Bioactive Lipid Mediators Core (BLMC)

生物活性脂质介质核心 (BLMC)

基本信息

  • 批准号:
    10713092
  • 负责人:
  • 金额:
    $ 48.7万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-08-15 至 2028-06-30
  • 项目状态:
    未结题

项目摘要

The Bioactive Lipid Mediators Core (BLMC) is designed to support the ongoing work of affiliated scientists aiming to understand the systemic and neurophysiological outcomes of chronic drug use on lipid signaling. The focus on lipid biomarkers targets an emerging field that has unique promise to add a novel framework for understanding how lipid signaling in a wide range of tissues (e.g., plasma, CNS, liver, breast milk) is related to homeostatic dysregulation associated with the development and maintenance of drug use disorders. The Bradshaw lab has developed lipid extraction and analytical techniques aimed specifically at small molecule lipid metabolites like the endocannabinoids, lipoamines, prostaglandins, leukotrienes, and resolvins. These classes of lipids of have been shown to change in response to exposure to drugs of abuse and understanding this regulation has the potential to provide unique insight into how both acute and chronic drug use drives both systemic and central nervous system changes. This understanding would then drive the discovery of novel therapies to treat drug addiction. We will accomplish this by 1) Evaluation of plasma lipidomics patterns in multiple drug abuse models. Using animal models of drug use (THC, opioids, alcohol) we will use our optimized analytical techniques for analysis of bioactive lipid metabolite signaling molecules in plasma to determine how acute and chronic drug exposure causes systemic changes in these lipid classes. This analysis technique will then be used to determine how endogenous cannabinoid and related lipid signaling molecules changes in different disease states (PTSD, concussion, drug addiction) in human plasma. 2) Analyze sex difference in bioactive lipids in in targeted areas of the CNS with chronic drug use as a function of genetic sex. This will provide a novel framework to evaluate unique characteristics across and between drug models and sex. 3) Identification of changes in bioactive lipids in breast milk with exposure to drugs of abuse (THC, opioids). Lipidomics analysis of breastmilk in rodent models of drug use (THC, opioids) will provide a clearer understanding on how the presence of these drugs changes the lipid profile of breastmilk in a way that may have long term health consequences for offspring. 4) Develop data science analytical techniques of bioactive lipid metabolites to drive novel hypotheses on how drugs of abuse cause changes in systemic and CNS lipid signaling. Coupling the power of increasingly powerful analytical techniques with novel data mining and cluster analyses developed in-house will provide the field with new tools for interpreting lipid metabolomic information. 5) Increase the pipeline for underrepresented minority (URM) students for careers in STEM with a focus on lipidomic mass spectrometric techniques. In partnership with minority serving programs at IU, URM students will be provided unique opportunities for training and research that are tailored to the field of lipidomics and mass spectrometry as well as multiple programmatic opportunities for professional development.
生物活性脂质介质核心(BLMC)旨在支持附属科学家正在进行的工作

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Heather Bryte Bradshaw其他文献

Heather Bryte Bradshaw的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Heather Bryte Bradshaw', 18)}}的其他基金

Annual Cannabinoid Research Society Symposium on the Cannabinoids
年度大麻素研究会大麻素研讨会
  • 批准号:
    10672437
  • 财政年份:
    2021
  • 资助金额:
    $ 48.7万
  • 项目类别:
Annual Cannabinoid Research Society Symposium on the Cannabinoids
年度大麻素研究会大麻素研讨会
  • 批准号:
    10461950
  • 财政年份:
    2021
  • 资助金额:
    $ 48.7万
  • 项目类别:
Microglial activation by N-arachidonoyl glycine
N-花生四烯酰甘氨酸激活小胶质细胞
  • 批准号:
    8190925
  • 财政年份:
    2011
  • 资助金额:
    $ 48.7万
  • 项目类别:
Microglial activation by N-arachidonoyl glycine
N-花生四烯酰甘氨酸激活小胶质细胞
  • 批准号:
    8306754
  • 财政年份:
    2011
  • 资助金额:
    $ 48.7万
  • 项目类别:
Endocannabinoids and Reproductive Pain
内源性大麻素和生殖疼痛
  • 批准号:
    6691102
  • 财政年份:
    2003
  • 资助金额:
    $ 48.7万
  • 项目类别:
Endocannabinoids and Reproductive Pain
内源性大麻素和生殖疼痛
  • 批准号:
    6805720
  • 财政年份:
    2003
  • 资助金额:
    $ 48.7万
  • 项目类别:
Endocannabinoids and Reproductive Pain
内源性大麻素和生殖疼痛
  • 批准号:
    6949950
  • 财政年份:
    2003
  • 资助金额:
    $ 48.7万
  • 项目类别:

相似海外基金

Collaborative Research: Overlooked Oxidation of Aqueous Alcohols: Kinetics, Mechanism, and Relevance to Water Reuse
合作研究:被忽视的水醇氧化:动力学、机制以及与水回用的相关性
  • 批准号:
    2304861
  • 财政年份:
    2023
  • 资助金额:
    $ 48.7万
  • 项目类别:
    Continuing Grant
STTR Phase I: Development of Modular Reactors to Convert Methane to Alcohols at Low Temperatures
STTR 第一阶段:开发在低温下将甲烷转化为醇的模块化反应器
  • 批准号:
    2151256
  • 财政年份:
    2023
  • 资助金额:
    $ 48.7万
  • 项目类别:
    Standard Grant
Development of amine-dehydrogenase and lyase biocatalysts for the sustainable manufacturing of unnatural chiral amino acids and amino alcohols
开发胺脱氢酶和裂解酶生物催化剂,用于可持续生产非天然手性氨基酸和氨基醇
  • 批准号:
    2870226
  • 财政年份:
    2023
  • 资助金额:
    $ 48.7万
  • 项目类别:
    Studentship
Collaborative Research: Overlooked Oxidation of Aqueous Alcohols: Kinetics, Mechanism, and Relevance to Water Reuse
合作研究:被忽视的水醇氧化:动力学、机制以及与水回用的相关性
  • 批准号:
    2304860
  • 财政年份:
    2023
  • 资助金额:
    $ 48.7万
  • 项目类别:
    Continuing Grant
Postdoctoral Fellowship: MPS-Ascend: Development of Selective Reaction Schemes for Photoactivation of Alcohols
博士后奖学金:MPS-Ascend:醇光活化选择性反应方案的开发
  • 批准号:
    2316541
  • 财政年份:
    2023
  • 资助金额:
    $ 48.7万
  • 项目类别:
    Fellowship Award
Development of phosphorylation of alcohols in protein based on the structural modification of phosphoenolpyruvate
基于磷酸烯醇丙酮酸结构修饰的蛋白质醇磷酸化研究进展
  • 批准号:
    22KJ1152
  • 财政年份:
    2023
  • 资助金额:
    $ 48.7万
  • 项目类别:
    Grant-in-Aid for JSPS Fellows
Nickel Cross-Coupling Cascades with α-Heteroatom Radicals to Prepare Sterically Hindered Alcohols and Amines
镍与α-杂原子自由基交叉偶联级联制备位阻醇和胺
  • 批准号:
    10604535
  • 财政年份:
    2023
  • 资助金额:
    $ 48.7万
  • 项目类别:
Towards a better understanding of the effect of the pentafluorosulfanyl group on the lipophilicity and acid/base properties of alcohols and amines
更好地了解五氟硫基对醇和胺的亲脂性和酸/碱性质的影响
  • 批准号:
    571856-2021
  • 财政年份:
    2022
  • 资助金额:
    $ 48.7万
  • 项目类别:
    Alliance Grants
Pd-Catalyzed C(sp3)-H Functionalizations Directed by Free Alcohols and Boc-Protected Amines
由游离醇和 Boc 保护的胺引导的 Pd 催化 C(sp3)-H 官能化
  • 批准号:
    10606508
  • 财政年份:
    2022
  • 资助金额:
    $ 48.7万
  • 项目类别:
MPS-Ascend: Nickel/Photoredox-Catalyzed C(sp3)–C(sp3) Cross-Coupling Between Alkyl Halides and Activated Alcohols
MPS-Ascend:镍/光氧化还原催化的 C(sp3)→C(sp3) 烷基卤化物和活化醇之间的交叉偶联
  • 批准号:
    2213210
  • 财政年份:
    2022
  • 资助金额:
    $ 48.7万
  • 项目类别:
    Fellowship Award
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了