METABOLIC REMODELING OF THE HUMAN RED BLOOD CELL MEMBRANE

人红细胞膜的代谢重塑

• 批准号: 8364153
• 负责人: YOUNGKYU PARK
• 金额: $ 2.23万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364153
• 关键词: Biochemical; Biomedical Research; Cell membrane; Characteristics; Erythrocytes; Funding; Grant; Human; Lasers; Measures; Membrane; Metabolic; Microscope; Morphology; National Center for Research Resources; Phase; Principal Investigator; Research; Research Infrastructure; Resources; Shapes; Source; Structure; United States National Institutes of Health; cost

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The RBC membrane is not a static but a metabolically regulated active structure. It is known that biochemical energy controls its static and dynamic characteristics. The presence of ATP is not only crucial in maintaining the biconcave shape of the RBC membrane, but was also shown to increase the dynamic membrane fluctuations. However, the regulatory mechanism of ATP in RBC membranes still remains elusive. We investigate the effects of ATP by measuring the morphologies and membrane dynamics of RBC using the quantitative phase microscopes we developed.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 红细胞膜不是静态的，而是代谢调节的活性结构。众所周知，生化能控制其静态和动态特性。ATP的存在不仅对维持红细胞膜的双凹形状至关重要，而且还显示出增加动态膜波动。然而，红细胞膜ATP的调节机制仍然是难以捉摸的。我们研究ATP的影响，通过测量红细胞的形态和膜动力学，使用我们开发的定量相显微镜。