Context-dependent processing in sensorimotor cortex
感觉运动皮层的上下文相关处理
基本信息
- 批准号:9791028
- 负责人:
- 金额:$ 57.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-30 至 2021-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAreaBasic ScienceBehaviorBehavior ControlChronicClinicalCollaborationsColorComplexConsciousCuesCutaneousDevelopmentDimensionsEnvironmentEsthesiaExhibitsFreedomFurnitureGlassGoalsHandHumanInstructionInvestigationLeadLearningLiftingLimb structureMacaca mulattaMonkeysMotivationMotorMotor CortexMovementNeedlesNeuronsNeurorehabilitationParalysedPatternPerceptionPerformancePersonsPopulationPositioning AttributePropertyPsychophysicsQuadriplegiaReportingResearchRoboticsSchemeSensorySeriesSomatosensory CortexSpinal cord injuryStructureTactileTechniquesTechnologyTestingTextureTimeTouch sensationUpper ExtremityUser-Computer InterfaceVisionVisualVolitionWeightWorkarmbasebrain computer interfaceexperienceexperimental studygraspimprovedkinematicsmicrostimulationmotor controlneural patterningnew technologynovel therapeuticsrelating to nervous systemsensory feedbacksensory inputsensory integrationsomatosensory
项目摘要
ABSTRACT
Humans interact with their environment in countless ways and can switch seamlessly between activities. Even
for seemingly simple tasks, a variety of sensory inputs are integrated to create a motor plan to complete a task.
Take the example of picking up a glass. Visual, tactile, and proprioceptive inputs provide cues about the
position and weight of the object as well as limb state. Additional sensory and contextual inputs can also
influence the movement. For example, a person might pick up a glass differently if she is intending to take a
drink, versus clear off a table. She may grasp a glass more carefully if it is very full to avoid spilling it requiring
a change in the motor control scheme. Our central hypothesis is that sensory and motor aspects of task
context systematically modulate the neural representation of action as well as conscious sensory perception.
We will manipulate aspects of task context to study sensorimotor processing during grasping and object
exploration tasks. Intracortical recordings from human motor cortex will be used to study the neural
representation of action for various manipulations of task goals, motor control schemes, and expected and
actual sensory inputs. Sensory input will be provided using both intact perception (vision) and intracortical
microstimulation of somatosensory cortex to impart cutaneous sensations. Tasks involving object grasping and
exploration will be performed with a brain-computer interface (BCI) and robotic arm and hand, which allows us
to precisely control the mapping between neural activity and movement as well as the somatosensory inputs.
Previous work supports the idea that neural activity generated during attempted movements in people with
spinal cord injury exhibits the same relationship to movement variables as an able-bodied subject. Similarly,
stimulation of somatosensory cortex in a person with chronic tetraplegia generates localized sensations that
follow the expected spatial organization.
Population-level analysis will be applied to the neuronal recordings to reveal patterns of neural activity
generated by each facet of context to gain a better understanding of how goals, motor control schemes, and
expected and actual sensory inputs influence the neural representation of action. We will study how vision and
tactile sensation are integrated to drive conscious perception during object exploration. Conscious perception
will be documented via verbal report as well as psychophysical experiments. This project will address basic-
science questions about the influence of context on sensorimotor processing. The findings of this study could
broadly impact neurorehabilitation approaches, while also improving the generalizability and performance of
BCIs for restoring upper limb function.
摘要
人类以无数方式与环境互动,并可以在活动之间无缝切换。甚至
对于看似简单的任务,各种感觉输入被整合以创建完成任务的运动计划。
举一个拿起杯子的例子。视觉、触觉和本体感受输入提供了关于
物体的位置和重量以及肢体状态。附加的感觉和上下文输入也可以
影响运动。例如,如果一个人打算拿一个杯子,
喝酒,而不是收拾桌子。她可能会更小心地抓住一个玻璃,如果它是非常充分的,以避免溢出它需要
电机控制方案的变化。我们的中心假设是,任务的感觉和运动方面
背景系统地调节行为的神经表征以及有意识的感官知觉。
我们将操纵任务背景的各个方面来研究抓握和物体过程中的感觉运动加工
探索任务。人类运动皮质的皮质内记录将用于研究神经
任务目标、运动控制方案和预期的各种操作的动作表示,
真实的感官输入将使用完整感知(视觉)和皮质内
微刺激躯体感觉皮层以传递皮肤感觉。涉及物体抓取和
探索将通过脑机接口(BCI)和机器人手臂和手进行,这使我们能够
精确控制神经活动和运动以及体感输入之间的映射。
以前的工作支持这样一种观点,即在患有糖尿病的人尝试运动时产生的神经活动
脊髓损伤表现出与健全受试者相同的运动变量关系。同样地,
刺激患有慢性四肢瘫痪的人的躯体感觉皮层产生局部感觉,
按照预期的空间布局。
群体水平的分析将应用于神经元记录,以揭示神经活动的模式
由上下文的每个方面产生,以更好地理解目标,运动控制方案,
预期的和实际的感觉输入影响动作的神经表征。我们将研究视觉和
触觉被整合以在物体探索期间驱动有意识感知。意识知觉
将通过口头报告和心理物理实验记录下来。该项目将解决基本问题-
科学界质疑语境对感觉运动处理的影响。这项研究的结果可以
广泛影响神经康复方法,同时也提高了
用于恢复上肢功能的BCI。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jennifer L. Collinger其他文献
Use of Cortical Surface Stimulation towards Reliable Sensation in Human
- DOI:
10.1016/j.apmr.2015.10.071 - 发表时间:
2015-12-01 - 期刊:
- 影响因子:
- 作者:
Shivayogi V. Hiremath;Elizabeth C. Tyler-Kabara;Jesse Wheeler;Daniel W. Moran;Robert A. Gaunt;Jennifer L. Collinger;Stephen Thomas Foldes;Douglas John Weber;Weidong Chen;Michael Boninger;Wei Wang - 通讯作者:
Wei Wang
Evoking stable and precise tactile sensations via multi-electrode intracortical microstimulation of the somatosensory cortex
通过体感皮层的多电极皮层内微刺激唤起稳定而精确的触觉感受
- DOI:
10.1038/s41551-024-01299-z - 发表时间:
2024-12-06 - 期刊:
- 影响因子:26.600
- 作者:
Charles M. Greenspon;Giacomo Valle;Natalya D. Shelchkova;Taylor G. Hobbs;Ceci Verbaarschot;Thierri Callier;Ev I. Berger-Wolf;Elizaveta V. Okorokova;Brianna C. Hutchison;Efe Dogruoz;Anton R. Sobinov;Patrick M. Jordan;Jeffrey M. Weiss;Emily E. Fitzgerald;Dillan Prasad;Ashley Van Driesche;Qinpu He;Fang Liu;Robert F. Kirsch;Jonathan P. Miller;Ray C. Lee;David Satzer;Jorge Gonzalez-Martinez;Peter C. Warnke;Abidemi B. Ajiboye;Emily L. Graczyk;Michael L. Boninger;Jennifer L. Collinger;John E. Downey;Lee E. Miller;Nicholas G. Hatsopoulos;Robert A. Gaunt;Sliman J. Bensmaia - 通讯作者:
Sliman J. Bensmaia
Jennifer L. Collinger的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jennifer L. Collinger', 18)}}的其他基金
Quantifying neural variability and learning during real world brain-computer interface use
量化现实世界脑机接口使用过程中的神经变异和学习
- 批准号:
10838152 - 财政年份:2023
- 资助金额:
$ 57.08万 - 项目类别:
Development of an EMG-controlled BCI for biomimetic control of hand movement in humans
开发 EMG 控制的 BCI,用于仿生控制人类手部运动
- 批准号:
10651404 - 财政年份:2023
- 资助金额:
$ 57.08万 - 项目类别:
Quantifying neural variability and learning during real world brain-computer interface use
量化现实世界脑机接口使用过程中的神经变异和学习
- 批准号:
10548865 - 财政年份:2022
- 资助金额:
$ 57.08万 - 项目类别:
The interplay between kinematic and force representations in motor and somatosensory cortices during reaching, grasping, and object transport
伸手、抓握和物体运输过程中运动和体感皮层运动学和力表征之间的相互作用
- 批准号:
10546486 - 财政年份:2022
- 资助金额:
$ 57.08万 - 项目类别:
Quantifying neural variability and learning during real world brain-computer interface use
量化现实世界脑机接口使用过程中的神经变异和学习
- 批准号:
10363903 - 财政年份:2022
- 资助金额:
$ 57.08万 - 项目类别:
Influence of Task Complexity and Sensory Feedback on Cortical Control of Grasp Force
任务复杂性和感觉反馈对皮质控制握力的影响
- 批准号:
10705074 - 财政年份:2021
- 资助金额:
$ 57.08万 - 项目类别:
Influence of task complexity and sensory feedback on cortical control of grasp force
任务复杂性和感觉反馈对皮质控制抓握力的影响
- 批准号:
10289762 - 财政年份:2021
- 资助金额:
$ 57.08万 - 项目类别:
Influence of task complexity and sensory feedback on cortical control of grasp force
任务复杂性和感觉反馈对皮质控制抓握力的影响
- 批准号:
10480085 - 财政年份:2021
- 资助金额:
$ 57.08万 - 项目类别:
Eighth International Brain Computer Interface Meeting
第八届国际脑机接口会议
- 批准号:
9913702 - 财政年份:2020
- 资助金额:
$ 57.08万 - 项目类别:
Investigation of Cortical Changes Following Spinal Cord Injury
脊髓损伤后皮质变化的调查
- 批准号:
8200932 - 财政年份:2012
- 资助金额:
$ 57.08万 - 项目类别:
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 57.08万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 57.08万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 57.08万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 57.08万 - 项目类别:
Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 57.08万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 57.08万 - 项目类别:
Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 57.08万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 57.08万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 57.08万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 57.08万 - 项目类别:
Studentship














{{item.name}}会员




