Neural basis of the thermal instability that leads to menopausal hot flushes

导致更年期潮热的热不稳定性的神经基础

• 批准号: nhmrc : 1051104
• 负责人: Dr Michael Mckinley
• 金额: $ 22.04万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neural-basis-thermal-hot-flushes/112196
• 关键词: Neural; basis; thermal; instability; leads

Hot flushes and night sweats affect 80-90% of women during the menopause transition. In 20% of women these symptoms are severe. The mechanisms are not well understood, and non-hormonal treatments are urgently needed. We can investigate the basic brain mechanisms in an animal model, the sheep. The findings will elucidate the mechanisms that disrupt normal temperature regulation and thus lead the way to better therapies for this common, and often debilitating, condition. .

潮热和盗汗会影响80%-90%的更年期妇女。在20%的女性中，这些症状是严重的。其机制尚不清楚，迫切需要非激素治疗。我们可以在动物模型绵羊身上研究基本的大脑机制。这些发现将阐明扰乱正常体温调节的机制，从而为这种常见的、往往使人虚弱的疾病找到更好的治疗方法。。