Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center

MoTrPAC项目摘要 体力活动联盟的分子传感器(MoTrPAC)将发现和表征 一系列潜在的分子换能器，这些分子换能器是运动对人类健康有益的基础。MoTrPAC 成立于2016年，与六个成人临床中心和一个儿科临床中心合作 编写广泛的操作手册，以指导涉及临床各个方面的研究方案 运营(第一阶段)。第二阶段于2019年秋季开始，所有临床中心都表现出出色的 在实现初步招聘目标和执行议定书方面取得进展。最初的目标是由 该联盟招募270名儿童(10-17岁)和1,980名久坐不动的成年人(18岁以上 年龄)，随机接受耐力运动训练(170名青年，840名成年人)，抵抗 运动训练(840名成人)或不进行运动控制(50名青年，300名成人)干预。其他组 受过高度活动耐力训练(50名青年，150名成年人)或抵抗训练(150名成年人)的个人 作为对照组，不接受MoTrPAC运动干预。招聘 招生方式是性别平衡的，参与者的年龄范围很广(10-17岁，18-39岁， 40-59岁和60岁以上年龄组)以及不同种族和族裔。由于新冠肺炎大流行，一些人 MoTrPAC的活动从2020年3月开始暂停了一年多，并继续 到2022年的制约因素。尽管大流行带来了许多挑战， 成人和儿科临床中心的招聘活动加快到了预计的速度 在新的奖励期结束前成功达到目标招生人数。这导致了 NIH共同基金将发布当前的NOFO(RFA-RM-23-010)，为MoTrPAC提供资金 完成临床研究的招募和跟踪，包括完成机械性随机分组 久坐不动的成人和儿童的对照试验以及高度活跃的成人和 孩子们。这将丰富对理解运动的异质性至关重要的参与者队列 跨年龄、性别和少数群体的适应。此扩展将使MoTrPAC能够完成 最初设想的预期目标，并将提供一个更完整的公共健康数据库 锻炼的好处，并提供关于体育锻炼如何减轻疾病的洞察力。

MoTrPAC Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) will discover and characterize the range of potential molecular transducers that underlie the health benefits of exercise in humans. MoTrPAC was launched in 2016 with six adult Clinical Centers and a pediatric Clinical Center that have collaborated to generate extensive Manuals of Operations to guide research protocols involving all aspects of clinical operations (Phase I). Phase II began in the fall of 2019 with all Clinical Centers demonstrating excellent progress toward initial recruitment goals and implementation of the protocol. The initial goal set forth by the Consortium was to recruit 270 children (10-17 years of age) and 1,980 sedentary adults (aged 18+ years of age) who are randomized to endurance exercise training (170 youth, 840 adults), resistance exercise training (840 adults), or no-exercise control (50 youth, 300 adults) interventions. Additional groups of highly active endurance trained (50 youth, 150 adults) or resistance trained (150 adults) individuals serve as comparator groups and do not undergo the MoTrPAC exercise interventions. The recruitment and enrollment approaches are sex balanced, with participants across a wide age range (10-17, 18-39, 40-59, and 60+ age groups) and of different races and ethnicity. Due to the COVID-19 pandemic, some MoTrPAC activities were suspended for more than a year, beginning in March 2020, with continued constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic, recruitment activities at the adult and pediatric Clinical Centers have accelerated to a rate that is projected to successfully achieve the target enrollment numbers by the end of the new award period. This led the NIH Common Fund to release the current NOFO (RFA-RM-23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized controlled trials of sedentary adults and children and observational studies of highly active adults and children. This will enrich the participant cohorts that are critical to understand the heterogeneity of exercise adaptations across age, gender, and minority groups. This extension will enable MoTrPAC to complete the intended goals as originally envisioned and will provide a more complete public database of the health benefits of exercise and provide insight into how physical activity mitigates disease.