Conduct of studies to evaluate the toxic and carcinogenic potential of naturally occurring asbestos and related mineral fibers in laboratory animals

该项目的目标是为转化毒理学司（DTT）的危险识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理剂而引起的疾病或不利影响。毒性试验是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要进行适当的毒理学研究，以确保得出的数据可靠。该项目涉及开展方法开发工作，以支持设计和开展多种不同矿物纤维在大鼠中仅通过鼻子吸入暴露后的毒性和致癌性研究。人们对美国各地这些矿物纤维的来源感到担忧，并且对相对效力的相似性存在疑问。该项目的数据将用于对天然石棉和相关矿物纤维在大鼠体内的潜在毒性和致癌性得出合理的科学结论，并最终支持数字地面电视的使命和目标以及其他联邦机构的风险评估活动。此外，公众可充分了解因接触天然石棉和有关矿物纤维而产生的风险因素。

The goal of this project is to provide support of the Division of Translational Toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of method development work to support the design and conduct of toxicity and carcinogenicity studies of multiple, diverse mineral fibers in rats, following exposure by nose-only inhalation. There are concerns over sources of these mineral fibers across the USA, and there are questions surrounding similarities among relative potencies. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of naturally occurring asbestos and related mineral fibers in rats and ultimately supports the mission and goals of DTT and risk assessment activities of other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to naturally occurring asbestos and related mineral fibers. Keywords: toxicity, carcinogenicity, asbestos, inhalation, fiber, lung