Neuroscience Cores For MR Studies of the Brain

特别是自从功能磁共振成像（fMRI）引入以来，大量的磁共振（MR）技术，例如神经化学光谱、灌注成像、血管解剖成像、扩散成像和功能成像等，在神经科学中扮演着不可或缺的角色。 此外，这些方法中的许多方法，甚至在诸如7特斯拉的磁场中，正在迅速地从由MR物理学家进行的技术开发领域，成为没有MR物理学专业知识的神经科学研究人员社区常规使用的不可或缺的工具。 这种MR方法在神经科学研究中的当代使用需要大量的辅助支持，包括复杂的动物手术、人类和动物模型研究中的侵入性输注、大规模数据和图像处理以及补充的非MR测量（例如，电生理学、光学成像、组织学等）。 该提案的目的是建立神经科学核心设施，以增强明尼苏达大学磁共振研究中心（CMRR）现有的最先进和独特的MR仪器资源，从而使大型神经科学研究人员能够访问和利用CMRR，A6s资源，并最大限度地发挥现代MR技术在神经科学发现中的影响。

Especially since the introduction of functional magnetic resonance imaging (fMRI), a plethora of magnetic resonance (MR) techniques, such as neurochemical spectroscopy, perfusion imaging, imaging of vascular anatomy, diffusion imaging and functional imaging etc., have come to play an indispensable role in neurosciences. Furthermore, many of these methodologies, even at ultrahigh fields such as 7 Tesla, are rapidly moving from the domain of technique development carried out by MR physicist to become an indispensable tool employed routinely by a community of neuroscience researchers without expertise in MR physics. Contemporary use of such MR methodologies in neuroscience research requires immense auxiliary support that includes complex animal surgery, invasive infusions in humans and animal model studies, large scale data and image processing, and complementary non-MR measurements (e.g. electrophysiology, optical imaging, histology etc.). The aim of this proposal is to establish Neuroscience CORE facilities that will augment the existing state-of-the art and unique MR instrumentation resources located in the Center for Magnetic Resonance Research (CMRR) at the University of Minnesota, so as to enable access and utilization of CMRR,A6s resources by a large community of neuroscience researchers, and maximize the impact of modern MR techniques in neuroscience discovery.