Single Cell Spatial Transcriptomics Shared Instrument at the BCM Core Facility

BCM 核心设施的单细胞空间转录组学共享仪器

基本信息

  • 批准号:
    10414324
  • 负责人:
  • 金额:
    $ 30.4万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-01 至 2023-07-31
  • 项目状态:
    已结题

项目摘要

Abstract Single-cell omics is a rapidly growing new field that provides many advantages over traditional ‘bulk’ tissue profiling methods, such as the ability to resolve intratissue heterogeneity in cell types, profile disease microenvironments, and study rare subpopulations. However, one of the major drawbacks of current single-cell transcriptome technologies is that they require the isolation of single cells, resulting in the loss of spatial information. To address this issue, spatial single-cell transcriptomics technologies have been recently developed, which will enable many new research opportunities. The requested instrument, the MERSCOPE from Vizgen, is currently the only commercial platform for the recently developed multiplexed error-robust fluorescence in situ hybridization (MERFISH) technology that allows in situ transcriptome profiling at single cell resolution. By utilizing error-robust and error-correcting encoding schemes, MERFISH enables massively multiplexed single-molecule RNA imaging with high sensitivity and accuracy. The shared MERSCOPE instrument will be placed at and administrated by the established BCM Single Cell Genomics Core (SCGC) to ensure smooth operation and easy access. We have identified 16 research groups at BCM as users. Together, these groups have 41 active research projects funded by the NIH and will use 90% of the capacity of the instrument. The research focuses of these projects are highly diverse, and they are funded by fifteen institutes at the NIH, including the NICHD, NIAMS, NIDC, NCATS, NIDDK, NEI, NCI, NIA, NIGMS, NHLBI, NHGRI, NINDS, NIAID, NIEHS, and NIMDH. As the participating PIs are all engaged in both basic and clinical research, we believe the introduction of this new instrument will have direct, broad, and immediate impact on many medically relevant fields.
摘要

项目成果

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{{ truncateString('RUI CHEN', 18)}}的其他基金

Comprehensive Somatic Variant Characterization at the HGSC
HGSC 的综合体细胞变异表征
  • 批准号:
    10662645
  • 财政年份:
    2023
  • 资助金额:
    $ 30.4万
  • 项目类别:
Deep-Learning-Derived Endophenotypes from Retina Images
来自视网膜图像的深度学习衍生的内表型
  • 批准号:
    10706984
  • 财政年份:
    2022
  • 资助金额:
    $ 30.4万
  • 项目类别:
Effects of cornea epithelial barrier disruption on the cornea trigeminal neural circuit
角膜上皮屏障破坏对角膜三叉神经回路的影响
  • 批准号:
    10586519
  • 财政年份:
    2022
  • 资助金额:
    $ 30.4万
  • 项目类别:
Deep-Learning-Derived Endophenotypes from Retina Images
来自视网膜图像的深度学习衍生的内表型
  • 批准号:
    10392211
  • 财政年份:
    2022
  • 资助金额:
    $ 30.4万
  • 项目类别:
Effects of cornea epithelial barrier disruption on the cornea trigeminal neural circuit
角膜上皮屏障破坏对角膜三叉神经回路的影响
  • 批准号:
    10708182
  • 财政年份:
    2022
  • 资助金额:
    $ 30.4万
  • 项目类别:
Modeling Frontotemporal Dementia in Rhesus Macaques
恒河猴额颞叶痴呆模型
  • 批准号:
    10626978
  • 财政年份:
    2019
  • 资助金额:
    $ 30.4万
  • 项目类别:
Modeling Frontotemporal Dementia in Rhesus Macaques
恒河猴额颞叶痴呆模型
  • 批准号:
    10599018
  • 财政年份:
    2019
  • 资助金额:
    $ 30.4万
  • 项目类别:
Modeling Frontotemporal Dementia in Rhesus Macaques
恒河猴额颞叶痴呆模型
  • 批准号:
    9894456
  • 财政年份:
    2019
  • 资助金额:
    $ 30.4万
  • 项目类别:
Modeling Frontotemporal Dementia in Rhesus Macaques
恒河猴额颞叶痴呆模型
  • 批准号:
    10023200
  • 财政年份:
    2019
  • 资助金额:
    $ 30.4万
  • 项目类别:
Novel model systems for the study of cone disorders and other heritable retinal diseases
用于研究视锥细胞疾病和其他遗传性视网膜疾病的新型模型系统
  • 批准号:
    10483221
  • 财政年份:
    2018
  • 资助金额:
    $ 30.4万
  • 项目类别:

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