Neural basis of the thermal instability that leads to menopausal hot flushes

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Hot flushes and night sweats affect 80-90% of women during the menopause transition. In 20% of women these symptoms are severe. The mechanisms are not well understood, and non-hormonal treatments are urgently needed. We can investigate the basic brain mechanisms in an animal model, the sheep. The findings will elucidate the mechanisms that disrupt normal temperature regulation and thus lead the way to better therapies for this common, and often debilitating, condition. .