Biobehavioral Trajectories of Social Anxiety from Early to Middle Adolescence

青春期早期到中期社交焦虑的生物行为轨迹

• 批准号: 9596413
• 负责人: Kristin A Buss
• 金额: $ 73.58万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-17 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9596413
• 关键词: Address; Adolescence; Adolescent; Adult; Age; Anxiety; Attention; Behavior; Behavioral; Behavioral inhibition; Benign; Biological; Biological Markers; Biology; Child; Child Rearing; Childhood; Classification; Clinical; Comorbidity; Development; Developmental Course; Developmental Process; Diagnosis; Diagnostic; Dimensions; Electroencephalography; Endocrine; Etiology; Evoked Potentials; Expressed Sequence Tags; Foundations; Fright; Functional disorder; Growth; Heterogeneity; Hydrocortisone; Impairment; Individual; Individual Differences; Link; Literature; Longitudinal Studies; Measures; Mental Depression; Methods; Modeling; National Institute of Mental Health; Negative Valence; Neurobiology; Neurosecretory Systems; Outcome; Pathway interactions; Pattern; Physiological; Predisposition; Prevalence; Process; Psychopathology; Psychophysiology; Puberty; Reporting; Research Domain Criteria; Risk; Risk Factors; Sampling; School-Age Population; Sex Characteristics; Sexual Maturation; Shapes; Social Anxiety Disorder; Social Development; Social Functioning; Symptoms; System; Temperament; Testing; Toddler; Translating; Treatment Effectiveness; Variant; Work; Youth; anxiety symptoms; anxious; anxious behavior; associated symptom; attentional bias; base; biobehavior; boys; clinical anxiety; cognitive system; contextual factors; disorder risk; early adolescence; girls; high risk; high school; junior high school; longitudinal design; neural circuit; peer; prospective; recruit; relating to nervous system; social; social anxiety; social situation; stem; symptomatology

Social Anxiety Disorder (SAD) is among the most common forms of pediatric psychopathology. These symptoms are associated with significant impairment encompassing familial, social and academic domains, and they are often comorbid with other internalizing symptoms (e.g., depression) especially in adolescence and into adulthood. Efforts to address the burden of SAD suffer from the limited understanding of its underlying pathophysiology. SAD symptoms peak in adolescence making this developmental transition an important period to study. However, considerable heterogeneity in symptomatology, risk factors, and underlying biology exists across anxious adolescents, which has implications for (1) understanding the developmental etiology of who is at highest risk, (2) identifying individual profiles of symptom course, (3) matching treatments to symptom patterns and (4) determining for whom these treatments are most effective. A substantial clinical literature exists focused on anxiety problems in children and adolescents examining clinical features with little focus on developmental processes and biological mechanisms. In contrast, the developmental literature is dominated by a temperament approach whereby extreme fearful temperament is our strongest individual differences predictor of anxiety. Exclusive focus on either model creates a barrier to progress in the field. Specifically, (1) identification of anxiety problems is typically diagnostic, with classification based solely on reported anxious behavior (rather than convergent information from different types of measures to predict a dimensional outcome); (2) we have a limited understanding of the underlying processes linking fearful temperament and anxiety across development; (3) most anxiety in children is benign, yet we lack methods to separate the true cases from false positives; and (4) although early temperament variation is ideal for identifying risk and potential mechanisms, we know little about how variation in temperament influences symptom course and effectiveness of treatments. The current study will employ a longitudinal design including continuation of a sub- sample followed since 24-months and characterized for fearful temperament. We add to this addition youth recruited for a range of SAD symptoms. Together this sampling will capture a wide range of anxiety symptom presentation (i.e., low risk, temperamental risk, and clinical anxiety). We will follow adolescents (N = 240) annually across the transitions to middle- and high-school – ages 13, 14, 15, & 16 years. We will implement a rich assessment of anxiety symptoms, temperament, attention bias, endocrine (cortisol), physiological (RSA) and neurobiological (N1, P2, N2 evoked potentials of attention) processes. This multi-method approach aligns with the NIMH objective 2.2 to identify biomarkers and behavioral indicators of illness trajectories and explicitly tests components of the Research Domain Criteria (RDoC). Specifically, we will examine the development of the Negative Valence System of Potential Threat (“anxiety”), and the Cognitive System of Attention across multiple units of analysis including behavioral, physiological, and neural circuits.

社交焦虑障碍（SAD）是儿科精神病理学中最常见的形式之一。这些 症状与包括家庭、社会和学术领域的重大损害有关， 并且它们经常与其它内在化症状共病（例如，抑郁症），尤其是在青春期 直到成年由于人们对撒哈拉以南非洲发展中国家的基本情况了解有限， 病理生理学SAD症状在青春期达到高峰，使这种发展转变成为一个重要的 学习的时间。然而，在肿瘤学、危险因素和基础生物学方面存在相当大的异质性， 存在于焦虑的青少年中，这对（1）理解青少年的发展病因学有影响。 谁处于最高风险，（2）识别症状过程的个体特征，（3）将治疗与症状匹配 （4）确定这些治疗对谁最有效。大量临床文献 存在集中于儿童和青少年的焦虑问题，检查临床特征， 发育过程和生物学机制。与此相反，发展文学主要是由 一种气质方法，极端恐惧的气质是我们最大的个体差异， 焦虑的预测器对任何一种模式的专门关注都会对该领域的进展造成障碍。具体而言，（1） 焦虑问题的识别通常是诊断性的，分类仅仅基于报告的焦虑 行为（而不是来自不同类型的测量的收敛信息，以预测维度 结果）;（2）我们对连接恐惧气质的潜在过程的理解有限， 儿童的焦虑大多是良性的，但我们缺乏方法来区分真正的焦虑。 假阳性病例;（4）虽然早期气质变化是识别风险的理想方法， 潜在的机制，我们对气质的变化如何影响症状过程知之甚少， 治疗的有效性。目前的研究将采用纵向设计，包括一个亚组的延续， 样本从24个月开始跟踪，并以可怕的气质为特征。我们再加上青春 因一系列悲伤症状而被招募这些样本将共同捕捉到广泛的焦虑症状 呈现（即，低风险，气质风险和临床焦虑）。我们将随访青少年（N = 240） 每年在过渡到初中和高中-年龄13，14，15，和16岁。我们将合理安排 丰富的评估焦虑症状，气质，注意力偏差，内分泌（皮质醇），生理（RSA） 和神经生物学（注意的N1、P2、N2诱发电位）过程。这种多方法方法使 与NIMH目标2.2，以确定疾病轨迹的生物标志物和行为指标， 测试研究领域标准（RDoC）的组成部分。具体而言，我们将研究 潜在威胁的负价系统（“焦虑”）和跨文化的注意力认知系统 多个分析单元，包括行为、生理和神经回路。