Conduct of studies to evaluate the toxic and carcinogenic potential of naturally occurring asbestos and related mineral fibers in laboratory animals

本项目的目标是为转化毒理学司（DTT）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要适当进行毒理学研究，以确保所得数据可靠。该项目涉及开展方法开发工作，以支持设计和开展大鼠经鼻吸入暴露后多种不同矿物纤维的毒性和致癌性研究。美国各地对这些矿物纤维的来源存在担忧，并且存在围绕相对效力之间相似性的问题。该项目的数据将用于制定关于天然石棉和相关矿物纤维对大鼠的潜在毒性和致癌性的合理科学结论，并最终支持DTT的使命和目标以及其他联邦机构的风险评估活动。此外，公众可以充分了解接触天然石棉和相关矿物纤维所产生的危险因素。 关键词：毒性，致癌性，石棉，吸入，纤维，肺

The goal of this project is to provide support of the Division of Translational Toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of method development work to support the design and conduct of toxicity and carcinogenicity studies of multiple, diverse mineral fibers in rats, following exposure by nose-only inhalation. There are concerns over sources of these mineral fibers across the USA, and there are questions surrounding similarities among relative potencies. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of naturally occurring asbestos and related mineral fibers in rats and ultimately supports the mission and goals of DTT and risk assessment activities of other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to naturally occurring asbestos and related mineral fibers. Keywords: toxicity, carcinogenicity, asbestos, inhalation, fiber, lung