Leadership & Administration Core

科罗拉多性别差异和女性健康卓越研究专门中心（SCORE） 主要研究性腺功能丧失的生物能量和心脏代谢后果。的 SCORE的首要科学目标是解决性腺衰老对人类生殖系统的影响方面的知识空白。 能量稳态和代谢的调节，通过进行机械驱动的研究， 基础到临床的转化谱。科罗拉多评分关注的是 腹部脂肪堆积和相关的心脏代谢功能障碍，这是由于缺乏 卵巢功能首要的教育目标是让新的研究人员参与研究， 通过指导和培训活动，加强职业发展。的 领导行政核心（LAC）提供基础设施支持，确保科学和 教育目标可以实现。拉丁美洲和加勒比地区的主要目标：1）为一个翻译性的 和跨学科的研究计划集中在性腺功能丧失的后果， 增加与年龄有关的疾病的风险; 2）评估SCORE研究的进展和生产力 项目，并在必要时就资源的重新分配作出决定; 3）促进 SCORE研究项目，试点项目，SCORE学者，教师和工作人员，4）促进一代 通过职业生涯与SCORE的重点相关的新的翻译研究机会 加强核心奖（CEC），并通过与其他SCORE合作; 5）整合 SCORE与科罗拉多大学安舒茨医学院的中心和项目密切合作 （CU-AMC），包括老龄化多学科中心（MCoA），卢德曼家庭妇女中心 健康研究（CWHR），科罗拉多临床和转化科学研究所（CCTSI），营养肥胖 研究中心（NORC），和多个机构的培训赠款; 6）提供统计，数据管理， 和评估支持SCORE研究项目和试点项目;和7）提供行政 支持所有SCORE的财务监督、监管监督、调度和一般管理 活动为了有效地实现这些目标，法律援助委员会将包括一名主任、副主任、8- 执行委员会成员，内部咨询委员会（IAB）3名成员，外部咨询委员会3名成员 (EAB)和LAC支持人员。SCORE的研究人员和顾问具有互补的优势， 提升SCORE在当地和全国的影响力。他们是著名的科学家， 跨学科和翻译研究与SCORE的重点一致，他们拥有领导地位 在具有重要战略意义的委员会、董事会、中心和培训赠款中的职位，使他们能够 促进SCORE合作。科罗拉多SCORE团队处于非常有利的位置， 研究影响妇女健康的性别差异。

The Colorado Specialized Center of Research Excellence (SCORE) on Sex Differences and Women’s Health is focused on Bioenergetic and Cardiometabolic Consequences of the Loss of Gonadal Function. The overarching scientific goal of the SCORE is to address gaps in knowledge of the impact of gonadal aging on the regulation of energy homeostasis and metabolism by conducting mechanistically driven research across the basic-to-clinical translational spectrum. The Colorado SCORE is focused on the increased propensity for abdominal fat accumulation and the associated cardiometabolic dysfunction that are consequent to the loss of ovarian function. The overarching educational goal is to engage new investigators in research aligned with the focus of the SCORE through mentoring and training activities to enhance career development. The Leadership Administrative Core (LAC) provides infrastructural support that ensures the scientific and educational goals can be achieved. Major LAC objectives: 1) provide scientific leadership for a translational and transdisciplinary research program focused on the consequences of the loss of gonadal function that increase risk for age-related diseases; 2) evaluate the progress and productivity of the SCORE Research Projects and, if necessary, make decisions about the reallocation of resources; 3) foster collaboration among the SCORE Research Projects, Pilot Projects, SCORE Scholars, faculty, and staff, 4) promote the generation of new translational research opportunities related to the focus of the SCORE through the Career Enhancement Core (CEC) awards and through collaborations with other SCOREs; 5) integrate activities of the SCORE with closely aligned Centers and Programs at the University of Colorado Anschutz Medical Campus (CU-AMC), including the Multidisciplinary Center on Aging (MCoA), Ludeman Family Center for Women’s Health Research (CWHR), Colorado Clinical and Translational Sciences Institute (CCTSI), Nutrition Obesity Research Center (NORC), and multiple institutional training grants; 6) provide statistical, data management, and evaluation support for the SCORE Research Projects and Pilot Projects; and 7) provide administrative support for financial oversight, regulatory oversight, and scheduling and general management of all SCORE activities. To carry out these objectives effectively, the LAC will include a Director, Associate Director, 8- member Executive Committee, 3-member Internal Advisory Board (IAB), 3-member External Advisory Board (EAB), and LAC support staff. The SCORE investigators and advisors have complementary strengths that elevate the impact of the SCORE both locally and nationally. They are renowned scientists with experience in interdisciplinary and translational research aligned with the focus of the SCORE, and they hold leadership positions on strategically important committees, boards, centers, and training grants that enable them to catalyze SCORE collaborations. The Colorado SCORE team is exceptionally well-positioned to advance research on sex differences that impact women’s health.