南非受艾滋病毒影响的青少年父母家庭的心理健康和福祉
- 批准号:
ES/Y00860X/1 - 财政年份:2024
- 资助金额:
$ 124.89万 - 项目类别:
Fellowship
Scaling-up co-designed adolescent mental health interventions
扩大共同设计的青少年心理健康干预措施
- 批准号:
MR/Y020286/1 - 财政年份:2024
- 资助金额:
$ 124.89万 - 项目类别:
Fellowship
Shared Spaces: The How, When, and Why of Adolescent Intergroup Interactions
共享空间:青少年群体间互动的方式、时间和原因
- 批准号:
ES/T014709/2 - 财政年份:2024
- 资助金额:
$ 124.89万 - 项目类别:
Research Grant
Social Media Mechanisms Affecting Adolescent Mental Health (SoMe3)
影响青少年心理健康的社交媒体机制 (SoMe3)
- 批准号:
MR/X034925/1 - 财政年份:2024
- 资助金额:
$ 124.89万 - 项目类别:
Fellowship
Parent-adolescent informant discrepancies: Predicting suicide risk and treatment outcomes
父母与青少年信息差异:预测自杀风险和治疗结果
- 批准号:
10751263 - 财政年份:2024
- 资助金额:
$ 124.89万 - 项目类别:
Adolescent sugar overconsumption programs food choices via altered dopamine signalling
青少年糖过度消费通过改变多巴胺信号来影响食物选择
- 批准号:
BB/Y006496/1 - 财政年份:2024
- 资助金额:
$ 124.89万 - 项目类别:
Research Grant
The Impact of Online Social Interactions on Adolescent Cognition
在线社交互动对青少年认知的影响
- 批准号:
DE240101039 - 财政年份:2024
- 资助金额:
$ 124.89万 - 项目类别:
Discovery Early Career Researcher Award
Resilience Factors, Pain, and Physical Activity in Adolescent Chronic Musculoskeletal Pain
青少年慢性肌肉骨骼疼痛的弹性因素、疼痛和体力活动
- 批准号:
10984668 - 财政年份:2024
- 资助金额:
$ 124.89万 - 项目类别:
Augmented Social Play (ASP): smartphone-enabled group psychotherapeutic interventions that boost adolescent mental health by supporting real-world connection and sense of belonging
增强社交游戏 (ASP):智能手机支持的团体心理治疗干预措施,通过支持现实世界的联系和归属感来促进青少年心理健康
- 批准号:
10077933 - 财政年份:2023
- 资助金额:
$ 124.89万 - 项目类别:
EU-Funded
Family-Focused Adolescent & Lifelong Health Promotion (FLOURISH)
以家庭为中心的青少年
- 批准号:
10050850 - 财政年份:2023
- 资助金额:
$ 124.89万 - 项目类别:
EU-Funded