Neurobiology Summer Course

神经生物学暑期课程

• 批准号: 10670045
• 负责人: Linda E Hyman
• 金额: $ 26.8万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670045
• 关键词: Address; Area; Biological; Biological Models; Clinical; Creativeness; Data; Data Analyses; Data Set; Education; Educational process of instructing; Electrophysiology (science); Equipment; Experimental Designs; Faculty; Funding; Future; Genetic; Goals; Grant; Health; Hour; Image; Instruction; International; Knowledge; Laboratories; Lead; Learning; Mentors; Mentorship; Methodology; Modernization; Molecular; Names; National Institute of Neurological Disorders and Stroke; Nervous System; Nervous System Physiology; Neurobiology; Neurological Models; Neurons; Neurosciences; Occupations; Participant; Peer Review; Postdoctoral Fellow; Professional Competence; Ramp; Research; Research Personnel; Research Project Grants; Running; Scientist; Side; Structure; Students; Technical Expertise; Techniques; Technology; Training; Training Programs; United States National Institutes of Health; Work; Writing; design; empowerment; experience; experimental study; functional genomics; graduate student; grasp; hands on instruction; innovation; lectures; marine; member; multidisciplinary; nervous system disorder; neural; peer; peer networks; pre-doctoral; programs; skills; statistics; technology platform; unconscious bias

The goal of “Neurobiology: Mechanisms & Advanced Approaches” (aka the Neurobiology course) at the Marine Biological Laboratory (MBL) in Woods Hole, MA is to augment conventional training of participants with intensive and immersive training in neurobiology with a particular focus on cellular and molecular mechanisms that govern nervous system function in health and neurological disorders. This program is a comprehensive, research-oriented course that runs for eight weeks, from the mid-June to early August and it is targeted to pre- and post-doctoral trainees as well as early-stage faculty members transitioning into neuroscience. A hallmark of this course is the opportunity to work side-by-side with internationally recognized experts using state-of-the- art technologies. The goal is to empower participants to approach neuroscientific inquiry using the most advanced and appropriate technologies available. A new and unique aspect of the course is the focus on how genetic or environmental perturbations lead to neurological disorders. With a faculty to participant ratio of ≥1:1, participants benefit from ~450 hours of intensive, hands-on instruction in three key areas of modern neurobiology: Functional Genomics, Electrophysiology & Neural Excitability, and Imaging Neuronal Structure & Function. Participants gain practical experience in scientific rigor by designing and executing experiments in team-based research projects. They also receive hands-on training in quantitative data analysis, appropriate statistics, and preparing figures that transparently display their results. Finally, participants learn to avoid unconscious bias and common pitfalls encountered with advanced technologies and how to critically evaluate data. The specific aims of the course are: 1) To introduce students to a breadth of foundational and emerging concepts governing the nervous system in health and neurological disorders; 2) To provide hands-on, multidisciplinary training in advanced techniques for analyzing neuronal structure and function; 3) To impart an understanding of rigorous experimental design and quantitative analysis of neuroscience datasets; 4) To promote independence through building professional skills and a broad mentorship network. Upon course completion, participants will be transformed into rigorous, fearless, and creative scientists, firmly committed to the strategic goals of NINDS, and poised to become the leaders of the future.

马萨诸塞州伍兹霍尔海洋生物实验室 (MBL) 的“神经生物学：机制与高级方法”（又名神经生物学课程）的目标是通过神经生物学强化和沉浸式培训来增强参与者的传统培训，特别关注控制健康和神经系统疾病中神经系统功能的细胞和分子机制。该项目是一门以研究为导向的综合性课程，从六月中旬到八月初持续八周，针对的是博士前和博士后学员以及过渡到神经科学领域的早期教员。本课程的一个特点是有机会使用最先进的技术与国际公认的专家并肩工作。目标是使参与者能够使用最先进、最合适的技术进行神经科学研究。该课程的一个新颖且独特的方面是重点关注遗传或环境扰动如何导致神经系统疾病。教师与参与者的比例≥1:1，参与者受益于现代神经生物学三个关键领域约 450 小时的密集实践教学：功能基因组学、电生理学和神经兴奋性以及神经元结构和功能成像。参与者通过在团队研究项目中设计和执行实验来获得科学严谨性的实践经验。他们还接受定量数据分析、适当统计以及准备透明显示结果的图表方面的实践培训。最后，参与者学习避免无意识的偏见和先进技术遇到的常见陷阱以及如何批判性地评估数据。本课程的具体目标是： 1) 向学生介绍控制健康和神经系统疾病的神经系统的广泛基础和新兴概念； 2) 提供分析神经元结构和功能的先进技术的实践、多学科培训； 3）传授对神经科学数据集的严格实验设计和定量分析的理解； 4) 通过培养专业技能和广泛的指导网络来促进独立性。课程完成后，学员将转变为严谨、无畏、富有创造力的科学家，坚定致力于NINDS的战略目标，并准备成为未来的领导者。

项目成果

HTR7 Mediates Serotonergic Acute and Chronic Itch.

HTR7 介导血清素能急性和慢性瘙痒

• DOI: 10.1016/j.neuron.2015.05.044
• 发表时间: 2015-07-01
• 期刊: Neuron
• 影响因子: 16.2
• 作者: Morita T;McClain SP;Batia LM;Pellegrino M;Wilson SR;Kienzler MA;Lyman K;Olsen AS;Wong JF;Stucky CL;Brem RB;Bautista DM
• 通讯作者: Bautista DM

Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells.

化学选择性狼蛛毒素报告活细胞中野生型离子通道的电压激活。

• DOI: 10.1073/pnas.1406876111
• 发表时间: 2014
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Tilley,DrewC;Eum,KennethS;Fletcher-Taylor,Sebastian;Austin,DanielC;Dupré,Christophe;Patrón,LilianA;Garcia,RitaL;Lam,Kit;Yarov-Yarovoy,Vladimir;Cohen,BruceE;Sack,JonT
• 通讯作者: Sack,JonT

Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses.

• DOI: 10.1038/s41467-021-21004-x
• 发表时间: 2021-01-29
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Li S;Raychaudhuri S;Lee SA;Brockmann MM;Wang J;Kusick G;Prater C;Syed S;Falahati H;Ramos R;Bartol TM;Hosy E;Watanabe S
• 通讯作者: Watanabe S