UCLA Dentist-Scientist and Oral Health-Researcher Training Program

针对PAR-20-056，我们建议重建T90/R90综合机构培训 加州大学洛杉矶分校牙科学院的项目。这个应用程序建立在我们20多年的 加州大学洛杉矶分校的研究培训和职业发展相结合，启动了牙医和科学家的职业生涯 口腔健康-科学家并使他们为应对科学、医疗保健和社会中的不利挑战做好准备。这个 应用程序延续了这一悠久的传统，旨在支持充满活力和多样化的牙科、口腔和 通过严格的跨学科培训计划为受训者提供新颖的头面部研究人员 以及在高度支持的机构环境中的创新研究培训经验。我们有 组建了一支优秀的教师导师团队，他们体现了四个科学优势领域--(1)癌症 生物学，口腔癌与干细胞，(2)颅面生物学，生物工程与再生医学，(3) 微生物-毒力机制和低温电子显微镜的先进成像，以及(4)翻译遗传学， 表观遗传学和基因组学。我们的跨学科培训计划将学员与麻省理工学院的导师联系起来 牙科，医学院，工程学院，琼森综合癌症中心，分子 生物研究所、干细胞研究所和加州纳米系统研究所。这些功能的整合 跨部门中心和研究所提供了丰富的培训环境和巨大的物质资源 和集中化的核心设施。我们提供五个培训途径：(I)牙医-科学家实习生计划(双学位 DDS/PhD)、(2)牙医-博士方案(对牙医进行博士前研究培训)、(3)牙医--科学家 博士后研究员(对牙医的博士后培训)，(4)博士后实习生(口述博士前培训 (V)口腔健康博士后研究员(口腔健康博士后培训)。总而言之，我们的建议 培训计划将培训下一代牙医科学家和口腔健康科学家进行基础， 翻译和临床研究，以改善牙齿、口腔和颅面健康。

In response to PAR-20-056, we propose to reestablish the T90/R90 comprehensive institutional training program at the UCLA School of Dentistry. This application has been built on more than 20 years of our combined research training and career development at UCLA that launched careers of dentist-scientists and oral health-scientists and prepared them for adverse challenges in science, healthcare, and society. The application continues this long-standing tradition and aims to bolster a vigorous and diverse dental, oral and craniofacial research workforce via a rigorous and interdisciplinary training program that offers trainees novel and innovative research training experiences in a highly supportive institutional environment. We have assembled an excellent team of faculty mentors who embody four areas of scientific strengths – (1) Cancer Biology, Oral Cancer & Stem Cells, (2) Craniofacial Biology, Bioengineering & Regenerative Medicine, (3) Microbes – Virulence Mechanisms and Advanced Imaging by CryoEM, and (4) Translational Genetics, Epigenetics, & Genomics. Our interdisciplinary training program links trainees to mentors at the School of Dentistry, School of Medicine, School of Engineering, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, Stem Cell Institute, and California NanoSystem Institute. The integration of these interdepartmental centers and institutes provides a rich training environment with enormous physical resources and centralized core facilities. We offer five training tracks, (i) Dentist-Scientist Trainee Program (dual degree DDS/PhD), (ii) Dentist-PhD Program (predoctoral research training to dentists), (iii) Dentist-Scientists Postdoctoral Fellow (postdoctoral training to dentists), (iv) Predoctoral PhD Trainee (predoctoral training in oral health), and (v) Oral Health Postdoctoral Fellow (postdoctoral training in oral health). Collectively, our proposed training program will train the next generation of dentist-scientists and oral health scientists to conduct basic, translational, and clinical research to improve dental, oral, and craniofacial health.