Cancer Cell Biology Training Program

摘要 本申请旨在继续我们的T32癌细胞生物学培训计划（CCBTP），现在在其第19届 年这个专门的博士前培训计划，连同长期的专门博士后 癌症模型系统综合培训（ITCMS）T32，包括Lineberger的培训部分 位于北卡罗来纳大学教堂山的综合癌症中心（LCCC）。LCCC是仅有的45个NCI指定之一 综合癌症中心。CCTP的前提是，癌细胞生物学是一个独特的，跨学科的 生物医学科学，包括实验方法和来自不同领域的教学知识， 如生物化学，细胞生物学，流行病学，遗传学，免疫学，微生物学，分子生物学，病理学， 药理学、生理学和毒理学。CCBTP的使命一直是，并将继续是，培训 下一代基础和转化癌症生物学家。由于我们不是一个学位授予计划，我们 寻求为我们的学生提供超出他们部门要求的独特机会。在这次更新中， 应用，CCBTP寻求建立在其过去的成功，同时也认识到， 研究和培训已进入一个充满活力的新时代。随着精确度的提高 医学，以及癌症研究的基因组时代继续以曲速前进，这些现在是最好的一些 癌症研究的时代。相反，这些也是具有挑战性的时代。我们面对的信息 我们必须确保我们的学员能够利用这些信息来推进他们自己的研究 问题研究资助继续挑战研究界。可重复性的问题， 其他研究领域。制药业不再能够维持自己的研究能力， 改变产业界和学术界之间的动态。为了保持CCBTP计划的新鲜感，并解决 为了满足未来癌症生物学学员的需求，我们对该计划进行了严格的评估，并对一些 以跟上这一不断变化的景观方面。核心使命仍然是确保我们提供 最好的培训我们的癌症生物学学生。我们现在还专注于为我们的学员做好学术准备， 非学术职业。在过去的周期中，我们增加了与教师导师的新颖互动， 我们的多元化管道，并获得了加强机构的支持。展望未来，除了我们继续 强调转化癌症生物学，我们将为我们的学员提供新的机会，发展他们的 了解最先进的方法来分析和解剖癌症基因组，生物信息学和 计算生物学，免疫治疗和表观遗传学的新兴领域，最好的模型系统， 研究癌症和研究的可重复性。CCBTP在培训的使命中发挥着至关重要的作用， 支持未来癌症生物学家的管道，准备他们在NCI癌症中担任领导角色 此外，该项目还将支持“登月计划”，并加快在癌症预防、诊断和治疗方面的进展。

ABSTRACT This application seeks continuation of our T32 Cancer Cell Biology Training Program (CCBTP), now in its 19th year. This exclusively predoctoral training program, together with the long-standing exclusively postdoctoral Integrated Training in Cancer Model Systems (ITCMS) T32, comprise the training component of the Lineberger Comprehensive Cancer Center (LCCC) at UNC-Chapel Hill. LCCC is one of only 45 NCI-designated Comprehensive Cancer Centers. The CCTP premise is that cancer cell biology is a distinct, interdisciplinary biomedical science that encompasses experimental approaches and didactic knowledge from fields as diverse as biochemistry, cell biology, epidemiology, genetics, immunology, microbiology, molecular biology, pathology, pharmacology, physiology and toxicology. The CCBTP mission has been, and continues to be, training the next generation of basic and translational cancer biologists. Since ours is not a degree-granting program, we seek to provide our students with unique opportunities beyond their departmental requirements. In this renewal application, the CCBTP seeks to build on its past success, while also recognizing that the landscape of cancer research and training has entered a new era of very dynamic change. With the approach of precision medicine, and the genomic era of cancer research continuing at warp speed, these are now some of the best of times for cancer research. Conversely, these are also challenging times. We are faced with information overload and must ensure that our trainees can leverage this information to advance their own research studies. Grant funding continues to challenge the research community. Issues of reproducibility dog this and other research fields. The pharmaceutical industry is no longer able to sustain its own research capabilities, changing the dynamics between industry and academia. To keep the CCBTP program fresh and to address the needs of future cancer biology trainees, we have critically evaluated the program and remodeled some aspects to keep abreast of this changing landscape. The core mission remains to ensure that we provide the best training for our cancer biology students. We also now focus on preparing our trainees for both academic and non-academic careers. In the past cycle, we have added novel interactions with faculty mentors, improved our diversity pipeline, and obtained enhanced institutional support. Going forward, in addition to our continued emphasis on translational cancer biology, we will provide our trainees with new opportunities to develop their knowledge of state-of-the-art methodologies to profile and dissect the cancer genome, bioinformatics and computational biology, the emerging areas of immunotherapy and epigenetics, the best model systems to study cancer, and reproducibility in research. The CCBTP serves a vital role in the mission of training to support the pipeline of future cancer biologists, preparing them to serve leading roles in the NCI Cancer Moonshot Initiative, and to accelerate progress in the prevention, diagnosis and treatment of cancer.