Efficacy and neural mediators of response to Trauma Management Therapy for PTSD
Efficacy and neural mediators of response to Trauma Management Therapy for PTSD
批准号:
10663775
负责人:
Brooks Casas
金额:
$0.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-07-01 至 2023-06-30
关键词:
AftercareAggressive behaviorAmygdaloid structureAngerAnxietyAttentionBiologicalChronicClinicalCombined Modality TherapyCorpus striatum structureDataDevelopmentEducationEmotionalEnrollmentEnvironmentFrightFunctional Magnetic Resonance ImagingFunctional disorderImageImpairmentIndividualInterpersonal RelationsInterventionLeadMeasuresMediatingMediator of activation proteinPatient Self-ReportPersonsPlayPopulationPost-Traumatic Stress DisordersPrefrontal CortexPreparationPsychotherapyRandomizedRandomized Controlled TrialsRecoveryRecovery of FunctionRehabilitation therapyResearchRoleSocial FunctioningSocial InteractionSocial supportStructureTestingTherapeutic InterventionTraumaTreatment EfficacyVentral StriatumVeteransVietnamWagesWorkanxiety symptomsarmbasecombatcombat veteraneffective therapyefficacy evaluationefficacy testingemotion dysregulationinsightneural correlateneurobehavioralneuroimagingneuromechanismnovelpilot trialpsychoeducationrelating to nervous systemresponsesocialstress related disorder
中文摘要
摘要
愤怒和攻击性是创伤后应激治疗中严重且常见的复杂因素
精神障碍(PTSD)。人际攻击和愤怒与创伤后应激障碍密切相关(Orth&Wiland,
2006年;Taft等人,2012年);ii)与战斗有关的创伤后应激障碍患者特别有害(Novaco&
Chemtob,2002年);和,iii)战斗相关创伤后应激障碍的有效治疗的关键障碍(福布斯等人,2003年;
福布斯等人,2008年)。愤怒和攻击性也会严重损害人的人际关系
退伍军人;这些关系对于恢复功能所需的社会支持是必不可少的
(Beckham等人,1997;Carlson等人,2008;Elbogen等人,2008;Frueh等人,1997;2001;Chemtob等人,
1997年;Freeman&Roca,2001;Gerlock,1994;Glenn等人,2002;Lasko等人,1994;Taft等人,2005,2007 a;
2007年b;Monson&Taft出版社,2005年)。尽管愤怒和攻击性对
患有创伤后应激障碍的退伍军人,尽管愤怒和攻击性对治疗和
康复,对创伤后应激障碍中潜在的人际攻击的神经基础了解很少,或者
促进有愤怒和攻击性困难退伍军人康复的神经机制。
在之前的工作中,我们的团队开发了创伤管理疗法(TMT),这是一种多组分
针对越南时期患有创伤后应激障碍的慢性退伍军人的心理治疗,同时针对恐惧和焦虑症状
如人际功能障碍(Frueh等人,1996;Bedel,Frueh等人,2011)。尽管这种疗法得到了支持
根据在越南时代的慢性退伍军人中进行的一项小型随机对照试验的结果,其疗效尚未在
从OEF/OIF/OND回来的更年轻、不那么慢性的退伍军人。在单独的工作中,我们已经确定
退伍军人的人际攻击、合作和情绪失调机制
与创伤后应激障碍(见初步数据;King-Casas&Chiu,2012;King-Casas等人,2005;朱等人,准备中;
Lindsey等人,2010年)。然而,这些机制在治疗和康复中所起的作用尚不清楚。
在这里,我们建议利用这两条研究路线来(I)评估创伤处理的有效性
TMT治疗OEF/OIF/OND退伍军人创伤后应激障碍
与越战时期患有创伤后应激障碍的退伍军人相比,慢性病程,和(Ii)评估临床神经介质
与TMT相关的改进。
英文摘要
ABSTRACT
Anger and aggression are serious and frequent complicating factors in the treatment of post-traumatic stress
disorder (PTSD). Interpersonal aggression and anger are: i) strongly associated with PTSD (Orth & Wieland,
2006; Taft et al, 2012); ii) particularly pernicious among individuals with combat-related PTSD (Novaco &
Chemtob, 2002); and, iii) critical barriers to effective treatment in combat-related PTSD (Forbes et al., 2003;
Forbes et al., 2008). Anger and aggression can also critically damage the interpersonal relationships of
veterans; these relationships are essential to the social support necessary for recovery of functioning
(Beckham et al., 1997; Carlson et al., 2008; Elbogen et al., 2008; Frueh et al., 1997; 2001; Chemtob et al.,
1997; Freeman & Roca, 2001; Gerlock, 1994; Glenn et al., 2002; Lasko et al., 1994; Taft et al., 2005, 2007a;
2007b; Monson & Taft, 2005). Despite the detrimental impact that anger and aggression have on the lives of
combat veterans with PTSD, and despite the barrier that anger and aggression pose to treatment and
recovery, very little is understood about the neural substrates underlying interpersonal aggression in PTSD, or
the neural mechanisms that promote recovery for veterans with difficulties with anger and aggression.
In previous work, our team has developed Trauma Management Therapy (TMT), a multicomponent
psychotherapy for chronic, Vietnam-era veterans with PTSD targeting both fear and anxiety symptoms, as well
as interpersonal dysfunction (Frueh et al., 1996; Beidel, Frueh et al., 2011). Though this treatment is supported
by results of a small RCT among chronic Vietnam-era veterans, its efficacy has not been evaluated among
younger, less chronic veterans returning from OEF/OIF/OND. In separate work, we have identified
mechanisms of interpersonal aggression, cooperation, and emotional dysregulation in OEF/OIF/OND veterans
with PTSD (see Preliminary Data; King-Casas & Chiu, 2012; King-Casas et al., 2005; Zhu et al., in preparation;
Lindsey et al., 2010). However, the role that these mechanisms play in the treatment and recovery is unknown.
Here, we propose to leverage these two lines of research to (i) evaluate the efficacy of Trauma Management
Therapy (TMT) for the treatment of PTSD in OEF/OIF/OND veterans who are younger and have had a less
chronic course of illness than Vietnam era veterans with PTSD, and (ii) evaluate neural mediators of clinical
improvements associated with TMT.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
Does Validity Measure Response Affect CPT Group Outcomes in Veterans with PTSD?
有效性测量反应是否会影响患有 PTSD 退伍军人的 CPT 小组结果?
DOI:
10.1093/milmed/usz385
发表时间:
2020
期刊:
Military medicine
影响因子:
1.2
作者:
[Williams,MWright, Graham,David, Sciarrino,NicoleA, Estey,Matt, McCurry,KatherineL, Chiu,Pearl, King-Casas,Brooks]
通讯作者:
King-Casas,Brooks
DOI:
10.1002/jclp.23307
发表时间:
2022-07
期刊:
JOURNAL OF CLINICAL PSYCHOLOGY
影响因子:
3
作者:
[Williams, M. Wright, King-Casas, Brooks, Chiu, Pearl H., Sciarrino, Nicole, Estey, Matthew, Hunt, Christopher, McCurry, Katherine, Graham, David P.]
通讯作者:
Graham, David P.
Direct sub-second measurement of neuromodulator signaling during risky decision-making
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批准号:10579985
-
项目类别:
-
资助金额:$65.87万
-
财政年份:2020
-
负责人:Brooks Casas
-
依托单位:
Direct sub-second measurement of neuromodulator signaling during risky decision-making
-
批准号:10377347
-
项目类别:
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资助金额:$65.02万
-
财政年份:2020
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负责人:Brooks Casas
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依托单位:
Neurobehavioral Mechanisms of Social Dysfunction in Borderline Personality Disorder
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批准号:9897363
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项目类别:
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资助金额:$8.41万
-
财政年份:2018
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负责人:Brooks Casas
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依托单位:
Neurobehavioral Mechanisms of Social Dysfunction in Borderline Personality Disorder
-
批准号:10088478
-
项目类别:
-
资助金额:$64.12万
-
财政年份:2018
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负责人:Brooks Casas
-
依托单位:
Neurobehavioral Mechanisms of Social Dysfunction in Borderline Personality Disorder
-
批准号:10319937
-
项目类别:
-
资助金额:$60.98万
-
财政年份:2018
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负责人:Brooks Casas
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依托单位:
Neurobehavioral Mechanisms of Social Dysfunction in Borderline Personality Disorder
-
批准号:9425864
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Neurobehavioral Determinants of Adolescent Substance Use and HIV/STD Behaviors
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Neurobehavioral Determinants of Health Risk Behaviors: From Adolescence to Young Adulthood
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Neurobehavioral Determinants of Adolescent Substance Use and HIV/STD Behaviors
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项目类别:
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资助金额:$68.63万
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财政年份:2013
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负责人:Brooks Casas
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依托单位:
Neurobehavioral Determinants of Health Risk Behaviors: From Adolescence to Young Adulthood
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批准号:10436210
-
项目类别:
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资助金额:$69.11万
-
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-
负责人:Brooks Casas
-
依托单位:
Neurobehavioral Determinants of Adolescent Substance Use and HIV/STD Behaviors
-
批准号:9246477
-
项目类别:
-
资助金额:$66.41万
-
财政年份:2013
-
负责人:Brooks Casas
-
依托单位:
Neurobehavioral Determinants of Adolescent Substance Use and HIV/STD Behaviors
-
批准号:9038349
-
项目类别:
-
资助金额:$67.02万
-
财政年份:2013
-
负责人:Brooks Casas
-
依托单位:
Neurobehavioral Assessment of Interpersonal Functioning in PTSD
-
批准号:7888221
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项目类别:
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资助金额:$0.0万
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财政年份:2009
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负责人:Brooks Casas
-
依托单位:
Neurobehavioral Assessment of Interpersonal Functioning in PTSD
-
批准号:7749838
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项目类别:
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资助金额:$0.0万
-
财政年份:2009
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负责人:Brooks Casas
-
依托单位:
Neurobehavioral Assessment of Interpersonal Functioning in PTSD
-
批准号:8668994
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2009
-
负责人:Brooks Casas
-
依托单位:
Learning Signals Within an Iterated Social Exchange
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批准号:7158475
-
项目类别:
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资助金额:$4.6万
-
财政年份:2006
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负责人:Brooks Casas
-
依托单位:
海外基金