Cancer Cell Biology Training Program

摘要 本申请旨在延续北卡罗来纳大学教堂山分校(北卡罗来纳大学)S的长期 和非常成功的癌症细胞生物学培训计划(CCBTP)，旗舰和唯一的博士前培训计划 北卡罗来纳大学莱恩伯格综合癌症中心专注于癌症的T32。CCBTP现已进入第25个年头。因为我们 总是有更多的高素质的申请者超过了我们的容纳能力，我们要求为所有六人提供续签支持 博士前培训时段。CCTBP的前提是癌细胞生物学是一门交叉学科 生物医学包括实验方法和来自不同领域的教学知识。这个 CCBTP的使命是培养下一代基础和翻译癌症生物学家，为他们做好准备 在学术和非学术事业上都做出贡献。作为一个不授予学位的项目，CCBTP提供 受训人员拥有部门要求和产品之外的独特机会。在这次更新中 应用，CCBTP寻求在过去成功的基础上，同时也认识到癌症研究的格局 培训已经进入了一个非常动态变化的新时代。精准医疗与大数据基因组时代 在癌症方面，研究继续以极快的速度发展。技术的戏剧性进步使 加深了对单个细胞对特定群体的贡献，以及对 癌细胞与其肿瘤微环境的间质和免疫细胞有关。保持CCBTP计划的新鲜性 为了更好地满足未来癌症生物学实习生的需求，我们对该计划进行了严格的评估，并 重新调整了一些方面，以跟上这一不断变化的格局。因此，我们更新的程序包括一个 修订了癌症病理生物学和信号转导的核心课程，这是一门专门为CCBTP开发的新核心课程 关于癌症免疫学和肿瘤微环境，以及我们关于靶向癌症的独特体验课程 治疗学。在过去的周期中，CCBTP增加了与教师导师的新互动，提高了多样性 正在筹备中，并获得了更多的机构支持。我们继续在所有这些改进的基础上再接再厉。vbl.去，去 展望未来，除了继续强调基础癌症生物学和转译癌症生物学之外，受训人员还有新的 有机会开发和利用其最先进的方法知识，以分析和剖析 癌症基因组、基因组和蛋白质组；熟悉生物信息学和计算生物学； 参与快速发展的免疫治疗领域和肿瘤微环境；了解和 应用最合适和最有用的模型系统来研究癌症生物学；加强严谨和 他们的研究的可重复性；并深思熟虑地与自己实验室和 机构。CCBTP学员将他们的社区描述为其 博士前培训。CCBTP在我们支持未来管道的培训任务中发挥着至关重要的作用 癌症生物学家，让他们做好准备，加快了解和治疗癌症的进展。

Abstract This application seeks the continuation of the University of North Carolina at Chapel Hill (UNC)'s longstanding and highly successful Cancer Cell Biology Training Program (CCBTP), the flagship and sole predoctoral-only cancer-focused T32 of UNC's Lineberger Comprehensive Cancer Center. CCBTP is now in its 25th year. As we always have more highly qualified applicants than we can accommodate, we request renewed support for all six predoctoral training slots. The premise of CCTBP is that the biology of cancer cells is an interdisciplinary biomedical science encompassing experimental approaches and didactic knowledge from diverse fields. The CCBTP mission is to train the next generation of basic and translational cancer biologists, preparing them to contribute in both academic and non-academic careers. As a non degree-granting program, CCBTP provides trainees with unique opportunities beyond their departmental requirements and offerings. In this renewal application, CCBTP seeks to build on past success, while also recognizing that the landscape of cancer research and training has entered a new era of very dynamic change. Precision medicine and the genomic era of big data in cancer research continue to evolve at warp speed. Dramatic improvements in technology have enabled increased understanding of the contributions of single cells to specific populations, and to the interactions of cancer cells with their tumor microenvironment of stromal and immune cells. To keep the CCBTP program fresh and to best address the needs of future cancer biology trainees, we have critically evaluated the program and remodeled some aspects to keep abreast of this changing landscape. Our refreshed program thus includes a revised core course on cancer pathobiology and signaling, a new core course developed specifically for CCBTP on cancer immunology and the tumor microenvironment, and our unique experiential course on targeted cancer therapeutics. In the past cycle, CCBTP added novel interactions with faculty mentors, improved the diversity pipeline, and obtained enhanced institutional support. We continue to build on all of these improvements. Going forward, in addition to continued emphasis on both basic and translational cancer biology, trainees have new opportunities to develop and utilize their knowledge of state-of-the-art methodologies to profile and dissect the cancer genome, kinome and proteome; to become familiar with bioinformatics and computational biology; to engage with the rapidly emerging areas of immunotherapy and the tumor microenvironment; to understand and apply the most appropriate and useful model systems to study cancer biology; to enhance the rigor and reproducibility of their research; and to engage thoughtfully with the larger world outside their own labs and institution. CCBTP trainees describe their community as one of the most important and valuable aspects of their predoctoral training. The CCBTP serves a vital role in our mission of training to support the pipeline of future cancer biologists, preparing them to accelerate progress in the understanding and treatment of cancer.