Multidisciplinary Training in Environmental Toxicology

环境毒理学多学科培训

• 批准号: 10659034
• 负责人: JOHN J LAPRES
• 金额: $ 48.98万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10659034
• 关键词: Training; environmental toxicology; multidisciplinary

PROJECT SUMMARY/ABSTRACT The multidisciplinary Environmental and Integrative Toxicological Sciences (EITS) Training Program at Michigan State University (MSU) produces scientists with a base knowledge in environmental toxicology coupled with research in a biomedical basic science graduate program. Predoctoral trainees must meet the full PhD requirements of their partnering biomedical doctoral program and complete the coursework, research and interactive aspects of the EITS Doctoral Program administered through the Institute for Integrative Toxicology (IIT). The dual nature of the training is recognized in the biomedical science-environmental toxicology title of the degree awarded (e.g., PhD in “Biochemistry and Molecular Biology-Environmental Toxicology”). Graduates of the program are well equipped to become leaders in their respective fields and conduct research capable of addressing complex environmental toxicological problems that require collaborative, multidisciplinary approaches. Twenty-five training faculty conduct predoctoral training in nine basic science PhD programs (Biochemistry and Molecular Biology, Cell and Molecular Biology, Comparative Medicine and Integrative Biology, Food Science and Human Nutrition, Genetics, Microbiology and Molecular Genetics, Neuroscience, Pharmacology and Toxicology, and Physiology). Added to the basic biomedical science-based education and environmental toxicology research training are didactic, toxicology-oriented courses and other requirements of the EITS Program. This coursework, career development opportunities and multidisciplinary activities provided by the IIT impart a wider scope of knowledge than is available within basic science programs alone. Research topics for trainees span various organ systems and encompass gene-environment interactions and the role of environmental stressors in disease susceptibility and progression. Integrative biology is central to the research training, which emphasizes whole animal, cell-based, molecular and various “omic” methodologies to understand adverse outcomes and mechanisms of toxicity in a collaborative atmosphere. The postdoctoral training program involves not only conducting research in the laboratories of the training faculty but also gaining additional environmental toxicology experience and career-building opportunities by following an individual development plan (IDP). In addition, participation in IIT and University-wide activities is also encouraged to broaden the training experience. This application requests support of seven predoctoral and two postdoctoral trainees, thereby continuing a highly effective multidisciplinary and interactive training program that combines formal and informal approaches to prepare graduates for leadership roles in research that aims to advance our understanding of adverse outcomes from exposure to environmental chemicals.

项目总结/摘要 密歇根州的多学科环境和综合毒理学科学培训计划 州立大学（MSU）培养具有环境毒理学基础知识的科学家， 生物医学基础科学研究生课程。博士前学员必须满足完整的博士学位 他们的合作生物医学博士课程的要求，并完成课程，研究和 通过综合毒理学研究所管理的EITS博士课程的互动方面 （IIT）。培训的双重性质是公认的生物医学科学-环境毒理学标题的 授予的学位（例如，生物化学和分子生物学-环境毒理学博士）。毕业生 该计划完全有能力成为各自领域的领导者，并进行能够 解决复杂的环境毒理学问题， 接近。25个培训教师在9个基础科学博士课程中进行博士前培训 （生物化学与分子生物学，细胞与分子生物学，比较医学与综合生物学， 食品科学与人类营养学，遗传学，微生物学与分子遗传学，神经科学，药理学 毒理学和生理学）。增加了以生物医学科学为基础的教育和环境 毒理学研究培训是教学性的、面向毒理学的课程，以及EITS的其他要求 程序.该课程，职业发展机会和IIT提供的多学科活动 传授比基础科学课程更广泛的知识。研究课题 受训者跨越各种器官系统，包括基因-环境相互作用和 环境压力因素对疾病易感性和进展的影响。综合生物学是这项研究的核心 培训，强调整个动物，细胞为基础的，分子和各种“组学”的方法来了解 在合作的气氛中的不良后果和毒性机制。博士后培养计划 不仅涉及在培训学院的实验室进行研究， 环境毒理学经验和职业发展机会，通过以下个人发展 计划（IDP）。此外，还鼓励参与IIT和全校活动，以扩大 培训经验。本申请要求七名博士前和两名博士后学员的支持， 从而继续一个高效的多学科和互动的培训计划，结合正式和 非正式的方法来准备毕业生在研究中的领导作用，旨在促进我们的 了解接触环境化学品的不良后果。

项目成果

Ovarian volume partially explains associations of phthalate biomarkers with anti-Müllerian hormone and estradiol in midlife women.

• DOI: 10.1016/j.envint.2023.107771
• 发表时间: 2023-02
• 期刊: ENVIRONMENT INTERNATIONAL
• 影响因子: 11.8
• 作者: Cinzori, Maria E.;Pacyga, Diana C.;Babayev, Elnur;Duncan, Francesca E.;Li, Zhong;Williams, Paige L.;Flaws, Jodi A.;Strakovsky, Rita S.
• 通讯作者: Strakovsky, Rita S.

Determinants of urinary phthalate biomarker concentrations in pre- and perimenopausal women with consideration of race.

考虑种族的绝经前和围绝经期妇女尿邻苯二甲酸盐生物标志物浓度的决定因素。

• DOI: 10.1016/j.envres.2022.114056
• 发表时间: 2022
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: Ryva,BradA;Haggerty,DianaK;Pacyga,DianaC;James-Todd,Tamarra;Li,Zhong;Flaws,JodiA;Strakovsky,RitaS
• 通讯作者: Strakovsky,RitaS

Inhalation of cigarette smoke induces regions of altered DNA methylation (RAMs) in SENCAR mouse lung.

吸入香烟烟雾会诱导 SENCAR 小鼠肺部 DNA 甲基化 (RAM) 区域发生改变。

• DOI: 10.1016/j.tox.2009.03.001
• 发表时间: 2009
• 期刊: Toxicology
• 影响因子: 4.5
• 作者: Phillips,JenniferM;Goodman,JayI
• 通讯作者: Goodman,JayI

Dietary Docosahexaenoic Acid Prevents Silica-Induced Development of Pulmonary Ectopic Germinal Centers and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse.

• DOI: 10.3389/fimmu.2018.02002
• 发表时间: 2018
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Bates MA;Akbari P;Gilley KN;Wagner JG;Li N;Kopec AK;Wierenga KA;Jackson-Humbles D;Brandenberger C;Holian A;Benninghoff AD;Harkema JR;Pestka JJ
• 通讯作者: Pestka JJ

Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration.

• DOI: 10.3390/nu12113523
• 发表时间: 2020-11-16
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Sarparast M;Dattmore D;Alan J;Lee KSS
• 通讯作者: Lee KSS