Neurobehavioral Mechanisms of Social Dysfunction in Borderline Personality Disorder

边缘性人格障碍社交功能障碍的神经行为机制

• 批准号: 9897363
• 负责人: Brooks Casas
• 金额: $ 8.41万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9897363
• 关键词: Address; Affect; Aggressive behavior; Behavior; Behavioral; Biological; Borderline Personality Disorder; Characteristics; Clinical; Computer Simulation; Control Groups; Corpus striatum structure; Cost of Illness; Data; Decision Making; Diagnostic; Disease; Etiology; Evaluation; Feeling suicidal; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Grant; Human; Hypersensitivity; Impairment; Impulsivity; Individual; Investigation; Lateral; Lead; Learning; Mental Health; Modeling; Neurosciences; Outcome; Parietal Lobe; Participant; Physically Handicapped; Play; Prefrontal Cortex; Prevalence; Process; Punishment; Rewards; Risk; Risk Assessment; Role; Scanning; Services; Signal Transduction; Social Interaction; Testing; Trust; Woman; Work; base; behavioral economics; design; disorder control; dyadic interaction; emotion dysregulation; epidemiologic data; expectation; experience; hemodynamics; men; neurobehavioral; neuroimaging; neuromechanism; phenomenological models; preference; psychologic; relating to nervous system; response; social; social deficits; social expectations; social learning

PROJECT SUMMARY Borderline personality disorder (BPD) is a severe mental health condition that confers significant psychological and physical disability. Key features of the clinical presentation of borderline personality disorder include affect dysregulation, impulsivity and unstable relationships. While these features are classically borne out within social relationships, the neurobehavioral etiology of social decision-making in BPD has received limited investigation, despite the prominent role that interpersonal dysfunction plays in the expression of the disorder. To address this gap, the broad goal of this proposal is to detail the behavioral, computational and neural processes underlying three candidate abnormalities in social decision-making within BPD: (i) biases in risk appraisal when making decisions about social partners; (ii) hypersensitivity to prediction errors about social rewards and punishments; and, (iii) aggression-related social learning abnormalities. Thus, we combine well- characterized interactive games from decision neuroscience with functional magnetic resonance imaging to develop a sensitive and specific neuromechanistic understanding of the biological basis of interpersonal impairments in borderline PD. Specifically, we examine in BPD: (i) neural mechanisms underlying risk preferences in social and non-social decision-making (Aim 1); (ii) neural mechanisms of social reward/punishment sensitivity (Aim 2); and (iii) neural mechanisms contributing to impulsive interpersonal aggression (Aim 3).

项目总结 摘要边缘型人格障碍(Bpd)是一种严重的心理健康问题。 和身体残疾。边缘型人格障碍临床表现的主要特征包括情感 失调、冲动和不稳定的关系。虽然这些功能在传统上是在 社会关系，BPD的社会决策的神经行为病因学受到的限制 调查，尽管人际功能障碍在精神障碍的表达中起着突出的作用。 为了解决这一差距，这项提案的广泛目标是详细说明行为、计算和神经 BPD内部社会决策中三种候选异常的过程：(I)风险偏向 对社交伙伴做出决定时的评价；(Ii)对社交预测误差的高度敏感 奖励和惩罚；以及，(Iii)与攻击有关的社会学习异常。因此，我们很好地结合了- 描述了从决策神经科学到功能磁共振成像的互动游戏 建立对人际关系生物学基础的敏感而具体的神经机制的理解 临界性帕金森病的损害。具体地说，我们在BPD中研究：(I)潜在风险的神经机制 社会决策和非社会决策中的偏好(目标1)；(2)社会决策的神经机制 奖惩敏感度(目标2)；和(3)促进冲动人际关系的神经机制 攻击性(目标3)。