Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center

身体活动联盟分子传感器 - 科罗拉多临床中心

• 批准号: 10320753
• 负责人: Wendy M Kohrt
• 金额: $ 251.75万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-06 至 2023-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10320753
• 关键词: Acute; Address; Adult; Advisory Committees; Age; American; Animals; Bioinformatics; Biological Markers; Biomedical Research; Biopsy; Blood specimen; Chemicals; Chronic; Chronic Disease; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Collection; Colorado; Common Data Element; Complex; Control Groups; Cytomegalovirus Infections; Data Analyses; Disease; Doctor of Philosophy; Eligibility Determination; Enrollment; Ensure; Exercise; Faculty; Foundations; Future; Goals; Guidelines; Health; Health Benefit; Hospitals; Human; Individual; Information Dissemination; Institution; Institutional Review Boards; Intervention; Intervention Trial; Investigation; Knowledge; Lead; Longevity; Manuals; Manuscripts; Maps; Medical; Medicine; Metabolic; Molecular; Monitor; Participant; Phase; Phenotype; Physical activity; Physiological; Physiology; Population; Preparation; Prevention; Primary Prevention; Procedures; Protocols documentation; Publications; Reporting; Research; Research Activity; Research Personnel; Research Support; Resistance; Resources; Review Committee; Safety; Sample Size; Sampling; Science; Services; Signal Pathway; Signal Transduction; Site; System; Testing; Therapeutic Intervention; TimeLine; Tissue Sample; Tissues; Training; Transducers; Translational Research; Universities; animal data; clinical center; cohort; data management; data quality; data sharing; exercise intervention; experience; fitness; human data; improved; interest; meetings; metabolic phenotype; operation; preventive intervention; quality assurance; recruit; response; screening; success; symposium

Physical activity (PA) has numerous and profound benefits on health and function, yet there is limited knowledge of the mechanistic signals that underlie these benefits. Such knowledge is critical for optimizing the effective use of PA as a preventive or therapeutic intervention strategy for specific diseases and in specific populations. The overarching goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to address this knowledge gap by characterizing the molecular responses to PA. This will be accomplished through the collection of blood and tissue samples from both humans and animals, which will then be subjected to extensive “Omics” analyses. By generating a comprehensive map of molecular responses to PA, MoTrPAC will lay the foundation for a new era of biomedical research on Precision Exercise Medicine. The University of Colorado Anschutz Medical Campus (CU-AMC) is exceptionally well poised to lead a MoTrPAC Adult Clinical Center and to contribute to all Consortium activities. Our investigators and collaborators have extensive experience with complex clinical PA intervention trials, including tissue sampling, in cohorts spanning the entire adult age spectrum. Our expertise extends across multiple physiological systems, diseases, and health conditions, and includes broad proficiency in physiologic, metabolic, and morphometric phenotyping. The facilities at CU-AMC for MoTrPAC activities are outstanding. The proposed MoTrPAC – Colorado Clinical Center will accomplish the following Specific Aims (SA): SA1: Contribute to, and lead when appropriate, all MoTrPAC Phase 1 planning activities (Year 1) described in RFA-RM-15-015 through participation on the MoTrPAC Steering Committee and Subcomittees. The local goals for Phase 1 will be to accomplish tasks (e.g., obtain regulatory approvals, train staff) that will enable Phase 2 to start at the beginning of Year 2. SA2: Recruit and enroll 450 adults at CU-AMC (or the number determined during Phase 1), conduct the acute PA tests and PA intervention according to protocols established by the Consortium, and carry out all other MoTrPAC Phase 2 activities (Years 2 to 5). Highly accomplished clinical investigators will lead the seven “teams” that will be responsible for: recruitment, screening, and retention; physiologic, metabolic, and morphometric phenotyping; biospecimen acquisition; biospecimen processing; acute PA tests; chronic PA interventions; and data management and quality assurance. SA3: As animal and human data become available from the Chemical Analysis Sites and Bioinformatics Center, we will participate in all Phase 3 activities, including data analysis, preparation of manuscripts, and dissemination of results. These activities will be guided by the MoTrPAC Steering Committee and Subcommittees. On the local level, we will host an annual 1-day local symposium on PA, Health, and Fitness to catalyze the interest of investigators at CU-AMC and other nearby academic institutions in MoTrPAC.

体力活动 (PA) 对健康和功能有许多深远的好处，但其效果有限 了解这些益处背后的机械信号。这些知识对于优化 有效利用 PA 作为特定疾病和特定疾病的预防或治疗干预策略 人口。身体活动分子传感器联盟 (MoTrPAC) 的总体目标是 通过表征对 PA 的分子反应来解决这一知识差距。这将实现 通过收集人类和动物的血液和组织样本，然后将其 进行广泛的“组学”分析。通过生成分子反应的综合图 PA、MoTrPAC 将为精确运动生物医学研究的新时代奠定基础 药品。科罗拉多大学安舒茨医学校区 (CU-AMC) 已做好充分准备 领导 MoTrPAC 成人临床中心并为联盟的所有活动做出贡献。我们的调查员和 合作者在复杂的临床 PA 干预试验方面拥有丰富的经验，包括组织采样、 在跨越整个成年人年龄范围的队列中。我们的专业知识涵盖多个生理领域 系统、疾病和健康状况，包括生理、代谢和健康方面的广泛熟练程度 形态测定表型。 CU-AMC 为 MoTrPAC 活动提供的设施非常出色。拟议的 MoTrPAC – 科罗拉多州临床中心将实现以下具体目标 (SA)： SA1：在适当的时候促进并领导所有 MoTrPAC 第 1 阶段规划活动（第 1 年）。 RFA-RM-15-015 通过参与 MoTrPAC 指导委员会和小组委员会。当地目标 第一阶段将完成任务（例如，获得监管批准、培训员工），使第二阶段能够 从第二年年初开始。 SA2：在 CU-AMC 招募并注册 450 名成年人（或第一阶段确定的人数），进行急性 根据联盟制定的协议进行 PA 测试和 PA 干预，并执行所有其他操作 MoTrPAC 第 2 阶段活动（第 2 至第 5 年）。成就卓著的临床研究人员将领导七名 “团队”将负责：招聘、筛选和保留；生理、代谢和 形态测定表型；生物样本采集；生物样本处理；急性 PA 测试；慢性PA 干预措施；以及数据管理和质量保证。 SA3：随着动物和人类数据可从化学分析站点和生物信息学获得 中心，我们将参与第三阶段的所有活动，包括数据分析、手稿准备，以及 传播结果。这些活动将由 MoTrPAC 指导委员会和 小组委员会。在地方层面，我们将每年举办一次为期 1 天的关于 PA、健康和健身的地方研讨会 激发 CU-AMC 和 MoTrPAC 附近其他学术机构研究人员的兴趣。