Delaware Clinical and Translational Research ACCEL Program (BERD Core)

特拉华州临床和转化研究 ACCEL 计划（BERD 核心）

• 批准号: 10721015
• 负责人: CATHY H. WU
• 金额: $ 62.86万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-25 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10721015
• 关键词: Address; Ally; Area; Artificial Intelligence; Behavioral; Bioinformatics; Biometry; Biostatistical Methods; Biostatistics Core; Child Health; Clinical; Clinical Investigator; Clinical Research; Cloud Computing; Collaborations; Community Health; Computers; Data; Data Science; Databases; Delaware; Disease; Education; Electronic Health Record; Environment; Epidemiologist; Epidemiology; Equity; Fostering; Funding; Goals; Grant; Health; Health Sciences; Health Services; Health system; Healthcare; Historically Black Colleges and Universities; Individual; Infrastructure; Institution; Knowledge; Learning; Machine Learning; Medical; Methodology; Methods; Natural Language Processing; Phase; Population; Positioning Attribute; Process; Research; Research Design; Research Infrastructure; Research Institute; Research Personnel; Resources; Scientist; Selection Bias; Series; Services; Source; South Carolina; Statistical Data Interpretation; Translational Research; Universities; Vulnerable Populations; biomedical informatics; design; health disparity; health equity; health inequalities; improved; innovation; insight; interest; lectures; minority health; novel; population health; programs; skill acquisition; skills; tool; translational scientist; virtual; voucher

ABSTRACT - BERD The Biostatistics, Epidemiology and Research Design (BERD) Core of the Delaware ACCEL CTR has matured in the last 9 years into a large, stable yet dynamic core with a repertoire of skills and resources that enables quality clinical and translational (C&T) research. BERD’ s accomplishments result from the close collaboration between ACCEL partner institutions: the University of Delaware, the Nemours Children’ Health system, ChristianaCare Health Services Inc., the Medical University of South Carolina and Delaware State University. BERD assembles a diverse core of skilled biostatisticians, epidemiologists, and bioinformaticians from each Institution who have the common goal of advancing translational science and assist C&T investigators. The BERD team from MUSC was instrumental in helping us launch and develop a strong, sustainable BERD over the last nine years, but the DE-based BERD team has matured to a point of independence. Phase 3 BERD (without MUSC) will build on this momentum to meet the evolving skills needed for C&T research. With the increasing availability of vast amounts of data, we have the potential to provide deeper insight into the determinants of disease at the individual and population level. To do so, we must develop new methodologies and tools to analyze these data. We will enrich the BERD resources with expertise in Machine Learning (ML), Natural language Processing (NLP), cloud computing, geospatial analysis and novel biostatistics methods to address health disparities. We propose the following specific aims:1) Expand and enrich consultative services for clinical, translational, population health sciences. BERD will leverage the expertise in ML, NLP, cloud computing, and geospatial analysis that already exists in some ACCEL-CTR Institutions and will make this expertise available to all Investigators; 2) Develop innovative methods in biostatistics and data sciences including reducing selections biases, enhancing the power of studies, and developing design and analysis plans for studies of vulnerable populations or very small numbers of subjects; 3) Promote virtual self-paced synchronous and asynchronous learning opportunities. We will continue to offer TechTalks and Innovative Discoveries Series lectures and will vet on-line material for posting on our Education hub; 4) Expand the biomedical informatics research infrastructure by leveraging expertise and skills acquired in the last nine years to establish an integrated network of resources focused on addressing critical healthcare needs in Delaware. The BERD specific aims build upon the overall aims of the ACCEL CTR phase 3. By expanding BERD expertise to better meet the needs of Investigators, we will improve the scientific infrastructure and culture. We will develop Innovative methodologies to foster projects aiming at improving health equity. Access to the cloud will allow teams of clinicians and scientists to develop projects that have high clinical impact. Access to asynchronous learning will help clinician researchers to sharpen their skills in biostatistics/epidemiology.

摘要-BERD 特拉华州ACCEL CTR的生物统计学、流行病学和研究设计（BERD）核心已经成熟 在过去的9年里，成为一个庞大、稳定而充满活力的核心，拥有一系列技能和资源，能够 高质量的临床和转化（C & T）研究。BERD的成就来自于我们的紧密合作 ACCEL合作机构之间：特拉华州大学，内穆尔儿童健康系统， ChristianaCare Health Services Inc.，南卡罗来纳州医科大学和特拉华州州立大学。 BERD汇集了来自各个领域的熟练生物统计学家，流行病学家和生物信息学家的多样化核心。 共同目标是促进转化科学的发展，并协助C & T研究人员的机构。的 来自MUSC的BERD团队帮助我们推出和开发了一个强大的，可持续的BERD， 在过去的九年里，以DE为基础的BERD团队已经成熟到了独立的程度。第3阶段BERD （没有MUSC）将在这一势头的基础上，以满足C & T研究所需的不断发展的技能。与 随着大量数据的可用性不断提高，我们有可能更深入地了解 在个人和群体水平上的疾病决定因素。为此，我们必须制定新的方法 和工具来分析这些数据。我们将用机器学习（ML）的专业知识丰富BERD资源， 自然语言处理（NLP）、云计算、地理空间分析和新颖的生物统计学方法， 解决健康差距问题。我们提出以下具体目标：1）扩大和丰富咨询服务 用于临床、转化、人口健康科学。BERD将利用ML，NLP，云计算方面的专业知识 计算和地理空间分析，已经存在于一些ACCEL-CTR机构，并将使这一点 为所有研究者提供专业知识; 2）开发生物统计学和数据科学的创新方法 包括减少选择偏差，增强研究的力量，以及开发设计和分析 计划对弱势群体或极少数受试者进行研究; 3）促进虚拟自定进度 同步和异步学习机会。我们将继续提供技术讲座和创新 发现系列讲座，并将审查在线材料张贴在我们的教育中心; 4）扩大 生物医学信息学研究基础设施，利用过去九年获得的专业知识和技能 建立一个综合资源网络，重点解决特拉华州的关键医疗保健需求。 BERD的具体目标建立在ACCEL CTR第3阶段的总体目标之上。通过扩展BERD 为了更好地满足研究人员的需求，我们将改善科学基础设施和文化。我们 将开发创新方法，以促进旨在改善卫生公平的项目。访问云 将允许临床医生和科学家团队开发具有高度临床影响的项目。获得 异步学习将帮助临床研究人员提高他们在生物统计学/流行病学方面的技能。