The nature of CNS circuitry subserving thirst.

中枢神经系统电路的本质是促进口渴。

• 批准号: nhmrc : 350437
• 负责人: Dr Michael Mckinley
• 金额: $ 15.1万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nature-cns-circuitry-subserving-thirst/94579
• 关键词: nature; CNS; circuitry; subserving; thirst.

Fluid intake is essential for survival. Disorders of thirst whether they be excessive or inadequate have dire conseqences as evidenced in recent heat waves in Europe and Indiawhere thousands of lives were lost primarily in the elderly whose thirst mechanisms are often disrupted. The excessive fluid intake, seen in psychotic disorders such as schizophrenia, is equally damaging. Much of the research over the last 50 years has concentrated on the hypothalamic regulation of thirst. This project will attempt, for the first time, to define the location in the cerebral cortex of the drive to ingest water (perception of thirst).

液体摄入对生存至关重要。口渴失调，无论是过度的还是不足的，都会造成可怕的后果，欧洲和印度最近的热浪就证明了这一点，在那里，成千上万的人丧生，主要是老年人，他们的口渴机制经常受到干扰。在精神分裂症等精神疾病中看到的过量液体摄入同样具有破坏性。过去50年的大部分研究都集中在下丘脑对口渴的调节上。该项目将首次尝试确定大脑皮层中饮水驱动（口渴感知）的位置。