DYNAMICS OF RED BLOOD CELLS INFECTED BY P FALCIPARUM

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 细胞膜的动态响应可以受到人类疾病的发作和进展的影响。已知磷脂双层和附着血影蛋白细胞骨架的波动会因代谢活动引起的细胞骨架缺陷、应激和肌动蛋白-血影蛋白解离而改变。从入侵生物体（如疟疾诱导寄生虫恶性疟原虫）转运至血影蛋白细胞骨架网络中的特异性结合位点的蛋白质诱导RBC膜动力学和纳米机械响应的显著改变。利用衍射相位显微镜，我们调查膜波动在人类红细胞内阶段的整个范围内的恶性疟原虫寄生。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cell membrane dynamic responses can be influenced by the onset and progression of human diseases. Fluctuations in the phospholipid bilayer and attached spectrin cytoskeleton are known to be altered by cytoskeletal defects, stress, and actin-spectrin dissociations arising from metabolic activity. Proteins transported from invading organisms, such as the malaria-inducing parasite P. falciparum, to specific binding sites in the spectrin cytoskeletal network induce significant alterations to RBC membrane dynamics and nanomechanical response. Using Diffraction Phase Microscopy, we investigate membrane fluctuations in human RBCs parasitized by P. falciparum over the full range of intra-erythrocyte stages.