DYNAMICS OF RED BLOOD CELLS INFECTED BY P FALCIPARUM

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 细胞膜的动态反应可受人类疾病的发生和发展的影响。已知磷脂双层和附着的血影蛋白细胞骨架的波动会因细胞骨架缺陷、应激和代谢活动引起的肌动蛋白-血影蛋白解离而改变。来自入侵生物的蛋白质，如引起疟疾的恶性疟原虫，运输到血影蛋白细胞骨架网络中的特定结合位置，会引起红细胞膜动力学和纳米机械反应的显著变化。利用衍射位相显微镜，我们研究了恶性疟原虫寄生的人红细胞在红细胞内各个阶段的膜波动。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cell membrane dynamic responses can be influenced by the onset and progression of human diseases. Fluctuations in the phospholipid bilayer and attached spectrin cytoskeleton are known to be altered by cytoskeletal defects, stress, and actin-spectrin dissociations arising from metabolic activity. Proteins transported from invading organisms, such as the malaria-inducing parasite P. falciparum, to specific binding sites in the spectrin cytoskeletal network induce significant alterations to RBC membrane dynamics and nanomechanical response. Using Diffraction Phase Microscopy, we investigate membrane fluctuations in human RBCs parasitized by P. falciparum over the full range of intra-erythrocyte stages.