Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center

身体活动联盟分子传感器 - 科罗拉多临床中心

• 批准号: 10840187
• 负责人: Wendy M Kohrt
• 金额: $ 200万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-06 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10840187
• 关键词: 17 year old; 18 year old; Acceleration; Acute; Adipose tissue; Adult; Age; Ancillary Study; Animals; Attention; Award; Bioinformatics; Biological Process; Blood; COVID-19; COVID-19 pandemic; California; Categories; Charge; Chemicals; Child; Childhood; Chronic; Clinical; Clinical Protocols; Clinical Research; Clinical Trials Data Monitoring Committees; Collaborations; Collection; Colorado; Communication; Communities; Data; Development; Disease; Disease Outcome; Enrollment; Ensure; Ethnic Origin; Exercise; Frequencies; Funding; Gender; Goals; Health; Health Benefit; Heterogeneity; Human; Individual; Institutional Review Boards; Intervention; Manuals; Manuscripts; Maps; Measurement; Minority Groups; Molecular; Multi-site clinical study; Muscle; Observational Study; Participant; Pathway interactions; Pediatric cohort; Phase; Phenotype; Physical activity; Physiological; Procedures; Protocols documentation; Public Health; Race; Randomized; Randomized, Controlled Trials; Recruitment Activity; Research; Research Personnel; Resources; Rest; Site; Suspensions; Testing; Time; Tissues; Training; Transducers; United States National Institutes of Health; Universities; Visit; Woman; Youth; age group; aged; clinical center; cohort; comparison group; endurance exercise; ethnic minority; exercise intervention; exercise training; falls; follow-up; improved; innovation; insight; men; multiple omics; novel; operation; pandemic disease; phenotypic data; pre-clinical; public database; quality assurance; racial minority; recruit; resistance exercise; response; sedentary; sex; working group

MoTrPAC Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) will discover and characterize the range of potential molecular transducers that underlie the health benefits of exercise in humans. MoTrPAC was launched in 2016 with six adult Clinical Centers and a pediatric Clinical Center that have collaborated to generate extensive Manuals of Operations to guide research protocols involving all aspects of clinical operations (Phase I). Phase II began in the fall of 2019 with all Clinical Centers demonstrating excellent progress toward initial recruitment goals and implementation of the protocol. The initial goal set forth by the Consortium was to recruit 270 children (10-17 years of age) and 1,980 sedentary adults (aged 18+ years of age) who are randomized to endurance exercise training (170 youth, 840 adults), resistance exercise training (840 adults), or no-exercise control (50 youth, 300 adults) interventions. Additional groups of highly active endurance trained (50 youth, 150 adults) or resistance trained (150 adults) individuals serve as comparator groups and do not undergo the MoTrPAC exercise interventions. The recruitment and enrollment approaches are sex balanced, with participants across a wide age range (10-17, 18-39, 40-59, and 60+ age groups) and of different races and ethnicity. Due to the COVID-19 pandemic, some MoTrPAC activities were suspended for more than a year, beginning in March 2020, with continued constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic, recruitment activities at the adult and pediatric Clinical Centers have accelerated to a rate that is projected to successfully achieve the target enrollment numbers by the end of the new award period. This led the NIH Common Fund to release the current NOFO (RFA-RM-23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized controlled trials of sedentary adults and children and observational studies of highly active adults and children. This will enrich the participant cohorts that are critical to understand the heterogeneity of exercise adaptations across age, gender, and minority groups. This extension will enable MoTrPAC to complete the intended goals as originally envisioned and will provide a more complete public database of the health benefits of exercise and provide insight into how physical activity mitigates disease.

MoTrPAC 项目概要 体力活动分子传感器联盟 (MoTrPAC) 将发现并表征 一系列潜在的分子传感器是运动对人类健康有益的基础。莫特尔PAC 于 2016 年推出，与六个成人临床中心和一个儿科临床中心合作 生成广泛的操作手册来指导涉及临床各个方面的研究方案 运营（第一阶段）。第二阶段于 2019 年秋季开始，所有临床中心均表现出色 初步招募目标和议定书实施方面的进展。最初提出的目标是 该联盟计划招募 270 名儿童（10-17 岁）和 1,980 名久坐的成年人（18 岁以上） 岁），随机接受耐力运动训练（170 名青少年，840 名成人）、阻力 运动训练（840 名成人）或无运动控制（50 名青少年，300 名成人）干预措施。附加组 接受过高度活跃耐力训练（50 名青少年，150 名成人）或接受阻力训练（150 名成人）的个人 作为比较组，不接受 MoTrPAC 运动干预。招聘 招生方式性别平衡，参与者年龄范围广泛（10-17、18-39、 40-59 岁和 60 岁以上年龄组）以及不同种族和民族。由于 COVID-19 大流行，一些 自 2020 年 3 月开始，MoTrPAC 活动暂停了一年多， 到 2022 年，尽管疫情带来了诸多挑战， 成人和儿科临床中心的招募活动已加速到预计的速度 在新的奖励期结束时成功达到目标入学人数。这导致了 NIH 共同基金将发布当前的 NOFO (RFA-RM-23-010)，为 MoTrPAC 提供资金 完成临床研究的招募和随访，包括完成机械随机化 对久坐的成人和儿童进行的对照试验以及对高度活跃的成人和儿童进行的观察性研究 孩子们。这将丰富对于理解运动异质性至关重要的参与者群体 跨年龄、性别和少数群体的适应性。此扩展将使 MoTrPAC 能够完成 预期目标与最初设想一致，并将提供更完整的健康公共数据库 锻炼的好处，并深入了解身体活动如何减轻疾病。

项目成果

The role of androgens in microvascular endothelial dysfunction in polycystic ovary syndrome: does size matter?

雄激素在多囊卵巢综合征微血管内皮功能障碍中的作用：大小重要吗？

• DOI: 10.1113/jp277961
• 发表时间: 2019
• 期刊: The Journal of physiology
• 作者: Moreau,KerrieL;DuBose,LyndseyE
• 通讯作者: DuBose,LyndseyE