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Multiscale Computational Modeling of Platelet Deposition and Coagulation in Flow

流动中血小板沉积和凝固的多尺度计算模型

基本信息

批准号：
8318577
负责人：
AARON L FOGELSON
金额：
$ 31.42万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-05 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8318577
关键词：
Affect Algorithms Area Binding Biochemical Reaction Biochemistry Biology Biomedical Engineering Biophysics Blood Blood Clot Blood Platelets Blood Vessels Blood coagulation Caliber Characteristics Chemicals Chemistry Coagulation Process Collaborations Communities Complex Computer Simulation Computer software Computing Methodologies Confocal Microscopy Data Deposition Development Education Engineering Enzymes Event Fibrin Foundations Future Gel Goals Grant Illinois Inflammation Institutes Instruction Investigation Lead Life Liquid substance Medical Medical Device Modeling Modification Myocardial Infarction Neoplasm Metastasis Performance Perfusion Physiological Process Reaction Research Research Personnel Science Scientist Simulate Societies Stroke Students Surface System Technology Thrombin Thrombosis Thrombus Time Validation Work arteriole atherogenesis chemical release computerized tools cost design empowered fibrous protein improved innovation model development novel parallel computing polymerization prevent research study simulation software development systems research tool venule

项目摘要

The long term goal of this project is to develop state of the art computational models of thrombosis in order to explore how physical and chemical factors interact to determine its progression. An integral component of the developmental work will be the experimental validation of the models using well-established perfusion systems and confocal microscopy for determining the characteristics of thrombus deposition. Specifically, 3D computational models of i) platelet mural thrombosis in small diameter blood vessels (arterioles), and ii) combined platelet thrombosis and coagulation in small vessels (arterioles and venules) will be developed. The models will be designed to take full advantage of high performance parallel computing capabilities as well as innovative mathematical and computational methods and will permit exploration of the complex, dynamic, and multiscale interplay between flow, chemistry and vascular biology in thrombosis. Through a Consortium arrangement with Dr. Vincent Turitto and his thrombosis group at the Illinois Institute of Technology, experiments will be conducted to provide the necessary experimental data. Modification of the models will occur through close interaction between the computational and experimental groups, and with the assistance of an Advisory Group of thrombosis experts. The project thus brings together a unique cross-disciplinary team of mathematicians, computational scientists, biomedical engineers and life scientists in a well integrated computational and experimental effort to understand intravascular thrombosis and to develop reliable models for predicting the course of thrombotic events that can help in designing improved medical devices and therapies to prevent and treat thrombosis.

该项目的长期目标是开发最先进的血栓形成计算模型，以探索物理和化学因素如何相互作用以确定其进展。开发工作的一个组成部分将是使用完善的灌注系统对模型进行实验验证