Neurobehavioral Mechanisms of Social Dysfunction in Borderline Personality Disorder

项目概要 边缘性人格障碍（BPD）是一种严重的心理健康状况，会导致严重的心理健康问题。 和身体残疾。边缘性人格障碍临床表现的主要特征包括情感 失调、冲动和不稳定的关系。虽然这些特征在经典中得到了证实 社会关系，BPD 社会决策的神经行为病因学受到的限制 尽管人际关系功能障碍在该疾病的表达中发挥着重要作用，但仍进行了调查。 为了解决这一差距，该提案的总体目标是详细说明行为、计算和神经 BPD 中社会决策中三种候选异常的潜在过程：(i) 风险偏差 做出有关社会伙伴的决定时进行评估； (ii) 对社会预测错误高度敏感 奖励和惩罚； (iii) 与攻击相关的社交学习异常。因此，我们结合得很好—— 从决策神经科学到功能磁共振成像的特色互动游戏 对人际交往的生物学基础形成敏感而具体的神经机械学理解 边缘性 PD 损伤。具体来说，我们在 BPD 中检查：(i) 潜在风险的神经机制 社会和非社会决策的偏好（目标 1）； (ii) 社会的神经机制 奖励/惩罚敏感性（目标 2）； (iii) 导致人际冲动的神经机制 攻击性（目标 3）。

PROJECT SUMMARY Borderline personality disorder (BPD) is a severe mental health condition that confers significant psychological and physical disability. Key features of the clinical presentation of borderline personality disorder include affect dysregulation, impulsivity and unstable relationships. While these features are classically borne out within social relationships, the neurobehavioral etiology of social decision-making in BPD has received limited investigation, despite the prominent role that interpersonal dysfunction plays in the expression of the disorder. To address this gap, the broad goal of this proposal is to detail the behavioral, computational and neural processes underlying three candidate abnormalities in social decision-making within BPD: (i) biases in risk appraisal when making decisions about social partners; (ii) hypersensitivity to prediction errors about social rewards and punishments; and, (iii) aggression-related social learning abnormalities. Thus, we combine well- characterized interactive games from decision neuroscience with functional magnetic resonance imaging to develop a sensitive and specific neuromechanistic understanding of the biological basis of interpersonal impairments in borderline PD. Specifically, we examine in BPD: (i) neural mechanisms underlying risk preferences in social and non-social decision-making (Aim 1); (ii) neural mechanisms of social reward/punishment sensitivity (Aim 2); and (iii) neural mechanisms contributing to impulsive interpersonal aggression (Aim 3).