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Neurobehavioral Mechanisms of Social Dysfunction in Borderline Personality Disorder

边缘性人格障碍社交功能障碍的神经行为机制

基本信息

批准号：
10319937
负责人：
Brooks Casas
金额：
$ 60.98万
依托单位：
VIRGINIA POLYTECHNIC INST AND ST UNIV
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-02-01 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10319937
关键词：
Address Affect Aggressive behavior Behavior Behavioral Biological Borderline Personality Disorder Characteristics Clinical Computer Models Control Groups Corpus striatum structure Cost of Illness Data Decision Making Diagnostic Disease Etiology Evaluation Feeling suicidal Functional Magnetic Resonance Imaging Functional disorder Goals Grant Human Hypersensitivity Impairment Impulsivity Individual Investigation Lateral Lead Learning Mental Health Modeling Neurosciences Outcome Parietal Lobe Participant Persons Play Prefrontal Cortex Prevalence Process Punishment Rewards Risk Risk Assessment Role Scanning Services Signal Transduction Social Interaction Social outcome Testing Trust Woman Work base behavioral economics design disorder control distrust dyadic interaction emotion dysregulation epidemiologic data expectation experience hemodynamics men neurobehavioral neuroimaging neuromechanism phenomenological models physically handicapped preference psychologic relating to nervous system response social social deficits social expectations social learning social relationships

项目摘要

PROJECT SUMMARY Borderline personality disorder (BPD) is a severe mental health condition that confers significant psychological and physical disability. Key features of the clinical presentation of borderline personality disorder include affect dysregulation, impulsivity and unstable relationships. While these features are classically borne out within social relationships, the neurobehavioral etiology of social decision-making in BPD has received limited investigation, despite the prominent role that interpersonal dysfunction plays in the expression of the disorder. To address this gap, the broad goal of this proposal is to detail the behavioral, computational and neural processes underlying three candidate abnormalities in social decision-making within BPD: (i) biases in risk appraisal when making decisions about social partners; (ii) hypersensitivity to prediction errors about social rewards and punishments; and, (iii) aggression-related social learning abnormalities. Thus, we combine well- characterized interactive games from decision neuroscience with functional magnetic resonance imaging to develop a sensitive and specific neuromechanistic understanding of the biological basis of interpersonal impairments in borderline PD. Specifically, we examine in BPD: (i) neural mechanisms underlying risk preferences in social and non-social decision-making (Aim 1); (ii) neural mechanisms of social reward/punishment sensitivity (Aim 2); and (iii) neural mechanisms contributing to impulsive interpersonal aggression (Aim 3).

项目摘要边缘型人格障碍（BPD）是一种严重的精神健康状况，和身体残疾。边缘型人格障碍临床表现的主要特征包括情感失调、冲动和不稳定的关系。虽然这些特点是经典证明了内社会关系，BPD社会决策的神经行为病因学受到了限制调查，尽管突出的作用，人际功能障碍发挥的障碍的表达。为了解决这一差距，该提案的广泛目标是详细说明行为，计算和神经 BPD中社会决策的三个候选异常的潜在过程：（i）风险偏好评估时作出决定的社会合作伙伴;（ii）超敏反应的预测错误的社会奖励和惩罚;（iii）与攻击相关的社会学习异常。因此，我们联合收割机结合得很好- 从决策神经科学与功能性磁共振成像的互动游戏，发展对人际关系的生物学基础的敏感和具体的神经机制理解边缘性帕金森病具体来说，我们研究BPD：（i）神经机制的风险偏好在社会和非社会决策（目标1）;（二）神经机制的社会奖励/惩罚敏感性（目标2）;和（iii）神经机制有助于冲动的人际关系侵略（目标3）。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Reinforcement Learning Disruptions in Individuals With Depression and Sensitivity to Symptom Change Following Cognitive Behavioral Therapy.

认知行为治疗后抑郁症和对症状变化敏感的个体的强化学习中断。

DOI：
10.1001/jamapsychiatry.2021.1844
发表时间：
2021-10-01
期刊：
JAMA psychiatry
影响因子：
25.8
作者：
Brown VM;Zhu L;Solway A;Wang JM;McCurry KL;King-Casas B;Chiu PH
通讯作者：
Chiu PH

Valuation of peers' safe choices is associated with substance-naïveté in adolescents.

DOI：
10.1073/pnas.1919111117
发表时间：
2020-12-15
期刊：
Proceedings of the National Academy of Sciences of the United States of America
影响因子：
11.1
作者：
Chung D;Orloff MA;Lauharatanahirun N;Chiu PH;King-Casas B
通讯作者：
King-Casas B

Impaired mentalizing in depression and the effects of borderline personality disorder on this relationship.

DOI：
10.1186/s40479-021-00153-x
发表时间：
2021-05-04
期刊：
Borderline personality disorder and emotion dysregulation
影响因子：
4.1
作者：
Rifkin-Zybutz RP;Moran P;Nolte T;Feigenbaum J;King-Casas B;London Personality and Mood Disorder Consortium;Fonagy P;Montague RP
通讯作者：
Montague RP