Biostatistics Core - RC1

生物统计学核心 - RC1

• 批准号: 10728746
• 负责人: Qian-Li Xue
• 金额: $ 23.85万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10728746
• 关键词: Address; Aging; American; Area; Basic Science; Biological; Biostatistics Core; Capital; Clinical; Collaborations; Collection; Communities; Complex; Computer Hardware; Computer software; Data; Data Analyses; Data Analytics; Databases; Dedications; Development; Disparity; Documentation; Effectiveness; Elderly; Engineering; Ensure; Etiology; Funding; Genomics; Gerontology; Goals; Health; Health Promotion; Housing; Informatics; Infrastructure; Institution; Intervention; Knowledge; Leadership; Life; Life Cycle Stages; Measurement; Measures; Mentors; Mentorship; Methodology; Methods; Modernization; Online Systems; Outcome; Pattern Recognition; Phenotype; Physiological; Population Attributable Risks; Populations at Risk; Prevention strategy; Property; Public Health Practice; Registries; Reproducibility of Results; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Risk Factors; Role; Scholarship; Science; Scientist; Secure; Signal Transduction; Site; Specificity; Statistical Data Interpretation; Syndrome; System; Technology; Technology Assessment; Training; Translating; Translational Research; Translations; Work; career; clinical practice; clinical translation; cohort; data complexity; data infrastructure; data management; design; education research; empowerment; endophenotype; experience; faculty mentor; faculty support; frailty; high dimensionality; innovation; middle age; molecular marker; new technology; next generation; pilot test; prevent; sound; statistics; success; synergism; tool; translational study; web site

RC1 – Biostatistics Core: Project Summary Since mid-2003, this OAIC Biostatistics Core (RC1) has dedicated critically needed resources toward the quantitative challenges of research on frailty. Partnering in OAIC leadership, and working closely with other OAIC resource cores, it has helped develop the careers of an interdisciplinary cohort of junior faculty supported by the Research Education Component (REC)—and beyond—and ensured expert design and analysis of pilot, external, and de novo studies needed to advance science on frailty. It now proposes to continue in these efforts, by providing: (1) mentorship for junior faculty supported by our REC, and our broader OAIC, in developing careers focused on frailty and aging; (2) new data and computing infrastructure and software, including web-based data housing and acquisition tools; (3) expertise for science on frailty, through support for the design, statistical analysis, and data management of research projects, and through making available new data analytic methodologies that are essential to studying the complex syndrome of frailty; and (4) leadership and visibility for frailty-related scientific and health promotion endeavors at Johns Hopkins, throughout the OAIC network, and in the broader gerontological community. Our support and leadership in these areas have been significant and wide-reaching, and could not be provided without the resources of this Core. The leadership is experienced, expert, deeply immersed in scholarship on aging, and visible in both gerontology and statistics. The Core will continue to support every REC and pilot-supported investigator as per their need. The Core synergizes actively with other OAIC resource cores, as evidenced by progress over the last cycle. Our team includes a statistical genomics expert to enhance our collaborations with the Biological Mechanisms Core (RC2). We also have engaged an internal consultant with expertise in signal intensive measurement to enhance our interactions with our new Technological Assessment and Solutions Core (RC4). We will continue to provide design and analytic expertise and support a Registry collaboratively with the Clinical Translation Core (RC3). Regarding new methodologies: research will develop approaches needed to better (i) assess prefrailty, hence identify at-risk persons early enough to intervene successfully; (ii) delineate heterogeneous etiology underlying frailty; (iii) design studies to assess frailty intervention; (iv) characterize attributable fraction of frailty risk factors over the lifecourse, and (v) address frailty disparities. By efforts along all these lines, this Core will contribute crucially to the success of this OAIC in answering a next generation of questions on frailty, and achieving findings' translation toward increased independence of older persons.

RC 1-生物统计学核心：项目摘要 自2003年年中以来，OAIC生物统计学核心（RC 1）将急需的资源用于 脆弱性研究的定量挑战。与国际审计和调查办公室领导层合作，并与其他 OAIC资源核心，它帮助发展了一批跨学科的初级教师的职业生涯 由研究教育组成部分（REC）的支持-和超越-并确保专家设计和 分析试点，外部和从头研究需要推进科学脆弱。现建议 继续在这些努力，通过提供：（1）导师为初级教师支持我们的REC，和我们的 更广泛的OAIC，发展专注于脆弱和老化的职业生涯;（2）新的数据和计算基础设施 和软件，包括基于网络的数据存储和获取工具;（3）脆弱性科学的专业知识， 通过支持研究项目的设计、统计分析和数据管理， 提供新的数据分析方法，这对研究复杂的综合征至关重要， 脆弱性;（4）领导和可见性的脆弱性相关的科学和健康促进工作在约翰 霍普金斯，整个OAIC网络，并在更广泛的老年学社区。我们的支持和 在这些领域的领导作用是重要的和广泛的，如果没有 这个核心的资源。领导层经验丰富，专家，深深沉浸在老龄化的学术， 在老年学和统计学上都可以看到。核心将继续支持每一个区域经济共同体和试点支持 调查人员根据需要。该核心与其他OAIC资源核心积极协同， 上一个周期的进展。我们的团队包括一名统计基因组学专家，以加强我们的合作 生物机制核心（RC 2）我们还聘请了一名内部顾问， 信号密集型测量，以加强我们与新技术评估的互动， 解决方案核心（RC 4）。我们将继续提供设计和分析专业知识，并支持注册表 临床翻译核心（RC 3）关于新方法：将开展研究 需要采取更好的方法：（i）评估易感性，从而及早识别高危人群，以便进行干预 成功地;（ii）描述潜在虚弱的异质性病因;（iii）设计评估虚弱的研究 干预;（iv）表征生命过程中虚弱风险因素的可归因分数，以及（v）解决 脆弱的差异通过沿着所有这些路线的努力，该核心将为该OAIC的成功做出至关重要的贡献 在回答下一代关于脆弱的问题，并实现研究结果的翻译， 老年人的独立性。