Neurobehavioral Mechanisms of Social Dysfunction in Borderline Personality Disorder
Neurobehavioral Mechanisms of Social Dysfunction in Borderline Personality Disorder
批准号:
10088478
负责人:
Brooks Casas
金额:
$64.12万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-02-01 至 2022-12-31
关键词:
AddressAffectAggressive behaviorBehaviorBehavioralBiologicalBorderline Personality DisorderCharacteristicsClinicalComputer ModelsControl GroupsCorpus striatum structureCost of IllnessDataDecision MakingDiagnosticDiseaseEtiologyEvaluationFeeling suicidalFunctional Magnetic Resonance ImagingFunctional disorderGoalsGrantHumanHypersensitivityImpairmentImpulsivityIndividualInvestigationLateralLeadLearningMental HealthModelingNeurosciencesOutcomeParietal LobeParticipantPlayPrefrontal CortexPrevalenceProcessPunishmentRewardsRiskRisk AssessmentRoleScanningServicesSignal TransductionSocial InteractionSocial outcomeTestingTrustWomanWorkbasebehavioral economicsdesigndisorder controldistrustdyadic interactionemotion dysregulationepidemiologic dataexpectationexperiencehemodynamicsmenneurobehavioralneuroimagingneuromechanismphenomenological modelsphysically handicappedpreferencepsychologicrelating to nervous systemresponsesocialsocial deficitssocial expectationssocial learningsocial relationships
中文摘要
项目摘要
边缘型人格障碍(BPD)是一种严重的精神健康状况,
和身体残疾。边缘型人格障碍临床表现的主要特征包括情感
失调、冲动和不稳定的关系。虽然这些特点是经典证明了内
社会关系,BPD社会决策的神经行为病因学受到了限制
调查,尽管突出的作用,人际功能障碍发挥的障碍的表达。
为了解决这一差距,该提案的广泛目标是详细说明行为,计算和神经
BPD中社会决策的三个候选异常的潜在过程:(i)风险偏好
评估时作出决定的社会合作伙伴;(ii)超敏反应的预测错误的社会
奖励和惩罚;(iii)与攻击相关的社会学习异常。因此,我们联合收割机结合得很好-
从决策神经科学与功能性磁共振成像的互动游戏,
发展对人际关系的生物学基础的敏感和具体的神经机制理解
边缘性帕金森病具体来说,我们研究BPD:(i)神经机制的风险
偏好在社会和非社会决策(目标1);(二)神经机制的社会
奖励/惩罚敏感性(目标2);和(iii)神经机制有助于冲动的人际关系
侵略(目标3)。
英文摘要
PROJECT SUMMARY
Borderline personality disorder (BPD) is a severe mental health condition that confers significant psychological
and physical disability. Key features of the clinical presentation of borderline personality disorder include affect
dysregulation, impulsivity and unstable relationships. While these features are classically borne out within
social relationships, the neurobehavioral etiology of social decision-making in BPD has received limited
investigation, despite the prominent role that interpersonal dysfunction plays in the expression of the disorder.
To address this gap, the broad goal of this proposal is to detail the behavioral, computational and neural
processes underlying three candidate abnormalities in social decision-making within BPD: (i) biases in risk
appraisal when making decisions about social partners; (ii) hypersensitivity to prediction errors about social
rewards and punishments; and, (iii) aggression-related social learning abnormalities. Thus, we combine well-
characterized interactive games from decision neuroscience with functional magnetic resonance imaging to
develop a sensitive and specific neuromechanistic understanding of the biological basis of interpersonal
impairments in borderline PD. Specifically, we examine in BPD: (i) neural mechanisms underlying risk
preferences in social and non-social decision-making (Aim 1); (ii) neural mechanisms of social
reward/punishment sensitivity (Aim 2); and (iii) neural mechanisms contributing to impulsive interpersonal
aggression (Aim 3).
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Direct sub-second measurement of neuromodulator signaling during risky decision-making
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批准号:10579985
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项目类别:
-
资助金额:$65.87万
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财政年份:2020
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负责人:Brooks Casas
-
依托单位:
Direct sub-second measurement of neuromodulator signaling during risky decision-making
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批准号:10377347
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项目类别:
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资助金额:$65.02万
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财政年份:2020
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负责人:Brooks Casas
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依托单位:
Neurobehavioral Mechanisms of Social Dysfunction in Borderline Personality Disorder
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批准号:9897363
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项目类别:
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资助金额:$8.41万
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财政年份:2018
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负责人:Brooks Casas
-
依托单位:
Neurobehavioral Mechanisms of Social Dysfunction in Borderline Personality Disorder
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批准号:10319937
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项目类别:
-
资助金额:$60.98万
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财政年份:2018
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负责人:Brooks Casas
-
依托单位:
Neurobehavioral Mechanisms of Social Dysfunction in Borderline Personality Disorder
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批准号:9425864
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项目类别:
-
资助金额:$63.85万
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财政年份:2018
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负责人:Brooks Casas
-
依托单位:
Efficacy and neural mediators of response to Trauma Management Therapy for PTSD
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批准号:10663775
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项目类别:
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资助金额:$0.0万
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财政年份:2018
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负责人:Brooks Casas
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依托单位:
Neurobehavioral Determinants of Adolescent Substance Use and HIV/STD Behaviors
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批准号:8687637
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项目类别:
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资助金额:$70.84万
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财政年份:2013
-
负责人:Brooks Casas
-
依托单位:
Neurobehavioral Determinants of Adolescent Substance Use and HIV/STD Behaviors
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批准号:8562220
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项目类别:
-
资助金额:$73.12万
-
财政年份:2013
-
负责人:Brooks Casas
-
依托单位:
Neurobehavioral Determinants of Adolescent Substance Use and HIV/STD Behaviors
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批准号:8811110
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项目类别:
-
资助金额:$68.63万
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财政年份:2013
-
负责人:Brooks Casas
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依托单位:
Neurobehavioral Determinants of Health Risk Behaviors: From Adolescence to Young Adulthood
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批准号:10201536
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项目类别:
-
资助金额:$77.1万
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财政年份:2013
-
负责人:Brooks Casas
-
依托单位:
Neurobehavioral Determinants of Health Risk Behaviors: From Adolescence to Young Adulthood
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批准号:10436210
-
项目类别:
-
资助金额:$69.11万
-
财政年份:2013
-
负责人:Brooks Casas
-
依托单位:
Neurobehavioral Determinants of Adolescent Substance Use and HIV/STD Behaviors
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批准号:9246477
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项目类别:
-
资助金额:$66.41万
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财政年份:2013
-
负责人:Brooks Casas
-
依托单位:
Neurobehavioral Determinants of Adolescent Substance Use and HIV/STD Behaviors
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批准号:9038349
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项目类别:
-
资助金额:$67.02万
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财政年份:2013
-
负责人:Brooks Casas
-
依托单位:
Neurobehavioral Assessment of Interpersonal Functioning in PTSD
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批准号:7888221
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项目类别:
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资助金额:$0.0万
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财政年份:2009
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负责人:Brooks Casas
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依托单位:
Neurobehavioral Assessment of Interpersonal Functioning in PTSD
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批准号:7749838
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项目类别:
-
资助金额:$0.0万
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财政年份:2009
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负责人:Brooks Casas
-
依托单位:
Neurobehavioral Assessment of Interpersonal Functioning in PTSD
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批准号:8668994
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项目类别:
-
资助金额:$0.0万
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财政年份:2009
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负责人:Brooks Casas
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依托单位:
Learning Signals Within an Iterated Social Exchange
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批准号:7158475
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项目类别:
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资助金额:$4.6万
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财政年份:2006
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负责人:Brooks Casas
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依托单位:
海外基金