Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center

身体活动联盟分子传感器 - 科罗拉多临床中心

基本信息

批准号：
10840187
负责人：
Wendy M Kohrt
金额：
$ 200万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-12-06 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10840187
关键词：
17 year old 18 year old Acceleration Acute Adipose tissue Adult Age Ancillary Study Animals Attention Award Bioinformatics Biological Process Blood COVID-19 COVID-19 pandemic California Categories Charge Chemicals Child Childhood Chronic Clinical Clinical Protocols Clinical Research Clinical Trials Data Monitoring Committees Collaborations Collection Colorado Communication Communities Data Development Disease Disease Outcome Enrollment Ensure Ethnic Origin Exercise Frequencies Funding Gender Goals Health Health Benefit Heterogeneity Human Individual Institutional Review Boards Intervention Manuals Manuscripts Maps Measurement Minority Groups Molecular Multi-site clinical study Muscle Observational Study Participant Pathway interactions Pediatric cohort Phase Phenotype Physical activity Physiological Procedures Protocols documentation Public Health Race Randomized Randomized, Controlled Trials Recruitment Activity Research Research Personnel Resources Rest Site Suspensions Testing Time Tissues Training Transducers United States National Institutes of Health Universities Visit Woman Youth age group aged clinical center cohort comparison group endurance exercise ethnic minority exercise intervention exercise training falls follow-up improved innovation insight men multiple omics novel operation pandemic disease phenotypic data pre-clinical public database quality assurance racial minority recruit resistance exercise response sedentary sex working group

项目摘要

MoTrPAC Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) will discover and characterize the range of potential molecular transducers that underlie the health benefits of exercise in humans. MoTrPAC was launched in 2016 with six adult Clinical Centers and a pediatric Clinical Center that have collaborated to generate extensive Manuals of Operations to guide research protocols involving all aspects of clinical operations (Phase I). Phase II began in the fall of 2019 with all Clinical Centers demonstrating excellent progress toward initial recruitment goals and implementation of the protocol. The initial goal set forth by the Consortium was to recruit 270 children (10-17 years of age) and 1,980 sedentary adults (aged 18+ years of age) who are randomized to endurance exercise training (170 youth, 840 adults), resistance exercise training (840 adults), or no-exercise control (50 youth, 300 adults) interventions. Additional groups of highly active endurance trained (50 youth, 150 adults) or resistance trained (150 adults) individuals serve as comparator groups and do not undergo the MoTrPAC exercise interventions. The recruitment and enrollment approaches are sex balanced, with participants across a wide age range (10-17, 18-39, 40-59, and 60+ age groups) and of different races and ethnicity. Due to the COVID-19 pandemic, some MoTrPAC activities were suspended for more than a year, beginning in March 2020, with continued constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic, recruitment activities at the adult and pediatric Clinical Centers have accelerated to a rate that is projected to successfully achieve the target enrollment numbers by the end of the new award period. This led the NIH Common Fund to release the current NOFO (RFA-RM-23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized controlled trials of sedentary adults and children and observational studies of highly active adults and children. This will enrich the participant cohorts that are critical to understand the heterogeneity of exercise adaptations across age, gender, and minority groups. This extension will enable MoTrPAC to complete the intended goals as originally envisioned and will provide a more complete public database of the health benefits of exercise and provide insight into how physical activity mitigates disease.

MOTRPAC项目摘要体育活动联盟（MOTRPAC）的分子传感器将发现并表征潜在的分子传感器范围是人类运动的健康益处的基础。 motrpac 于2016年推出了六个成人临床中心和一个合作的儿科临床中心生成大量操作手册，以指导涉及临床各个方面的研究协议操作（第一阶段）。第二阶段始于2019年秋天，所有临床中心表现出极好的朝着初始招聘目标和协议的实施迈进。最初提出的目标该财团将招募270名儿童（10-17岁）和1,980名久坐的成年人（18岁以上年龄）随机进行耐力运动训练（170名青年，840名成人），抵抗运动训练（840名成人）或无运动控制（50名青年，300名成人）干预措施。其他组受过高度活跃的耐力训练（50名青年，150名成人）或受过抵抗的人（150名成人）用作比较组，不接受Motrpac运动干预措施。招募招生方法是性平衡的，参与者的年龄范围很广（10-17、18-39， 40-59岁和60岁以上的年龄段）以及不同的种族和种族。由于199大流行，有些从2020年3月开始，MOTRPAC活动被暂停了一年以上，继续到2022年的约束。尽管大流行而遇到了许多挑战，但成人和儿科临床中心的招聘活动已加速至预计在新奖励期结束时成功实现目标入学人数。这引发了 NIH公共基金释放当前的NOFO（RFA-RM-23-010），以向Motrpac提供资金临床研究的完整招募和随访，包括随机的完成机械久坐的成年人和儿童的对照试验以及高度活跃的成年人的观察性研究孩子们。这将丰富参与者的队列，这对于了解运动的异质性至关重要跨年龄，性别和少数群体的适应。此扩展名将使Motrpac完成最初设想的预期目标，并将提供更完整的健康数据库运动的好处，并洞悉身体活动如何减轻疾病。