UTMB OAIC Metabolism and Biology Resource Core 1 (MBRC1)

项目总结/摘要（MBRC 1） UTMB OAIC代谢和生物学资源核心（MBRC 1）促进和支持基础科学， 与OAIC主题相关的翻译研究，该主题是将功能丧失和获得的途径翻译为 干预措施，以优化不同老年人群的功能恢复。MBRC 1对于 UTMB OAIC的成功，支持了许多关于肌肉老化机制的关键发现 和肌肉减少症。在本周期中，它支持了21项NIH赠款，11项其他外部赠款和12项OAIC 项目 MBRC 1的具体目标是： 1.提供分析支持，并增加OAIC研究的价值。 2.开发新的方法来研究功能丧失和恢复的机制。 3.对早期研究人员进行基础科学分析和方法方面的培训， 对老年人功能丧失、获得和恢复的转化研究。 MBRC 1支持对肌肉减少症，身体功能障碍和恢复需要的基础和转化研究 代谢表型分析、分子生物学技术、示踪方法、动物模型和细胞培养。它 提供了必要的工具，以确定发生在全身，组织和细胞的动态变化， 老年人的水平;量化年龄，疾病，不活动和合成代谢干预的代谢影响; 并确定这些变化背后的基本机制。MBRC 1还促进了 分子、细胞和示踪方法在动物和人类的个体实验中发现 老年人特定病理生理反应的机制。它还发展到 支持翻译的下一步-大型临床试验-通过开发样本生物库和服务 加工和运输。 在下一个周期，MBRC 1将扩大分子代谢资源并支持反向翻译 通过进一步开发和利用可诱导的肌肉特异性基因敲除小鼠模型， 示踪方法，开发用于肌肉减少症的新疗法，并提供机构 代谢组学和转录组学资源提供给OAIC研究者。它还将继续提供资源， 早期调查员和OAIC试点研究，协助生成和利用初步数据 竞争性的补助金申请。

PROJECT SUMMARY/ABSTRACT (MBRC1) The UTMB OAIC Metabolism and Biology Resource Core (MBRC1) promotes and supports basic science and translational research relevant to the OAIC theme which is Translate pathways of functional loss and gain into interventions to optimize functional recovery in diverse geriatric populations. The MBRC1 has been critical to the success of the UTMB OAIC, having supported many key discoveries on the mechanisms of muscle aging and sarcopenia. In the current cycle, it has supported 21 NIH grants, 11 other external grants, and 12 OAIC projects. The MBRC1 specific aims are: 1. Provide analytical support and add value to OAIC research. 2. Develop new methods to study the mechanisms of functional loss and recovery. 3. Train early-stage investigators on the analytical and methodological aspects of basic science and translational research on functional loss, gain and recovery in older adults. MBRC1 supports basic and translational research on sarcopenia, physical dysfunction and recovery requiring metabolic phenotyping, molecular biology techniques, tracer methodologies, animal models and cell cultures. It provides essential tools to determine the dynamic changes that occur at the whole-body, tissue and cellular levels in older individuals; quantify the metabolic effects of age, disease, inactivity and anabolic interventions; and determine the basic mechanisms that underlie these changes. MBRC1 also promotes integration of molecular, cellular and tracer methodologies within individual experiments in animals and humans to discover the mechanisms that underlie specific pathophysiological responses in older adults. It has also evolved to support the next step in translation – large clinical trials – by developing a biobank and services for sample processing and shipping. Over the next cycle, MBRC1 will expand the molecular metabolism resources and support reverse translation by further developing and utilizing inducible muscle specific knockout mouse models, integrating the use of traceromic methods, developing novel therapeutics for sarcopenia, and providing access to institutional metabolomic and transcriptomic resources to OAIC investigators. It will also continue to provide resources for early-stage investigators and OAIC pilot studies, assisting in the generation and utilization of preliminary data for competitive grant applications.