Context-dependent processing in sensorimotor cortex

感觉运动皮层的上下文相关处理

基本信息

项目摘要

ABSTRACT Humans interact with their environment in countless ways and can switch seamlessly between activities. Even for seemingly simple tasks, a variety of sensory inputs are integrated to create a motor plan to complete a task. Take the example of picking up a glass. Visual, tactile, and proprioceptive inputs provide cues about the position and weight of the object as well as limb state. Additional sensory and contextual inputs can also influence the movement. For example, a person might pick up a glass differently if she is intending to take a drink, versus clear off a table. She may grasp a glass more carefully if it is very full to avoid spilling it requiring a change in the motor control scheme. Our central hypothesis is that sensory and motor aspects of task context systematically modulate the neural representation of action as well as conscious sensory perception. We will manipulate aspects of task context to study sensorimotor processing during grasping and object exploration tasks. Intracortical recordings from human motor cortex will be used to study the neural representation of action for various manipulations of task goals, motor control schemes, and expected and actual sensory inputs. Sensory input will be provided using both intact perception (vision) and intracortical microstimulation of somatosensory cortex to impart cutaneous sensations. Tasks involving object grasping and exploration will be performed with a brain-computer interface (BCI) and robotic arm and hand, which allows us to precisely control the mapping between neural activity and movement as well as the somatosensory inputs. Previous work supports the idea that neural activity generated during attempted movements in people with spinal cord injury exhibits the same relationship to movement variables as an able-bodied subject. Similarly, stimulation of somatosensory cortex in a person with chronic tetraplegia generates localized sensations that follow the expected spatial organization. Population-level analysis will be applied to the neuronal recordings to reveal patterns of neural activity generated by each facet of context to gain a better understanding of how goals, motor control schemes, and expected and actual sensory inputs influence the neural representation of action. We will study how vision and tactile sensation are integrated to drive conscious perception during object exploration. Conscious perception will be documented via verbal report as well as psychophysical experiments. This project will address basic- science questions about the influence of context on sensorimotor processing. The findings of this study could broadly impact neurorehabilitation approaches, while also improving the generalizability and performance of BCIs for restoring upper limb function.
摘要

项目成果

期刊论文数量(0)
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Jennifer L. Collinger其他文献

Use of Cortical Surface Stimulation towards Reliable Sensation in Human
  • DOI:
    10.1016/j.apmr.2015.10.071
  • 发表时间:
    2015-12-01
  • 期刊:
  • 影响因子:
  • 作者:
    Shivayogi V. Hiremath;Elizabeth C. Tyler-Kabara;Jesse Wheeler;Daniel W. Moran;Robert A. Gaunt;Jennifer L. Collinger;Stephen Thomas Foldes;Douglas John Weber;Weidong Chen;Michael Boninger;Wei Wang
  • 通讯作者:
    Wei Wang
Evoking stable and precise tactile sensations via multi-electrode intracortical microstimulation of the somatosensory cortex
通过体感皮层的多电极皮层内微刺激唤起稳定而精确的触觉感受
  • DOI:
    10.1038/s41551-024-01299-z
  • 发表时间:
    2024-12-06
  • 期刊:
  • 影响因子:
    26.600
  • 作者:
    Charles M. Greenspon;Giacomo Valle;Natalya D. Shelchkova;Taylor G. Hobbs;Ceci Verbaarschot;Thierri Callier;Ev I. Berger-Wolf;Elizaveta V. Okorokova;Brianna C. Hutchison;Efe Dogruoz;Anton R. Sobinov;Patrick M. Jordan;Jeffrey M. Weiss;Emily E. Fitzgerald;Dillan Prasad;Ashley Van Driesche;Qinpu He;Fang Liu;Robert F. Kirsch;Jonathan P. Miller;Ray C. Lee;David Satzer;Jorge Gonzalez-Martinez;Peter C. Warnke;Abidemi B. Ajiboye;Emily L. Graczyk;Michael L. Boninger;Jennifer L. Collinger;John E. Downey;Lee E. Miller;Nicholas G. Hatsopoulos;Robert A. Gaunt;Sliman J. Bensmaia
  • 通讯作者:
    Sliman J. Bensmaia

Jennifer L. Collinger的其他文献

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{{ truncateString('Jennifer L. Collinger', 18)}}的其他基金

Quantifying neural variability and learning during real world brain-computer interface use
量化现实世界脑机接口使用过程中的神经变异和学习
  • 批准号:
    10838152
  • 财政年份:
    2023
  • 资助金额:
    $ 57.08万
  • 项目类别:
Development of an EMG-controlled BCI for biomimetic control of hand movement in humans
开发 EMG 控制的 BCI,用于仿生控制人类手部运动
  • 批准号:
    10651404
  • 财政年份:
    2023
  • 资助金额:
    $ 57.08万
  • 项目类别:
Quantifying neural variability and learning during real world brain-computer interface use
量化现实世界脑机接口使用过程中的神经变异和学习
  • 批准号:
    10548865
  • 财政年份:
    2022
  • 资助金额:
    $ 57.08万
  • 项目类别:
The interplay between kinematic and force representations in motor and somatosensory cortices during reaching, grasping, and object transport
伸手、抓握和物体运输过程中运动和体感皮层运动学和力表征之间的相互作用
  • 批准号:
    10546486
  • 财政年份:
    2022
  • 资助金额:
    $ 57.08万
  • 项目类别:
Quantifying neural variability and learning during real world brain-computer interface use
量化现实世界脑机接口使用过程中的神经变异和学习
  • 批准号:
    10363903
  • 财政年份:
    2022
  • 资助金额:
    $ 57.08万
  • 项目类别:
Influence of Task Complexity and Sensory Feedback on Cortical Control of Grasp Force
任务复杂性和感觉反馈对皮质控制握力的影响
  • 批准号:
    10705074
  • 财政年份:
    2021
  • 资助金额:
    $ 57.08万
  • 项目类别:
Influence of task complexity and sensory feedback on cortical control of grasp force
任务复杂性和感觉反馈对皮质控制抓握力的影响
  • 批准号:
    10289762
  • 财政年份:
    2021
  • 资助金额:
    $ 57.08万
  • 项目类别:
Influence of task complexity and sensory feedback on cortical control of grasp force
任务复杂性和感觉反馈对皮质控制抓握力的影响
  • 批准号:
    10480085
  • 财政年份:
    2021
  • 资助金额:
    $ 57.08万
  • 项目类别:
Eighth International Brain Computer Interface Meeting
第八届国际脑机接口会议
  • 批准号:
    9913702
  • 财政年份:
    2020
  • 资助金额:
    $ 57.08万
  • 项目类别:
Investigation of Cortical Changes Following Spinal Cord Injury
脊髓损伤后皮质变化的调查
  • 批准号:
    8200932
  • 财政年份:
    2012
  • 资助金额:
    $ 57.08万
  • 项目类别:

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