Neurobehavioral Mechanisms of Social Dysfunction in Borderline Personality Disorder

项目摘要 边缘型人格障碍（BPD）是一种严重的精神健康状况， 和身体残疾。边缘型人格障碍临床表现的主要特征包括情感 失调、冲动和不稳定的关系。虽然这些特点是经典证明了内 社会关系，BPD社会决策的神经行为病因学受到了限制 调查，尽管突出的作用，人际功能障碍发挥的障碍的表达。 为了解决这一差距，该提案的广泛目标是详细说明行为，计算和神经 BPD中社会决策的三个候选异常的潜在过程：（i）风险偏好 评估时作出决定的社会合作伙伴;（ii）超敏反应的预测错误的社会 奖励和惩罚;（iii）与攻击相关的社会学习异常。因此，我们联合收割机结合得很好- 从决策神经科学与功能性磁共振成像的互动游戏， 发展对人际关系的生物学基础的敏感和具体的神经机制理解 边缘性帕金森病具体来说，我们研究BPD：（i）神经机制的风险 偏好在社会和非社会决策（目标1）;（二）神经机制的社会 奖励/惩罚敏感性（目标2）;和（iii）神经机制有助于冲动的人际关系 侵略（目标3）。

PROJECT SUMMARY Borderline personality disorder (BPD) is a severe mental health condition that confers significant psychological and physical disability. Key features of the clinical presentation of borderline personality disorder include affect dysregulation, impulsivity and unstable relationships. While these features are classically borne out within social relationships, the neurobehavioral etiology of social decision-making in BPD has received limited investigation, despite the prominent role that interpersonal dysfunction plays in the expression of the disorder. To address this gap, the broad goal of this proposal is to detail the behavioral, computational and neural processes underlying three candidate abnormalities in social decision-making within BPD: (i) biases in risk appraisal when making decisions about social partners; (ii) hypersensitivity to prediction errors about social rewards and punishments; and, (iii) aggression-related social learning abnormalities. Thus, we combine well- characterized interactive games from decision neuroscience with functional magnetic resonance imaging to develop a sensitive and specific neuromechanistic understanding of the biological basis of interpersonal impairments in borderline PD. Specifically, we examine in BPD: (i) neural mechanisms underlying risk preferences in social and non-social decision-making (Aim 1); (ii) neural mechanisms of social reward/punishment sensitivity (Aim 2); and (iii) neural mechanisms contributing to impulsive interpersonal aggression (Aim 3).