DYNAMICS OF RED BLOOD CELLS INFECTED BY P FALCIPARUM

恶性疟原虫感染的红细胞的动态变化

• 批准号: 8364144
• 负责人: YOUNGKYU PARK
• 金额: $ 2.23万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364144
• 关键词: Actins; Binding Sites; Biomedical Research; Cell membrane; Cytoskeleton; Defect; Dissociation; Erythrocytes; Funding; Grant; Human; Invaded; Lasers; Malaria; Membrane; Metabolic; Microscopy; National Center for Research Resources; Organism; Parasites; Phase; Phospholipids; Plasmodium falciparum; Principal Investigator; Research; Research Infrastructure; Resources; Source; Spectrin; Staging; Stress; United States National Institutes of Health; cost; human disease; nanomechanical; protein transport; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Cell membrane dynamic responses can be influenced by the onset and progression of human diseases. Fluctuations in the phospholipid bilayer and attached spectrin cytoskeleton are known to be altered by cytoskeletal defects, stress, and actin-spectrin dissociations arising from metabolic activity. Proteins transported from invading organisms, such as the malaria-inducing parasite P. falciparum, to specific binding sites in the spectrin cytoskeletal network induce significant alterations to RBC membrane dynamics and nanomechanical response. Using Diffraction Phase Microscopy, we investigate membrane fluctuations in human RBCs parasitized by P. falciparum over the full range of intra-erythrocyte stages.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 细胞膜的动态响应可以受到人类疾病的发作和进展的影响。已知磷脂双层和附着血影蛋白细胞骨架的波动会因代谢活动引起的细胞骨架缺陷、应激和肌动蛋白-血影蛋白解离而改变。从入侵生物体（如疟疾诱导寄生虫恶性疟原虫）转运至血影蛋白细胞骨架网络中的特异性结合位点的蛋白质诱导RBC膜动力学和纳米机械响应的显著改变。利用衍射相位显微镜，我们调查膜波动在人类红细胞内阶段的整个范围内的恶性疟原虫寄生。