Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center

体力活动对健康和机能有许多深远的好处，但也是有限的 对这些好处背后的机械信号的了解。这些知识对于优化 有效利用PA作为特定疾病和特定疾病的预防或治疗干预策略 人口。体力活动分子传感器联合会(MoTrPAC)的首要目标是 通过表征对PA的分子反应来解决这一知识鸿沟。这将会实现的 通过采集人类和动物的血液和组织样本，这将是 受到广泛的“OMICS”分析。通过生成分子响应的综合图谱 PA，MoTrPAC将为精确锻炼的生物医学研究新纪元奠定基础 医学。科罗拉多大学安舒茨医学院(CU-AMC)非常有能力 领导MoTrPAC成人临床中心，并参与联合会的所有活动。我们的调查人员和 合作者在复杂的PA介入临床试验方面有丰富的经验，包括组织取样， 在跨越整个成年年龄段的队列中。我们的专业知识涵盖多个生理领域 系统、疾病和健康状况，包括对生理学、新陈代谢和 形态计量学表型。CU-AMC为MoTrPAC活动提供的设施非常出色。建议数 MoTrPAC-科罗拉多州临床中心将实现以下具体目标(SA)： SA1：适当时参与并领导所有MoTrPAC阶段1规划活动(第1年)，如中所述 RFA-RM-15-015，通过参加MoTrPAC指导委员会和与会者。地方目标 对于第一阶段，将完成任务(例如，获得监管批准、培训员工)，使第二阶段能够 从第二年开始。 SA2：在CU-AMC招募和招收450名成年人(或在第一阶段确定的人数)，进行急性 根据联盟制定的协议进行PA测试和PA干预，并执行所有其他 MoTrPAC第二阶段活动(第2至第5年)。非常有成就的临床研究人员将领导这七个 将负责：招募、筛选和保留；生理、代谢和 形态计量学表型；生物样品获取；生物样品加工；急性PA试验；慢性PA 干预措施；数据管理和质量保证。 SA3：随着动物和人类数据从化学分析站点和生物信息学获得 我们将参与所有第三阶段的活动，包括数据分析、手稿准备和 传播成果。这些活动将由MoTrPAC指导委员会指导，并 小组委员会。在地方层面上，我们将每年举办一次为期一天的关于PA、健康和健身的地方研讨会 激发CU-AMC和其他附近学术机构的研究人员对MoTrPAC的兴趣。

Physical activity (PA) has numerous and profound benefits on health and function, yet there is limited knowledge of the mechanistic signals that underlie these benefits. Such knowledge is critical for optimizing the effective use of PA as a preventive or therapeutic intervention strategy for specific diseases and in specific populations. The overarching goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to address this knowledge gap by characterizing the molecular responses to PA. This will be accomplished through the collection of blood and tissue samples from both humans and animals, which will then be subjected to extensive “Omics” analyses. By generating a comprehensive map of molecular responses to PA, MoTrPAC will lay the foundation for a new era of biomedical research on Precision Exercise Medicine. The University of Colorado Anschutz Medical Campus (CU-AMC) is exceptionally well poised to lead a MoTrPAC Adult Clinical Center and to contribute to all Consortium activities. Our investigators and collaborators have extensive experience with complex clinical PA intervention trials, including tissue sampling, in cohorts spanning the entire adult age spectrum. Our expertise extends across multiple physiological systems, diseases, and health conditions, and includes broad proficiency in physiologic, metabolic, and morphometric phenotyping. The facilities at CU-AMC for MoTrPAC activities are outstanding. The proposed MoTrPAC – Colorado Clinical Center will accomplish the following Specific Aims (SA): SA1: Contribute to, and lead when appropriate, all MoTrPAC Phase 1 planning activities (Year 1) described in RFA-RM-15-015 through participation on the MoTrPAC Steering Committee and Subcomittees. The local goals for Phase 1 will be to accomplish tasks (e.g., obtain regulatory approvals, train staff) that will enable Phase 2 to start at the beginning of Year 2. SA2: Recruit and enroll 450 adults at CU-AMC (or the number determined during Phase 1), conduct the acute PA tests and PA intervention according to protocols established by the Consortium, and carry out all other MoTrPAC Phase 2 activities (Years 2 to 5). Highly accomplished clinical investigators will lead the seven “teams” that will be responsible for: recruitment, screening, and retention; physiologic, metabolic, and morphometric phenotyping; biospecimen acquisition; biospecimen processing; acute PA tests; chronic PA interventions; and data management and quality assurance. SA3: As animal and human data become available from the Chemical Analysis Sites and Bioinformatics Center, we will participate in all Phase 3 activities, including data analysis, preparation of manuscripts, and dissemination of results. These activities will be guided by the MoTrPAC Steering Committee and Subcommittees. On the local level, we will host an annual 1-day local symposium on PA, Health, and Fitness to catalyze the interest of investigators at CU-AMC and other nearby academic institutions in MoTrPAC.