Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center

身体活动联盟分子传感器 - 科罗拉多临床中心

• 批准号: 10840187
• 负责人: Wendy M Kohrt
• 金额: $ 200万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-06 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10840187
• 关键词: 17 year old; 18 year old; Acceleration; Acute; Adipose tissue; Adult; Age; Ancillary Study; Animals; Attention; Award; Bioinformatics; Biological Process; Blood; COVID-19; COVID-19 pandemic; California; Categories; Charge; Chemicals; Child; Childhood; Chronic; Clinical; Clinical Protocols; Clinical Research; Clinical Trials Data Monitoring Committees; Collaborations; Collection; Colorado; Communication; Communities; Data; Development; Disease; Disease Outcome; Enrollment; Ensure; Ethnic Origin; Exercise; Frequencies; Funding; Gender; Goals; Health; Health Benefit; Heterogeneity; Human; Individual; Institutional Review Boards; Intervention; Manuals; Manuscripts; Maps; Measurement; Minority Groups; Molecular; Multi-site clinical study; Muscle; Observational Study; Participant; Pathway interactions; Pediatric cohort; Phase; Phenotype; Physical activity; Physiological; Procedures; Protocols documentation; Public Health; Race; Randomized; Randomized, Controlled Trials; Recruitment Activity; Research; Research Personnel; Resources; Rest; Site; Suspensions; Testing; Time; Tissues; Training; Transducers; United States National Institutes of Health; Universities; Visit; Woman; Youth; age group; aged; clinical center; cohort; comparison group; endurance exercise; ethnic minority; exercise intervention; exercise training; falls; follow-up; improved; innovation; insight; men; multiple omics; novel; operation; pandemic disease; phenotypic data; pre-clinical; public database; quality assurance; racial minority; recruit; resistance exercise; response; sedentary; sex; working group

MoTrPAC Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) will discover and characterize the range of potential molecular transducers that underlie the health benefits of exercise in humans. MoTrPAC was launched in 2016 with six adult Clinical Centers and a pediatric Clinical Center that have collaborated to generate extensive Manuals of Operations to guide research protocols involving all aspects of clinical operations (Phase I). Phase II began in the fall of 2019 with all Clinical Centers demonstrating excellent progress toward initial recruitment goals and implementation of the protocol. The initial goal set forth by the Consortium was to recruit 270 children (10-17 years of age) and 1,980 sedentary adults (aged 18+ years of age) who are randomized to endurance exercise training (170 youth, 840 adults), resistance exercise training (840 adults), or no-exercise control (50 youth, 300 adults) interventions. Additional groups of highly active endurance trained (50 youth, 150 adults) or resistance trained (150 adults) individuals serve as comparator groups and do not undergo the MoTrPAC exercise interventions. The recruitment and enrollment approaches are sex balanced, with participants across a wide age range (10-17, 18-39, 40-59, and 60+ age groups) and of different races and ethnicity. Due to the COVID-19 pandemic, some MoTrPAC activities were suspended for more than a year, beginning in March 2020, with continued constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic, recruitment activities at the adult and pediatric Clinical Centers have accelerated to a rate that is projected to successfully achieve the target enrollment numbers by the end of the new award period. This led the NIH Common Fund to release the current NOFO (RFA-RM-23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized controlled trials of sedentary adults and children and observational studies of highly active adults and children. This will enrich the participant cohorts that are critical to understand the heterogeneity of exercise adaptations across age, gender, and minority groups. This extension will enable MoTrPAC to complete the intended goals as originally envisioned and will provide a more complete public database of the health benefits of exercise and provide insight into how physical activity mitigates disease.

MoTrPAC项目摘要 物理活动联盟的分子传感器（MoTrPAC）将发现和表征 一系列潜在的分子转换器，这些分子转换器是人类运动健康益处的基础。MoTrPAC 于2016年推出，有六个成人临床中心和一个儿科临床中心合作， 生成广泛的操作手册，以指导涉及临床各个方面的研究方案 （第一阶段）。第二阶段于2019年秋季开始，所有临床中心都表现出良好的 在实现初步招募目标和执行议定书方面取得的进展。提出的最初目标， 该联盟计划招募270名儿童（10-17岁）和1,980名久坐不动的成年人（18岁以上 年龄），随机接受耐力运动训练（170名青年，840名成人）， 运动训练（840名成人）或无运动对照（50名青年，300名成人）干预。附加组 高强度耐力训练（50名青年，150名成年人）或阻力训练（150名成年人） 作为对照组，不接受MoTrPAC运动干预。招募 入学方法是性别平衡的，参与者年龄范围很广（10-17岁，18-39岁， 40-59岁和60岁以上年龄组）和不同种族和民族。由于COVID-19大流行，一些 MoTrPAC的活动从2020年3月开始暂停了一年多， 到2022年的限制。尽管这一流行病带来了许多挑战， 成人和儿科临床中心的招募活动已经加速到预计的速度， 在新的奖励期结束前，成功达到目标人数。这导致 NIH共同基金发布当前NOFO（RFA-RM-23-010），为MoTrPAC提供资金， 完成临床研究的招募和随访，包括完成机械随机化 对久坐不动的成人和儿童进行的对照试验以及对高度活跃的成人和 孩子这将丰富参与者队列，这对于理解运动的异质性至关重要 跨年龄、性别和少数群体的适应。此扩展将使MoTrPAC能够完成 预期的目标，并将提供一个更完整的公共数据库的健康 运动的好处，并提供深入了解身体活动如何减轻疾病。

项目成果

The role of androgens in microvascular endothelial dysfunction in polycystic ovary syndrome: does size matter?

雄激素在多囊卵巢综合征微血管内皮功能障碍中的作用：大小重要吗？

• DOI: 10.1113/jp277961
• 发表时间: 2019
• 期刊: The Journal of physiology
• 作者: Moreau,KerrieL;DuBose,LyndseyE
• 通讯作者: DuBose,LyndseyE